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Ophthalmic gel and preparation method and application thereof

A technology of ophthalmic gel and gel, which is applied in the field of medicine, can solve the problems of low efficiency, achieve the effects of less toxic and side effects, strong penetrating power, and increase cerebral blood flow

Inactive Publication Date: 2018-11-30
GUANGDONG LEWWIN PHARM RES INST CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Aiming at the problem that existing curcumin ophthalmic gel is not efficient in inhibiting neovascularization, the object of the present invention is to provide a kind of ophthalmic gel that can well inhibit ocular neovascularization and has little toxic and side effects. Simultaneously, the present invention also provides the preparation method and application of the ophthalmic gel

Method used

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  • Ophthalmic gel and preparation method and application thereof
  • Ophthalmic gel and preparation method and application thereof
  • Ophthalmic gel and preparation method and application thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0022] The present invention also provides the ophthalmic gel, wherein the pharmaceutically acceptable excipients include thickeners, bacteriostatic agents, pH value adjusters and osmotic pressure adjusters, and the preparation method includes the following steps: using an appropriate amount of water for injection Dissolve the thickener and let it cool to obtain liquid A; then dissolve the bacteriostatic agent with an appropriate amount of water for injection, then add curcumin, polycarbophil and Panax notoginseng to obtain liquid B; then mix liquid A and liquid B , measure the pH value and osmotic pressure of the solution, add a pH value regulator and an osmotic pressure regulator to adjust the pH value to 5.5-7.5 and the osmotic pressure to 250-350mOsmol / kg, and add the remaining water for injection.

[0023] Dissolve the thickening agent with an appropriate amount of water for injection and let it cool to obtain liquid A; then dissolve the pH adjuster and bacteriostatic agen...

Embodiment 1-3

[0027] Table 1: Example 1-3 ophthalmic gel formulation table

[0028]

[0029] According to the technical scheme of the present invention, the types of adjuvants that can be selected for preparing curcumin ophthalmic gel are not limited to those listed in the table above, and can also have the following multiple options:

[0030] According to the technical scheme of the present invention, the varieties of adjuvants that can be selected for preparing curcumin ophthalmic gel are not limited to the varieties listed in the above table, and can also have the following multiple options:

[0031] Wherein, the variety selection and dosage of the bacteriostatic agent are the same as those in Example 1-3.

[0032] The thickener is selected from one of hypromellose, methylcellulose, sodium hyaluronate, polyvinyl alcohol, polyvinylpyrrolidone, carboxymethylcellulose, carbomer, chondroitin sulfate or any of the varieties. combination.

[0033] Use a pH regulator to adjust the pH value...

experiment example 1

[0035] Experimental Example 1 Stability test of curcumin ophthalmic gel

[0036] Accelerated test: The 0.005% curcumin ophthalmic gel prepared by the method of Example 2 of the present invention is put into a constant temperature and humidity box under commercially available packaging conditions, at a temperature of 40 ℃ ± 2 ℃ and a relative humidity of 25% ± 5 % conditions, take samples on time in the 1st, 2nd, 3rd, and 6th months, respectively, and measure according to the draft quality standard. The results are shown in Table 2:

[0037] Table 2: Accelerated Test Data Sheet

[0038]

[0039]Long-term test: adopt the 0.005% curcumin ophthalmic gel prepared by the method of Example 2 of the present invention under the condition of commercially available packaging, put it into a constant temperature and humidity box, at a temperature of 25 ℃ ± 2 ℃ and a relative humidity of 40% ± 5 % conditions, take samples on time at the 3rd, 6th, 9th, 12th, and 18th months, respectivel...

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Abstract

The invention discloses an ophthalmic gel. The ophthalmic gel comprises the preparation raw materials of curcumin, a mucosal adhesive polymer drug release system, water for injection and pharmaceutically acceptable auxiliary materials, wherein the mucosal adhesive polymer drug release system comprises panax notoginseng saponins and polycarbophil; and every 100ml ophthalmic gel comprises 0.001-0.01g part of curcumin, and the weight part ratio of the curcumin, the panax notoginseng saponins and the polycarbophil is that curcumin:panax notoginseng saponins:polycarbophil = 1:(0.3-3):(0.5-2). The ophthalmic gel has a good effect of inhibiting ocular neovascularization, and is non-irritating and safe. The invention further provides a preparation method and application of the ophthalmic gel.

Description

technical field [0001] The invention relates to the field of medicine, and more particularly, to an ophthalmic gel and a preparation method and application thereof. Background technique [0002] Ocular neovascular disease is one of the main causes of blindness, which can be found in a variety of fundus diseases. The exact pathogenesis is not fully understood. The prevention and treatment of neovascularization is the key to clinical treatment and the core issue of basic research. [0003] As one of the most important active components of turmeric, curcumin has antioxidant, anti-tumor, anti-inflammatory, anti-viral, inhibiting angiogenesis, protecting liver and kidney and other pharmacological effects. It has a good clinical application prospect. For ocular diseases, topical administration has many advantages over systemic administration. Subconjunctival and intravitreal injections can achieve effective drug concentrations in the ocular tissue, but intraocular injection is a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/258A61K9/06A61K47/32A61P27/02A61P7/02A61P27/12A61K31/12
CPCA61K9/0048A61K9/06A61K31/12A61K36/258A61K47/32A61P7/02A61P27/02A61P27/12A61K2300/00
Inventor 郭健敏杨威代彩玲
Owner GUANGDONG LEWWIN PHARM RES INST CO LTD
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