48results about How to "Good batch-to-batch reproducibility" patented technology

The invention provides a deep processing method of small-leaf Kuding tea. The method takes local small-leaf tea in Guizhou as tea raw material, and performs steps of picking, rinsing, soaking, withering, twisting, fermenting, drying and others; the method is creatively improved on the basis of a traditional tea manufacturing technique; the prepared tea leaf is good in batch reproducibility; the tea leaf is bright green in soup, clear and bright in color, pure in fragrance, slightly bitter and sweet in taste; the leaf back is green, fresh and soft; therefore, the small-leaf Kuding tea meets the requirement of the first-grade tea.

The invention provides a pretreatment method for alkaloid in Anisodus tanguticus. The method is suitable for sample pretreatment in separation, preparation and qualitative and quantitative operation of alkaloid in Anisodus tanguticus. The method mainly includes pulverizing Anisodus tanguticus medicinal material, adding ethanol for extraction, collecting extracting solution, concentrating to obtain extract, tanking the extract, performing selective enrichment to the alkaloid in crude alkaloid by silica gel-based strong cation exchange (SCX) solid phase extraction (SPE) material to obtain alkaloid enriched segment for use in separation analysis and separation preparation of alkaloid in Anisodus tanguticus. The invention has good selectivity and high alkaloid content in fraction, and can greatly improve separation analysis and separation preparation efficiency of alkaloid in Anisodus tanguticus. The pretreatment method has high repeatability and good operability in operating process, is easy for realizing standardization and industrialization, and has a certain directing significance for selectively obtaining alkaloid enriched fraction from Anisodus tanguticus.

The invention discloses an SERS (Surface Enhanced Raman Scattering) unit which comprises a substrate having a plurality of nano-recesses scattered on the surface thereof, and a plurality of nano-particle aggregates, each nano-particle aggregate is formed by aggregating a plurality of nano-particles, and each nano-particle aggregate is limited by a corresponding nano-recess. The invention also discloses a preparation method of the SERS unit. The SERS unit can be obtained by impregnating the substrate with nano-recesses into a dispersion containing nano-particles, and then self-assembling the nano-particles. The SERS unit can be directly applied as an SERS chip, has the advantages of high SERS activity, high uniformity, excellent stability, high batch reproducibility and the like, is easy toprepare, can be produced in a large area and on a large scale, and has a broad business prospect.

The invention discloses a beta-cyclodextrin derivative and a preparation method thereof and a polyurea-bond cyclodextrin chiral stationary phase prepared from the beta-cyclodextrin derivative. The beta-cyclodextrin derivative has a molecular formula of [((CH3)2C6H3NHCO)14C42H49O28)(N3)7] and has a structural formula as shown in a formula (I) which is described in the specification. The beta-cyclodextrin derivative is used as a chiral selector and undergoes a Staudinger reaction with ammoniated silica gel so as to obtain the novel poly-bonded cyclodextrin chiral stationary phase. The chiral stationary phase provided by the invention has good stability in a mobile phase with strong polarity and high water content, has good selectivity with regard to chiral compounds and can be applied in high performance liquid chromatography (HPLC), simulated moving bed chromatography (SMB), supercutical fluid chromatography (SFC), etc.

The invention belongs to the technical of organic photoelectric material, and more specifically relates to a carbazole nine-element condensed ring central core-containing D(A-Ar)4 type organic photoelectric material, and a preparation method and applications thereof. According to the preparation method, a three-element carbazole central ring unit and a thiophene derivative are subjected to coupling, ring closure reaction and coupling reaction are adopted so as to obtain an aromatic compound derivative containing a carbazole based nine-element condensed ring coplanar structure, and a D(A-Ar)4 butterfly type organic small molecular photovoltaic material containing a carbazole nine-element condensed ring center donor core. The aromatic compound derivative containing a carbazole based nine-element condensed ring coplanar structure, and the D(A-Ar)4 butterfly type organic small molecular photovoltaic material possesses high heat stability and excellent plane performance. The structure witha wide spectrum absorption range and an appropriate energy level is promising to be taken as organic solar energy cell donors or receptor materials.

The invention provides a methotrexate oral disintegrating tablet for rapid disintegrating in oral cavity without water, which is prepared by comminuting methotrexate, sodium carboxymethylstarch, crystalline cellulose, mannitol, magnesium stearate, passing through 100 mesh sieves, mixing homogeneously, and pelleting directly.

The invention discloses a palbociclib pharmaceutical composition, comprising palbociclib or its medicinal salt and a pharmaceutically acceptable auxiliary material, wherein the palbociclib or its medicinal salt is 50-150 Mum, and the medicinal salt includes isethionates, hydrochlorides, sulfates or benzene sulfonates.Direct mixing and capsuling process of raw and auxiliary materials is used for the pharmaceutical composition provided herein, the biological availability is high, product quality stability is good, the technical process is easy to control, inter-batch reproducibility is good, and the composition is easy to industrialize.

The invention relates to the technical field of tablet preparation, in particular to a preparation technology of roflumilast film-coated tablets. The preparation technology comprises the following steps of S1, micronizing roflumilast, and filtering starch, lactose and magnesium stearate through an 80-mesh sieve for later use; S2, dissolving hydroxypropyl methylcellulose into water to prepare aqueous solutions of different concentrations for later use; S3, mixing a mixture obtained by multiple equal incremental blending of 1 g of roflumilast and 15 g of starch with 398 g of lactose and remaining starch in the step S1; S4, adding an adhesive for granulation after mixing is ended; S5, preparing wet granules from prepared soft materials; S6, drying the wet granules obtained in the step S5; S7,carrying out granulation on the dried granules through a 20-mesh sieve; and S8, carrying out tableting by using a shallow concave mold with the diameter of 9 mm. When granulation is carried out by using the method, the granulation condition is good, the granules are uniform, the tablets are bright and clean, and the friability of tablet cores meets the requirements. Samples meeting the standard can be prepared through the method, the interbatch reproducibility is good, the samples are equivalent to originally commercially available products in quality, and production can be smoothly implemented through the preparation technology of a prescription.

The invention relates to the technical field of bending, in particular to a forming process for a net corrugated board structure of a cloth dyeing machine. The process includes the following steps that firstly, a board is cut into flat plates according to the calculated corrugated board unfolding size; secondly, the flat plates are polished, and protection films are attached to the flat plates; thirdly, the flat plates are placed on a working table of a bending machine and are pressed and bent through the bending machine and a pressing and bending die so that a plurality of arc-shaped protruding strips (1) can be formed in the middles of the flat plates; fourthly, the two sides of the flat plates are bent inwards through the bending machine and an edge bending die; and fifthly, greasy dirt processing is conducted on the surfaces of the flat plates. The process has the beneficial effects that the bending machine and the dies are adopted, continuous hydraulic forming is conducted on the size-fixed board, efficiency is high, surface scratches are fewer, the batch repeatability is high, and products are stable.

The invention belongs to the field of pharmaceutical preparations, and particularly relates to an empagliflozin metformin sustained release preparation and a preparation method thereof. An empagliflozin pellet core is a quick release part, a metformin hydrochloride pellet core is a sustained release part, the two pellet cores are coated with isolation layers respectively, and then the two drug-loaded pellets are mixed and filled into capsules. The invention further discloses the preparation method of the empagliflozin metformin sustained release preparation. The preparation method comprises the steps that (1), the metformin hydrochloride pellet core is prepared through an extrusion and spheronization process; (2), the empagliflozin quick release pellet core is prepared through the extrusion and spheronization process; (3), the two drug-loaded pellet cores are coated with the isolation layers respectively; and (4), the two drug-loaded pellets are filled into the capsules according to a certain proportion. The preparation process is good in stability, simple, high in production efficiency and suitable for industrial mass production.

The invention relates to an application of a CCA-CD co-assembly in the preparation of a macromolecular toxin detoxification drug. The co-assembly CCA-CD can be used for effectively complexing melittin, spider venom and snake venom and relieving the cytotoxicity of melittin, spider venom and snake venom, and has the potential of treating poisoning of toxic macromolecules. Each component of the CCA-CD is clear in chemical structure and good in batch reproducibility, and the CCA-CD has very high chemical stability and thermal stability, does not influence the activity of important proteins in a living body, and has good biocompatibility.

The invention discloses a preparation method of a naphthaloyl-bridged bis-β-cyclodextrin bonded chiral stationary phase, using naphthaloyl-bridged bis-β-cyclodextrin as a chiral stationary phase ligand, SBA-15 The naphthaloyl bridged bis-cyclodextrin bonded chiral separation material is a silica gel substrate, and the naphthaloyl bridged biscyclodextrin stationary phase of the present invention has obvious advantages in chiral separation. The traditional single β-cyclodextrin stationary phase cannot resolve substances such as flavanone (a), 4’-hydroxyflavanone (c), praziquantel (d), and imazalil (f). The naphthaloyl bridged double β-cyclodextrin stationary phase prepared by the invention can be completely resolved.