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Composition containing ginkgo terpene lactones and medical application thereof

A technique of ginkgolidene and ginkgoditerpene lactones, which is applied in the field of preparation of drugs for the prevention and/or treatment of venous thromboembolic diseases, and can solve the problems of high liver and kidney toxicity, high cost of use, and high risk of bleeding, To achieve the effect of exact curative effect, reasonable price, and expanded application range

Active Publication Date: 2018-12-04
CHENGDU BAIYU PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although saban drugs have demonstrated good anticoagulant effects in clinical practice, they still face problems such as high risk of bleeding, high liver and kidney toxicity, and high cost of use.

Method used

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  • Composition containing ginkgo terpene lactones and medical application thereof
  • Composition containing ginkgo terpene lactones and medical application thereof
  • Composition containing ginkgo terpene lactones and medical application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1 Anticoagulant Effect of Ginkgolide Lactone Composition on Rabbit Traumatic Limb Deep Vein Thrombosis Model

[0030] Materials and Methods

[0031] 1.1 Experimental animals

[0032] 500 grade I Japanese big-eared white rabbits (4 for spare), weighing 2.0-3.0 kg during the test, all male.

[0033] 1.2 Experimental drugs

[0034] Bilobalide, ginkgolide A, ginkgolide B, ginkgolide C and ginkgolide composition 1-24, the detailed prescription is as follows:

[0035] Table 1. Detailed ratio table of ginkgolide lactone prescription

[0036]

[0037]

[0038] 1.3 Reagents and instruments

[0039] instrument:

[0040] (1) Rabbit weighing inspection instrument

[0041] ACS-15LED electronic platform scale, resolution value 1g, maximum weighing 6kg, instrument number BKY-YB-002, produced by Shanghai Yingpai Scale Co., Ltd., used to weigh rabbits.

[0042] (2) Pathological examination equipment

[0043] Germany Sartorius BS124S electronic balance (division val...

Embodiment 2

[0082] Example 2 Anticoagulant effect of ginkgolide and saban pharmaceutical composition on traumatic limb deep vein thrombosis model in rabbits

[0083] Materials and Methods

[0084] 2.1 Experimental animals and modeling methods

[0085] Same as Example 1

[0086] 2.2 Experimental drugs and dosing regimens

[0087] 1:1 bilobalide and ginkgolide, 2:1 bilobalide: ginkgolide B, rivaroxaban, apixaban, edoxaban and combinations thereof.

[0088] Due to the different human clinical recommended doses of rivaroxaban, apixaban, and edoxaban, refer to their instructions: daily clinical recommended dose of rivaroxaban: 10 mg; daily clinical recommended dose of apixaban: 2.5 mg and The maximum clinically recommended dose of edoxaban: 60mg / day, and the clinically recommended dose of combined drugs shall be converted according to the equivalent dose.

[0089] Dosage is shown in Table 5 below

[0090]

[0091] 2.3 Reagents and instruments

[0092] Same as Example 1

[0093] 2.4 M...

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PUM

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Abstract

The present invention relates to an application of a composition containing ginkgo terpene lactones in preparation of a medicament for preventing and / or treating venous thromboembolic diseases. The invention also relates to a composition containing the ginkgo terpene lactones and xaban family medicaments, and an application thereof in preparation of the medicament for preventing and / or treating the venous thromboembolic diseases. The composition containing the ginkgo terpene lactones and the composition containing the ginkgo terpene lactones and the xaban family medicaments are effective against formation of the venous thrombus (anticoagulation and improving blood composition) and treat related diseases involving venous thromboembolism, so that an application range of a compound of the ginkgo terpene lactones expands, and a new option, which has the characteristics of lower bleeding risk, suitable price, definite curative effect, safety and reliability, and convenient usage, is provided for treatment of venous thrombus.

Description

technical field [0001] The invention relates to the field of pharmacy, in particular to the use of a ginkgolide compound in the preparation of medicines for preventing and / or treating venous thromboembolic diseases; the invention also relates to a compound containing ginkgolide and sabans The composition of medicine, and its use in the preparation of medicine for preventing and / or treating venous thromboembolic diseases. Background technique [0002] As my country gradually enters an aging society, the incidence of cardiovascular and cerebrovascular diseases, deep vein thrombosis and other diseases related to thrombosis is increasing year by year, which has become the main factor threatening the health of middle-aged and elderly people in my country. [0003] Thrombosis refers specifically to the formation of blood clots in the lumen of the vascular system. The mechanism of thrombosis is very complex, and there are still many problems to be elucidated. The three-element hy...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/365A61K45/06A61P7/02
CPCA61K45/06A61K31/365A61K2300/00
Inventor 孙毅田阿娟李慧琴
Owner CHENGDU BAIYU PHARMA CO LTD
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