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Application of CCA-CD co-assembly in preparation of macromolecular toxin detoxification drug

A co-assembly, drug technology, applied in the direction of drug combination, nano-drugs, antidote, etc., to achieve high chemical stability and thermal stability, clear chemical structure, good biocompatibility effect

Active Publication Date: 2021-10-19
NANKAI CANGZHOU BOHAI NEW AREA GREENING CHEM RES CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to solve the specific and strong bonding of macromolecular toxins, thereby effectively alleviating their toxicity

Method used

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  • Application of CCA-CD co-assembly in preparation of macromolecular toxin detoxification drug
  • Application of CCA-CD co-assembly in preparation of macromolecular toxin detoxification drug
  • Application of CCA-CD co-assembly in preparation of macromolecular toxin detoxification drug

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Embodiment Construction

[0031] The present invention will be further described in detail below through the specific examples, the following examples are only descriptive, not restrictive, and cannot limit the protection scope of the present invention with this.

[0032] A co-assembly CCA-CD capable of heteropolyvalent recognition has the potential to treat macromolecular toxin poisoning such as melittin. Carboxyl-modified amphiphilic calixarene CCA and amphiphilic cyclodextrin CD are the building blocks of the heteropolyvalent recognition platform,

[0033] Among them, the chemical formula of CCA is C 100 h 150 o 15 , the chemical formula of CD is C 182 h 350 o 56 S 7 , the molar ratio of the two substances is 1:1. The supramolecular assembly is constructed through weak π-π interactions and hydrophobic interactions. Its scale is nanoscale and its shape is spherical vesicles. The structural formulas of CCA and CD are as follows:

[0034]

[0035] The preparation steps are as follows:

[00...

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Abstract

The invention relates to an application of a CCA-CD co-assembly in the preparation of a macromolecular toxin detoxification drug. The co-assembly CCA-CD can be used for effectively complexing melittin, spider venom and snake venom and relieving the cytotoxicity of melittin, spider venom and snake venom, and has the potential of treating poisoning of toxic macromolecules. Each component of the CCA-CD is clear in chemical structure and good in batch reproducibility, and the CCA-CD has very high chemical stability and thermal stability, does not influence the activity of important proteins in a living body, and has good biocompatibility.

Description

technical field [0001] The invention belongs to the technical field of nano-supramolecular materials, and relates to a supramolecular co-assembly, especially a nano-supramolecular co-assembly utilizing amphiphilic calixarene CCA and amphiphilic cyclodextrin CD, through heteropolyvalent interactions, and rich in alkaline The macromolecular toxins of amino acids and hydrophobic amino acids achieve strong bonds and can be used for the detoxification of such macromolecular toxins. Background technique [0002] Poisoning is one of the main causes in the emergency room and intensive care unit. For severe poisoning, the current treatment methods mainly include gastric lavage, enema, dialysis, etc., see: 1) Megarbane, B.; Oberlin, M.; Alvarez, J.C.; etal.Ann.Intensive Care 2020,10,157.2) Mokhlesi,B.; Leiken,J.B.; Murray,P.; biological activity of the substance. This method has fewer requirements for toxins (such as the distribution range of toxins, molecular weight, affinity with ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/795A61P39/02C08G83/00C08B37/16B82Y5/00
CPCA61K31/795A61P39/02C08G83/008C08B37/0012B82Y5/00
Inventor 郭东升潘雨辰岳宇昕李华斌
Owner NANKAI CANGZHOU BOHAI NEW AREA GREENING CHEM RES CO LTD
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