A combination drug therapy composition used for treating amyotrophic lateral sclerosis and a preparation method and use thereof

A technology of lateral sclerosis and drug combination, which is applied in the direction of drug combination, drug formulation, drug delivery, etc., can solve the problems of unsatisfactory effects, and achieve the effect of no toxic side effects and simple preparation method

Active Publication Date: 2018-11-09
SICHUAN JIUZHANG BIO TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It has been reported that chlorogenic acid has a certain therapeutic effect on amyotrophic lateral sclerosis (ALS), but the effect is still unsatisfactory

Method used

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  • A combination drug therapy composition used for treating amyotrophic lateral sclerosis and a preparation method and use thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment 1: a kind of combination medicine composition for the treatment of amyotrophic lateral sclerosis

[0033] It consists of a unit preparation containing 300 mg of chlorogenic acid, a unit preparation containing 500 mg of vitamin E, a unit preparation containing 600 mg of coenzyme Q10, and a unit preparation containing 2500 mg of creatine phosphate sodium. The unit preparations in the combined drug composition are administered simultaneously or separately medicine.

Embodiment 2

[0034] Embodiment 2: A kind of tablet for treating amyotrophic lateral sclerosis

[0035] Chlorogenic acid 300g, vitamin E 500g, vitamin C 600g, coenzyme Q10 600g, creatine phosphate sodium 2500g, prepared according to the following method:

[0036] (1) Material preparation: take each bulk drug according to the formula;

[0037] (2) Mixing: Mix chlorogenic acid, vitamin E, vitamin C, coenzyme Q10 and creatine sodium phosphate evenly, add microcrystalline cellulose, hydroxypropyl methylcellulose, sodium carboxymethyl starch, and then wet granulate, After adding magnesium stearate, tableting was made into 10,000 tablets, each containing 30 mg of chlorogenic acid, to obtain the tablet for treating amyotrophic lateral sclerosis of the present invention.

Embodiment

[0038] Embodiment: 3, a kind of capsule for the treatment of amyotrophic lateral sclerosis

[0039] Chlorogenic acid 180g, vitamin E 300g, vitamin C 300g, coenzyme Q10 300g, sodium creatine phosphate 1000g, prepared according to the following method:

[0040] (1) Material preparation: take each bulk drug according to the formula;

[0041] Mixing: Mix chlorogenic acid, vitamin E, vitamin C, coenzyme Q10 and creatine sodium phosphate evenly, then add microcrystalline cellulose, hydroxypropyl methylcellulose, sodium carboxymethyl starch, then wet granulate, add stearin Fill it with magnesium acid, and make 6000 capsules in gelatin capsule shells, each containing 30 mg of chlorogenic acid, to obtain the capsule for treating amyotrophic lateral sclerosis of the present invention.

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PUM

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Abstract

The invention relates to a combination drug therapy composition used for treating amyotrophic lateral sclerosis and a preparation method and use thereof. The composition includes chlorogenic acid, vitamin E, vitamin C, coenzyme Q10, creatine phosphate sodium and a pharmaceutically acceptable carrier, wherein the chlorogenic acid, the vitamin E, the vitamin C, the coenzyme Q10, and the creatine phosphate sodium are unit preparations having same or different specifications and are administrated separately or together. After combination of the chlorogenic acid, the vitamin E, the vitamin C, the coenzyme Q10, and the creatine phosphate sodium, unexpected synergistic treatment effect on the amyotrophic lateral sclerosis is achieved, and therefore, the composition used for treating the amyotrophic lateral sclerosis and having excellent treatment effect is provided, and the composition can obviously delay disease progression of the amyotrophic lateral sclerosis.

Description

technical field [0001] The invention belongs to the field of medicines, and in particular relates to a combination medicine composition for treating amyotrophic lateral sclerosis, a preparation method and application thereof. Background technique [0002] Amyotrophic lateral sclerosis (Amyotrophic Lateral Scleroisi, ALS), also known as motor neuron disease (MND), commonly known as "gradual freezing disease", is more common in men, and the age of onset is generally 40-70 years old. Motor neurons in the cerebral cortex, brainstem, and spinal cord progressively degenerate, leading to neurodegenerative diseases such as muscle weakness, atrophy, speech, swallowing, and respiratory dysfunction. Although there are considerable individual differences in the clinical manifestations of patients and the progression speed of the disease, there is no exception for progressive aggravation. More than 60% of patients die within 3 years of onset, and about 10% of patients can survive for mor...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/216A61K31/355A61K31/375A61K31/122A61K31/661A61P25/28
CPCA61P25/28A61K31/122A61K31/216A61K31/355A61K31/375A61K31/661A61K2300/00A61K9/0019A61K9/2054A61K9/19A61K9/1652A61K9/20A61K9/48
Inventor 张洁陈晓光杨华蓉李文斌
Owner SICHUAN JIUZHANG BIO TECH CO LTD
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