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Foaming formula for nasal care

A formula and nasal cavity technology, applied in the field of care agents, can solve problems such as delayed disintegration time, poor solubility, and decreased stability of dosage forms, and achieve the effect of solving compatibility problems

Inactive Publication Date: 2018-11-06
JIANGSU APON MEDICAL TECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Although effervescent technology has been widely studied and applied in immediate-release preparations and sustained-release preparations, due to the special formulation of effervescent preparations and the acid-base content, if the formulation is improper, long-term storage will easily lead to a decrease in the stability of the dosage form. Defects such as poor tablet shape, delayed disintegration time, and poor solubility

Method used

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  • Foaming formula for nasal care

Examples

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Effect test

Embodiment 1

[0028] An effervescent formula for nasal cavity care, the specific weight percentage of each component is: filling care agent, including 22% sodium chloride, 3% sodium bicarbonate and 10% mannitol; disintegrating agent, including 26% citric acid and 34% sodium bicarbonate; binder, including 3% polyvinylpyrrolidone; lubricant, including 2% PEG6000. The disintegration time of the prepared tablet is 2 minutes, the moisturizing time is short, the nasal cavity comfort is poor, and there is very little precipitation.

Embodiment 2

[0030] An effervescent formula for nasal cavity care, the weight percentage of each component is specifically: filling care agent, including 34.5% sodium chloride, 1% sodium bicarbonate, 2.5% sodium pyruvate, 0.5% water-soluble Chitosan and 20% mannitol; disintegrants, including 15% citric acid and 21% sodium bicarbonate; binders, including 2% polyvinylpyrrolidone; lubricants, including 2% PEG6000 ; Cooling agents, including peppermint 0.5%. The disintegration time of the prepared powder is 2.5 minutes, the moisturizing time is long, the nasal cavity is comfortable, and there is very little precipitation.

Embodiment 3

[0032] An effervescent formula for nasal cavity care, the specific weight percentage of each component is: filling care agent, including 15.5% sodium chloride, 4.45% sodium bicarbonate, 14% xylitol, 0.05% transparent Sodium hyaluronate, 0.5% water-soluble chitosan, and 20% mannitol; disintegrant, including 17.3% citric acid and 22.7% sodium bicarbonate; binder, including 3% polyvinylpyrrolidone ; lubricants, including 2% PEG6000; cooling agents, including 0.5% mint. The disintegration time of the prepared tablet is 4.5 minutes, the moisturizing time is long, the nasal cavity is comfortable, and there is very little precipitation.

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Abstract

The invention discloses a foaming formula for nasal care. The foaming formula is prepared from, by weight, 30-60% of a nursing filler, 30-60% of a disintegrating agent, 0.5-10% of a binding agent, 0.5-5% of a PH regulator, 1-5% of a lubricating agent and 0.5-1% of a freshener. The foaming formula is mainly applied to nasal care of nasal wash, nasal mucosal care, nasal irrigation and the like, intranasal environment can be improved remarkably, and nasal inflammation is reduced.

Description

technical field [0001] The invention relates to a care agent, in particular to an effervescent formula for nasal cavity care. Background technique [0002] The nasal cavity is the portal of the respiratory tract. Due to the superficial anatomical part and the certain absorption function of the nasal mucosa, nasal irrigation is a common method for treating nasal cavity and sinus diseases. Due to its good curative effect and tolerance, it has been favored by doctors and patients. Welcome. Nasal irrigation refers to a treatment method that uses a suitable device to deliver irrigation liquid to the nasal cavity, and through the contact of the medicinal liquid with the target tissue of the nasal cavity, it can achieve the purpose of cleaning the nasal cavity and drug treatment. The method is easy to operate and is an important means to effectively treat nasal cavity diseases such as sinusitis, and has been widely used in medical equipment and other industries. [0003] Reasonab...

Claims

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Application Information

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IPC IPC(8): A61K33/14A61K36/534A61K9/20A61K9/14A61K47/02A61P11/02A61K31/047A61K33/00A61K31/19A61K31/722A61K31/728A61K31/045
CPCA61K9/0007A61K9/0043A61K9/143A61K9/2009A61K31/045A61K31/047A61K31/19A61K31/722A61K31/728A61K33/00A61K33/14A61K36/534A61P11/02A61K2300/00
Inventor 张智慧王晶翟小晶韩小健汤宁伟
Owner JIANGSU APON MEDICAL TECHNOLOGY CO LTD
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