3results about How to "Good batch-to-batch reproducibility" patented technology

The application provides a liquid-phase synthesis method of silk fibroin peptide and belongs to the technical field of organic materials. The silk fibroin peptide is shown as formula (I). The application adopts a GA+GA convergent condensation strategy, uses N-Boc-glycine and alanine benzyl ester hydrochloride as starting materials, sequentially constructs dipeptide, tetrapeptide through condensation, deprotection and recondensation, and condenses with a previously prepared GS dipeptide to obtain a hexapeptide skeleton, and finally removes the protective group to obtain the target product. The application determines the optimal process parameters by screening the connection sequence and the condensing agent system, and the purity and yield of each intermediate and final product are high. The application is simple to operate, does not need chromatographic purification, has good batch stability, is easy to scale up, and provides an economic and reliable technical scheme for efficient preparation of silk fibroin characteristic peptide segments. Formula (I)

This invention proposes a graphyne / gold nanocomposite material, its preparation method, and its application. The graphyne / gold nanocomposite material comprises graphyne and gold nanoparticles loaded on its surface. Graphyne can enrich the gold nanoparticles, and the gold nanoparticles loaded on the graphyne can generate a localized surface plasmon resonance effect, thereby providing a SERS signal response. The substrate of this invention exhibits good SERS signal response to dyes and plant toxins, and the substrate enhancement effect is stable and highly reproducible, ensuring the accuracy and reliability of the detection results. This invention also proposes the application of the above-mentioned graphyne / gold nanocomposite material as a surface-enhanced Raman scattering substrate for detecting isoxazole / tryptamine toxins in mushrooms. This enables rapid detection of psilocybin and amatoxins in complex matrices of fungal samples; it can be used for rapid screening of highly poisonous mushrooms and their products in food safety, showing significant application prospects.

This invention discloses a theophylline sustained-release tablet and its preparation method, belonging to the field of pharmaceutical formulation technology. The technical solution includes the following steps: 1) preparation of a pore-forming agent; 2) preparation of a blocking agent; 3) premixing: anhydrous theophylline and a hydrophilic gel framework material are premixed to obtain a premixed powder; 4) first granulation: the prepared pore-forming agent aqueous solution is added to the premixed powder, granulated, dried, and sized to obtain granules one; 5) second granulation: the prepared blocking agent ethanol solution is added to granules one, granulated, dried, and sized to obtain granules two; 6) tableting: a lubricant is added to granules two, and tablets are compressed using a tableting machine to obtain theophylline sustained-release tablets. This invention provides a theophylline sustained-release tablet and its preparation method with good sustained-release effect, long duration of action, and good batch-to-batch repeatability. The preparation method is simple and requires no heating; the prepared theophylline sustained-release tablets show good compatibility with the reference formulation.