SERS (Surface Enhanced Raman Scattering) unit, and preparation method and application thereof

An etching method, nanoparticle technology, applied in surface reactive electrolytic coating, nanotechnology for sensing, nanotechnology for materials and surface science, etc. application and other issues, to achieve the effects of low preparation cost, high uniformity and convenient operation

Pending Publication Date: 2018-11-20
苏州英菲尼纳米科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the SERS technology with ultra-high sensitivity (even single-molecule detection) has been developed for nearly 50 years, it cannot be widely used in the detection of trace substances due to the limited availability of low-cost and high-quality chips.

Method used

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  • SERS (Surface Enhanced Raman Scattering) unit, and preparation method and application thereof
  • SERS (Surface Enhanced Raman Scattering) unit, and preparation method and application thereof
  • SERS (Surface Enhanced Raman Scattering) unit, and preparation method and application thereof

Examples

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preparation example Construction

[0053] In some embodiments, the preparation method of the SERS unit of the present invention includes: firstly, a porous metal oxide layer is made on the surface of the metal substrate by electrochemical anodic oxidation, so that the metal substrate becomes the first layer composed of metal and composed of metal oxide to form a SERS unit substrate with a plurality of nano-depressions on the surface. Secondly, the SERS unit substrate is immersed in a dispersion liquid dispersed with specific concentrations of SERS active nanoparticles, and the SERS active nanoparticles are self-assembled into multiple nano-depressions to form nanoparticle aggregates limited by the nano-depressions. The size of the nanoparticle aggregate and the number of nanoparticles contained in the nanoparticle aggregate can be controlled by the concentration of the nanoparticle dispersion, self-assembly time and other conditions. Preferably, the preparation method may further include: controlling the time f...

Embodiment 1

[0065] This embodiment provides a SERS chip, which is composed of one SERS unit. The size of the SERS unit is 4mm*4mm, the SERS unit includes a substrate with a plurality of nano-depressions discretely distributed on the surface, and nano-particle aggregates dispersed in the nano-depressions, each nano-particle aggregate is composed of a plurality of nano-particles Aggregations are formed, and each nanoparticle aggregate is confined by a corresponding nano-depression.

[0066] The SERS unit was prepared by the following steps:

[0067] (1) Provide the substrate: take the alumina template prepared by the anodic oxidation method (the thickness is 0.3mm, and its SEM image is as follows Figure 5 As shown, a plurality of nano-depressions are microscopically disordered and macroscopically uniformly distributed on the entire surface of the substrate, and the number of nano-depressions per square centimeter on the substrate is about 10 8 ~10 9 One, the diameter of the nano-depress...

Embodiment 2

[0072] This embodiment provides a SERS chip, which is basically the same as in Embodiment 1, except that the dipping time is controlled to be 4h during preparation. The SEM image of the SERS chip obtained in this example is as follows Figure 9 As shown, it can be seen that nanoparticle aggregates are formed in each nano-depression, most of the nanoparticle aggregates contain a plurality of spherical nanoparticles aggregated together, and the number of nanoparticles contained in each nanoparticle aggregate is 6 to 10 pieces, the average number is about 8 pieces. Nanoparticles in each nanodepression are basically arranged in a single layer.

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Abstract

The invention discloses an SERS (Surface Enhanced Raman Scattering) unit which comprises a substrate having a plurality of nano-recesses scattered on the surface thereof, and a plurality of nano-particle aggregates, each nano-particle aggregate is formed by aggregating a plurality of nano-particles, and each nano-particle aggregate is limited by a corresponding nano-recess. The invention also discloses a preparation method of the SERS unit. The SERS unit can be obtained by impregnating the substrate with nano-recesses into a dispersion containing nano-particles, and then self-assembling the nano-particles. The SERS unit can be directly applied as an SERS chip, has the advantages of high SERS activity, high uniformity, excellent stability, high batch reproducibility and the like, is easy toprepare, can be produced in a large area and on a large scale, and has a broad business prospect.

Description

technical field [0001] The present invention relates to surface-enhanced Raman (Surface-Enhanced Raman Scattering, SERS) technology, in particular to a chip for surface-enhanced Raman detection and its preparation method and application. Background technique [0002] Surface-Enhanced Raman (Surface-Enhanced Raman Scattering, SERS) is through the interaction between the probe molecules on or near the surface of the metal nanostructure and the metal surface to generate Raman-enhanced scattering (Surface Plasmon Resonance, SPR), and SERS produces The Raman signal will be enhanced by 10 compared with ordinary Raman scattering 3 -10 14 times. Compared with other spectral detection methods, SERS has three obvious advantages of high sensitivity, high selectivity and loose detection conditions, and can be widely used in many fields such as trace analysis, single molecule detection, biomedical detection, surface adsorption and catalytic reaction. [0003] The level of SERS activit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/65B82Y40/00B82Y30/00
CPCG01N21/658C25D11/02C25D11/04B82Y30/00B82Y40/00C25D11/24C25D11/26C25D11/045B82Y15/00
Inventor 郭清华孙海龙
Owner 苏州英菲尼纳米科技有限公司
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