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Breviscapine orally disintegrating tablet and preparation method thereof

A technology of orally disintegrating tablets and breviscapine, which can be used in pharmaceutical formulations, medical preparations containing active ingredients, anti-toxins, etc., and can solve problems such as difficulty swallowing and speed up the dissolution rate

Inactive Publication Date: 2006-07-26
马晶
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, for stroke, hemiplegia patients and bedridden patients who have difficulty swallowing, the solution of the present invention is to formulate breviscapine into a breviscapine orally disintegrating tablet that can be quickly disintegrated in the oral cavity without water, which is convenient to use , which can not only speed up the dissolution rate, but also help the drug to take effect quickly

Method used

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  • Breviscapine orally disintegrating tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Example 1 wt wt%

[0052] Breviscapine 29.8g 35.0

[0053] Sodium carboxymethyl starch 9.4g 11.0

[0054] Microcrystalline Cellulose 40.8g 48.0

[0055] Micronized silica gel 4.25g 5.0

[0056] Magnesium stearate 0.85g 1.0

[0057] Aspartame 0.1g 0.1

[0058] Made into 1000 pieces

[0059] Breviscapine, microcrystalline cellulose, sodium carboxymethyl starch, micronized silica gel, magnesium stearate, etc. are all micronized to less than 75 microns.

[0060] Weigh 29.8 grams of breviscapine, first mix with 9.4 grams of sodium carboxymethyl starch in equal increments, then add 40.8 grams of microcrystalline cellulose and mix thoroughly, then add 4.25 grams of micropowder silica gel, 0.85 grams of stearic acid Magnesium and aspartame 0.1 g, mix well. Detect the percentage content of breviscapine in the mixed powder, calculate the weight of the tablet, and press it into a tablet. In this way, 1000 breviscapine orally disintegrating tabl...

Embodiment 2

[0062] Example 2 wt wt%

[0063] Breviscapine 20g 24.6

[0064] Sodium carboxymethyl starch 9.5g 11.7

[0065] Microcrystalline cellulose 46.2g 56.9

[0066] Micronized silica gel 4.5g 5.6

[0067] Magnesium stearate 0.9g 1.1

[0068] Aspartame 0.1g 0.1

[0069] Made into 1000 pieces

[0070] Breviscapine, microcrystalline cellulose, sodium carboxymethyl starch, micronized silica gel, magnesium stearate, etc. are all micronized to less than 75 microns.

[0071] Weigh 20 grams of breviscapine, first mix with 9.5 grams of sodium carboxymethyl starch in equal amounts, then add 46.2 grams of microcrystalline cellulose and mix thoroughly, then add 4.5 grams of micropowder silica gel, 0.9 grams of stearic acid Magnesium and aspartame 0.1 g, mix well. Detect the percentage content of breviscapine in the mixed powder, calculate the weight of the tablet, and press it into a tablet. In this way, 1000 breviscapine orally disintegrating tablets can b...

Embodiment 3

[0073] Example 3 wt %

[0074] Breviscapine 17.5g 21.1

[0075] Sodium carboxymethyl starch 10.5g 12.7

[0076] Microcrystalline cellulose 45.8g 55.2

[0077] Micronized silica gel 8.0g 9.6

[0078] Magnesium stearate 1.0g 1.2

[0079] Aspartame 0.2g 0.2

[0080] Made into 1000 pieces

[0081] Breviscapine, microcrystalline cellulose, sodium carboxymethyl starch, micronized silica gel, magnesium stearate, etc. are all micronized to less than 75 microns.

[0082] Weigh 17.5 grams of breviscapine, first mix with 10.5 grams of sodium carboxymethyl starch in equal increments, then add 45.8 grams of microcrystalline cellulose and mix thoroughly, then add 8.0 grams of micropowder silica gel, 1.0 grams of stearic acid Magnesium and aspartame 0.2 g, mix well. Detect the percentage content of breviscapine in the mixed powder, calculate the weight of the tablet, and press it into a tablet. In this way, 1000 breviscapine orally disintegrating table...

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PUM

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Abstract

The invention discloses a Breviscapine oral disintegrating tablet, which comprises 21.0-35.0 wt% of Breviscapine, 11.0-15.0.0wt% of sodium carboxymethylstarch, 45.0-60.0 wt% of crystalline cellulose, 1.0-2.0 wt% of magnesium stearate, 5.0-10.0 wt% of miropowdered silica gel, and 0.1-0.5wt% of Aspartame. the relative weight ratio of Breviscapine and sodium carboxymethylstarch is 1:0.3-1:0.7.

Description

Technical field: [0001] The invention relates to a traditional Chinese medicine preparation, and more specifically relates to an improved technology for an oral preparation of scutellarin. technical background: [0002] Erigeron breviscapus is an active ingredient of flavonoids extracted from Erigeron breviscapus. Including scutellarin and scutellarin, with scutellarin (4,5,6-trihydroxyflavone-7 glucuronide) as the main component. Pharmacological studies have shown that breviscapine can increase cerebral blood flow, reduce cerebrovascular resistance, improve cerebral circulation, relieve arteriolar spasm, improve blood-brain barrier permeability, and antagonize myocardial ischemia-reperfusion injury. It can delay aging, and can significantly improve memory reproduction disorders caused by scopolamine, ethanol, etc., and significantly strengthen learning ability; at the same time, it can increase myocardial blood flow, improve the phagocytic immune function of antibody macro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K9/20A61P9/10A61P25/00A61P39/06
Inventor 马晶
Owner 马晶
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