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Preparation method of injectable self-healing hydrogel and product of hydrogel

A hydrogel and self-healing technology, applied in the field of preparation of self-healing hydrogels, can solve the problem that the mechanical strength and self-healing ability of self-healing hydrogels cannot meet the application requirements, and cannot be replaced by biological tissues. Repair, complex preparation process and other problems, to achieve the effect of superior mechanical properties, good biocompatibility, and simple synthesis process

Inactive Publication Date: 2018-11-06
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Ordinary hydrogels are soft and brittle, and their mechanical strength is relatively poor, which makes them unable to be used for the replacement and repair of biological tissues under high loads, which largely limits their applications.
[0004] The self-healing performance of traditional self-healing hydrogels is mainly through the dynamic characteristics of physical bonds or chemically reversible bonds to achieve self-healing. The mechanical strength and self-healing ability of this self-healing hydrogel cannot meet the needs of applications. limit its application
Moreover, traditional self-healing hydrogels are complicated to prepare and expensive, which further limits their application.

Method used

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  • Preparation method of injectable self-healing hydrogel and product of hydrogel
  • Preparation method of injectable self-healing hydrogel and product of hydrogel

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preparation example Construction

[0061] The preparation method of the injectable self-healing hydrogel of the present invention comprises the following steps:

[0062] A, at room temperature, the polyglutamic acid of 4~7 parts by weight and the tyramine hydrochloride of 2-5 parts by weight are dissolved in the distilled water of 45~55 parts by weight and make the two dissolve completely, obtain polyglutamic acid and hydrochloric acid tyramine precursor solution;

[0063] B, add 2~7 parts by weight of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride in the obtained precursor solution of step A and mix the two evenly;

[0064] C. Add 1.5-5 parts by weight of N-hydroxysuccinimide to the solution obtained in step B, stir rapidly until the mixture is uniform, and finally obtain an injectable self-healing hydrogel.

[0065] further,

[0066] The preparation method of the injectable self-healing hydrogel, is characterized in that, comprises the following steps:

[0067] A, at room temperature, the poly...

Embodiment 1

[0108] A. 4 parts of polyglutamic acid and 2 parts of tyramine hydrochloride are dissolved in 45 parts of distilled water at room temperature, and stirred until it is completely dissolved to obtain a precursor solution of polyglutamic acid and tyramine hydrochloride;

[0109] B, add 2 parts of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride in the obtained precursor solution of step A, stir rapidly to make it evenly mixed;

[0110] C. Add 1.5 parts of N-hydroxysuccinimide to the solution obtained in step B, stir rapidly until the mixture is uniform, and finally obtain an injectable self-healing hydrogel.

Embodiment 2

[0112] A. 5 parts of polyglutamic acid and 3 parts of tyramine hydrochloride are dissolved in 45 parts of distilled water at room temperature, and stirred until it is completely dissolved to obtain the precursor solution of polyglutamic acid and tyramine hydrochloride;

[0113] B, add 3 parts of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride in the obtained precursor solution of step A, stir rapidly to make it evenly mixed;

[0114] C. Add 2.5 parts of N-hydroxysuccinimide to the solution obtained in step B, stir rapidly until the mixture is uniform, and finally obtain an injectable self-healing hydrogel.

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Abstract

The invention discloses a preparation method of injectable self-healing hydrogel. The method is characterized by comprising the following steps: A, dissolving 4-7 parts by weight of polyglutamic acidand 2-5 parts by weight of tyramine hydrochloride in 44-55 parts by weight of distilled water at room temperature, enabling the polyglutamic acid and the tyramine hydrochloride to be completely dissolved to obtain a precursor solution of the polyglutamic acid and the tyramine hydrochloride; B, adding 2-7 parts by weight of 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride in the precursor solution obtained in step A, and mixing the 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and the precursor solution uniformly; and C, adding 1.5-5 parts by weight of N-hydroxysuccinimide in a solution obtained in step B, stirring rapidly to mix uniformly to obtain the injectable self-healing hydrogel finally. The invention further discloses an injectable self-healing hydrogel product prepared by the preparation method.

Description

technical field [0001] The invention relates to the technical field of hydrogel materials, in particular, to a preparation method of an injectable self-healing hydrogel and a product thereof. Background technique [0002] As a cross-linked polymer material containing a large amount of water in the matrix, polymer hydrogels have been widely used in many fields such as food, cosmetics and biomedicine. Synthetic materials that repair themselves from damage have been rapidly developed due to their many potential applications. As a new type of biomaterial, self-healing hydrogels have been regarded as a new material to replace traditional injectable hydrogels. Compared with traditional injectable hydrogels, self-healing hydrogels can encapsulate drugs uniformly, yielding better reproducible experimental results and higher therapeutic activity of drugs and cells under physiological conditions in vitro. After injection in vivo, the broken hydrogel fragments can regenerate a comple...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/18A61L27/52A61L27/58A61K9/06A61K47/34
CPCA61K9/0024A61K9/06A61K47/34A61L27/18A61L27/52A61L27/58A61L2400/06C08L77/04
Inventor 汪建新王莹莹徐啟真陈太军左莹莹丁瑞魏冉
Owner SOUTHWEST JIAOTONG UNIV
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