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Ordered collagen scaffold and applications of ordered collagen scaffold in preparation of spinal cord injury repair products

A collagen scaffold and spinal cord injury technology, applied in the field of biomedical materials, can solve problems such as unsatisfactory clinical effects, and achieve the effect of promoting growth and regeneration of spinal cord nerves

Active Publication Date: 2018-12-18
DUBU BIOSCIENCES
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Problems solved by technology

However, combined with microtubule stabilizing drugs to regulate the differentiation of neural stem cells into neurons, there is no literature report at home and abroad.
[0006] Studies have shown that the clinical effect of traditional intrathecal drug administration is not ideal. Therefore, it is urgent to find an ideal way to load small molecule drugs and maintain an effective concentration in the microenvironment of the spinal cord injury for a certain period of time.

Method used

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  • Ordered collagen scaffold and applications of ordered collagen scaffold in preparation of spinal cord injury repair products
  • Ordered collagen scaffold and applications of ordered collagen scaffold in preparation of spinal cord injury repair products
  • Ordered collagen scaffold and applications of ordered collagen scaffold in preparation of spinal cord injury repair products

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[0051] Another aspect of the embodiments of the present invention provides a method for preparing an ordered collagen scaffold, which includes:

[0052] Dissolve the collagen raw material in 0.2-1mol / L acetic acid and let it stand overnight at 2-8°C, mix well and then add 2-10mol / L lye to neutralize, and put the obtained uniform liquid into the molecular weight cut-off of 3000-5000 Dialyze with deionized water for 4 to 6 days in a dialysis bag, change the deionized water every 3 to 6 hours during the dialysis period, put the solution after dialysis into a mold with a diameter of 4 to 10 mm, and then place one end of the mold at -150 to At -80°C, an ordered collagen sponge cylinder scaffold was obtained;

[0053] Liposomes wrapped with anticancer drugs with microtubule stabilizing effect are added dropwise to the ordered collagen sponge cylindrical scaffold, and then incubated at 25-37° C. for 1-3 hours to obtain the ordered collagen scaffold.

[0054] Another aspect of the em...

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Abstract

The present invention discloses an ordered collagen scaffold and applications of the ordered collagen scaffold in preparation of spinal cord injury repair products, wherein the ordered collagen scaffold comprises an ordered collagen sponge cylinder scaffold, the ordered collagen sponge cylinder scaffold comprises a three-dimensional structure formed mainly by orderly arranging a plurality of porechannel structures, the ordered collagen sponge cylinder scaffold is doped with liposome, and the liposome encapsulates an anticancer drug having microtubule stabilizing effect. According to the present invention, the ordered collagen scaffold has the ordered pore channel structure so as to provide the contact induction effect for neurite growth; and importantly the sustained release of the anticancer drug having microtubule stabilizing effect in the liposome can alleviate the influence of myelin protein in the environment after the spinal cord injury so as to promote the differentiation of the transplanted neural stem cells into the neurons and promote the growth of the neurite, such that the regeneration of the injured spinal nerves and the repair of the motor function can be promoted.

Description

technical field [0001] The invention relates to an ordered collagen scaffold for repairing spinal cord injuries and a preparation method thereof, as well as its application in preparing products for repairing spinal cord injuries, belonging to the technical field of biomedical materials. Background technique [0002] Spinal cord injury is a common severe central nervous system injury in clinical practice, often causing permanent sensory and motor dysfunction below the level of injury, bringing great pain to patients and their families. Moreover, the treatment of spinal cord injuries remains a major challenge. [0003] Stem cell transplant therapy offers hope for repairing spinal cord injuries. Neural stem cells have the potential to self-renew and differentiate into neurons, astrocytes, and oligodendrocytes. The axon regeneration of differentiated neurons is expected to achieve synaptic connection with the body and promote nerve injury repair (Axonal growth and connectivit...

Claims

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Application Information

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IPC IPC(8): A61L27/24A61L27/54A61L27/56
CPCA61L27/24A61L27/54A61L27/56A61L2300/416A61L2300/626A61L2430/32
Inventor 戴建武李晓然
Owner DUBU BIOSCIENCES
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