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Perphenazine orally disintegrating tablet and preparation method thereof

A technology of orally disintegrating tablets and disintegrants, applied in pill delivery, neurological diseases, drug combinations, etc., can solve problems such as slow dissolution rate, unloaded, affecting drug absorption and bioavailability

Inactive Publication Date: 2006-07-26
马晶
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its dissolution rate is slow, affecting the absorption and bioavailability of the drug
[0004] Orally disintegrating tablet is a new type of oral preparation. More than a dozen products have been launched at home and abroad, but this dosage form is not recorded in the pharmacopoeia of various countries.

Method used

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  • Perphenazine orally disintegrating tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Perphenazine 4.0g

[0043] Sodium carboxymethyl starch 13.1g

[0044] Microcrystalline Cellulose 27.3g

[0045] Micronized silica gel 3.6g

[0046] Magnesium stearate 0.7g

[0047] Aspartame 0.1g

[0048] Made into 1000 pieces

[0049] Perphenazine, microcrystalline cellulose, sodium carboxymethyl starch, micropowder silica gel, magnesium stearate, etc. are all passed through a 100-mesh sieve.

[0050] Weigh 4.0 grams of perphenazine, first mix with 13.1 grams of sodium carboxymethyl starch in equal amounts, then add 27.3 grams of microcrystalline cellulose and mix thoroughly, then add 3.6 grams of micropowder silica gel, 0.7 grams of stearic acid Magnesium and aspartame 0.1 g, mix well. Detect the percentage content of perphenazine in the mixed powder, calculate the weight of the tablet, and press it into a tablet. In this way, 1000 perphenazine orally disintegrating tablets can be pressed out.

[0051] Its disintegration time is...

Embodiment 2

[0053] Perphenazine 9.0g

[0054] Sodium carboxymethyl starch 18.0g

[0055] Microcrystalline Cellulose 45.0g

[0056] Micronized silica gel 4.5g

[0057] Magnesium stearate 0.5g

[0058] Aspartame 0.1g

[0059] Made into 1000 pieces

[0060] Perphenazine, microcrystalline cellulose, sodium carboxymethyl starch, micropowder silica gel, magnesium stearate, etc. are all passed through a 100-mesh sieve.

[0061] Weigh 9.0 grams of perphenazine, first mix with 18.0 grams of sodium carboxymethyl starch in equal increments, then add 45.0 grams of microcrystalline cellulose and mix thoroughly, then add 4.5 grams of micropowder silica gel, 0.5 grams of stearic acid Magnesium and aspartame 0.1 g, mix well. Detect the percentage content of perphenazine in the mixed powder, calculate the weight of the tablet, and press it into a tablet. In this way, 1000 perphenazine orally disintegrating tablets can be pressed out.

[0062] Its disintegration ...

Embodiment 3

[0065] Perphenazine 6.0g

[0066] Sodium carboxymethyl starch 23.0g

[0067] Microcrystalline Cellulose 57.0g

[0068] Micronized silica gel 5.1g

[0069] Magnesium stearate 0.9g

[0070] Aspartame 0.3g

[0071] Made into 1000 pieces

[0072] Perphenazine, microcrystalline cellulose, sodium carboxymethyl starch, micropowder silica gel, magnesium stearate, etc. are all passed through a 100-mesh sieve.

[0073] Weigh 6.0 grams of perphenazine, first mix with 23.0 grams of sodium carboxymethyl starch in equal increments, then add 57.0 grams of microcrystalline cellulose and mix thoroughly, then add 5.1 grams of micropowder silica gel, 0.9 grams of stearic acid Magnesium and aspartame 0.3 g, mix well. Detect the percentage content of perphenazine in the mixed powder, calculate the weight of the tablet, and press it into a tablet. In this way, 1000 perphenazine orally disintegrating tablets can be pressed out.

[0074] Its disintegration ...

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Abstract

The invention discloses a Perphenazine oral disintegrating tablet, which is prepared from 2.0-10.0 wt% of Perphenazine, 20.0-30.0wt% of sodium carboxymethylstarch, 50.0-70.0wt% of crystalline cellulose, 5.0-10.0wt% of miropowdered silica gel, 0.5-2.0wt% of magnesium stearate, and 0.1-0.5 wt% of polysorbate through passing through 100 mesh sieves, mixing homogenously, and carrying out powder direct pelleting method to obtain the composition.

Description

Technical field: [0001] The invention relates to a pharmaceutical composition containing perphenazine, and relates to an improved technology for perphenazine oral preparations. technical background: [0002] Perphenazine is a phenothiazine derivative and is a commonly used typical antipsychotic drug. It is mainly used to treat schizophrenia and other psychotic disorders, and has a good effect on symptoms such as hallucinations, delusions, thinking disorders, apathy, stupor, and anxiety. And it has little side effects on the liver and cardiovascular system, and it is often used clinically to treat elderly patients or mental patients with liver and cardiovascular system diseases or patients with cardiovascular adverse reactions caused by other antipsychotic drugs. In addition, because of its weak sedative effect, it has little effect on blood pressure. It is suitable for organic mental illness, senile mental disorder and aggressive behavior disorder in children. It can also...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/5415A61K9/20A61P25/18
Inventor 马晶
Owner 马晶
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