Method for producing blocked isocyanate compound
A technology for blocking isocyanates and manufacturing methods, which is applied in the preparation of organic compounds, chemical instruments and methods, and the preparation of carbamic acid derivatives. It can solve problems such as environmental burdens and cost increases, and achieve the effect of simplifying manufacturing equipment and reducing burdens
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Embodiment 1
[0150] In a 2L separate flask with a stirrer, a condenser and a thermometer, 150.0 g of 2-(O-[1'-methylpropylideneamino]oxycarbonylamino)ethyl acrylate, 2,6-di-tert- Butyl-4-methylphenol (BHT) was 0.11 g, and the temperature was adjusted to 10°C. Next, 141.1 g (1.00 mol) of 2-(acryloyloxy) ethyl isocyanate (manufactured by Showa Denko Co., Ltd.; product name Karenz AOI (registered trademark)) and 87.1 g (1.00 mol) of butanone oxime (MEKO) were separated. It was added dropwise over 5 hours using a dropping funnel. After completion of the dropwise addition, the mixture was stirred for 1 hour with the internal temperature adjusted to 20°C to obtain 2-(O-[1'-methylpropylideneamino]oxycarbonylamino)ethyl acrylate.
[0151] Table 1 shows the results of analyzing the composition of the product by HPLC and GC.
[0152] In addition, only the amount of BHT was quantified by GC, and other components were quantified using HPLC. GC analysis conditions and HPLC analysis conditions are sh...
reference example 2
[0174] Add 150.0 g of 2-(O-[1'-methylpropylideneamino]oxycarbonylamino)ethyl acrylate, 2,6-di-tert- Butyl-4-methylphenol (BHT) was 0.11 g, and the temperature was adjusted to 10°C. Next, 141.1 g (1.00 mol) of 2-(acryloyloxy) ethyl isocyanate (manufactured by Showa Denko Co., Ltd.; product name Karenz AOI (registered trademark)) and 87.1 g (1.00 mol) of butanone oxime (MEKO) were separated. Dropwise additions were performed simultaneously using a dropping funnel. At this time, the dripping was carried out at a constant dripping speed when the 2-(acryloyloxy)ethyl isocyanate could be dripped in 5 hours and the butanone oxime could be dripped in 4 hours. After the dripping of 2-(acryloyloxy)ethyl isocyanate is completed, stir for 1 hour while adjusting the internal temperature to 20°C to obtain 2-(O-[1'-methylpropylidene acrylic acid Amino]oxycarbonylamino)ethyl ester.
[0175] Table 1 shows the results of analyzing the composition of the product by HPLC and GC.
[0176] In a...
reference example 3
[0178] Add 14.3 g of 2-(O-[1'-methylpropylidene amino]oxycarbonyl amino) ethyl acrylate and 43.56 g (0.50 mol) of butanone oxime (MEKO) in a 200 mL 3-necked flask, and the temperature Adjust to 10°C. 71.0 g (0.50 ml) of 2-(acryloyloxy)ethyl isocyanate was added dropwise over 5 hours using a 50 mL dropping funnel. After completion of the dropping, the mixture was stirred for 1 hour with the internal temperature adjusted to 20°C to obtain 2-(O-[1'-methylpropylideneamino]oxycarbonylamino)ethyl acrylate.
[0179] Table 1 shows the results of analyzing the composition of the product by HPLC and GC.
[0180] In addition, only the amount of BHT was quantified by GC analysis, and other components were quantified using HPLC. GC analysis conditions and HPLC analysis conditions are the same as in Example 1.
[0181] Table 1
[0182]
[0183] According to the production methods of Example 1 and Reference Examples 2 and 3, since no solvent is used, the product does not contain a sol...
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