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Metronidazole gargle and preparation method thereof

A metronidazole and gargle technology, applied to medical preparations containing active ingredients, pharmaceutical formulas, and medical preparations without active ingredients, etc., can solve the problems of short storage period and achieve stable properties and low microbial content Effect

Inactive Publication Date: 2018-12-21
山西天致药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing metronidazole gargles on the market have a short shelf life, only 1-2 years

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Metronidazole gargle, based on a prescription volume of 1200L, is prepared using the following raw materials and procedures:

[0026] A. Preparation of mint water: Mix 480 mL of mint oil, 480 mL of polysorbate 80, 14400 mL of ethanol and 10 L of purified water in a stainless steel container, stir for about 10 minutes until dissolved, and obtain mint water.

[0027] B. Preparation: Add 352L of purified water to the liquid mixing tank, put 6kg of metronidazole in the turnover container, add 2L of purified water to the turnover container, stir and pour it into the liquid mixing tank.

[0028] Put 2.4kg of sodium citrate, 0.48kg of ethylparaben and 1.8kg of sodium saccharin in a turnover container, add 1.5L of purified water and stir, then pour it into a liquid mixing tank.

[0029] After continuing to add 580L of purified water into the liquid mixing tank, start stirring and heating, and boil until all the solids are dissolved.

[0030] Open the cooling water control valv...

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Abstract

The invention belongs to the technical field of nitro-compound containing medicine preparations and in particular relates to metronidazole gargle which comprises the following components: metronidazole, sodium citrate, ethylparaben, saccharin sodium, peppermint water and water. The metronidazole gargle is a colorless or slight yellow clear liquid which is bitter in taste with slight sweetness, hasspecial fragrance, has a pH value of 5.5-8.5, has a minimum fill which is not less than 93% of a labeled amount, has an average weight which is not less than the labeled amount, is low in microorganism content and stable in property, and has a preservation time of at least two years.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations containing nitro compounds, and in particular relates to a metronidazole gargle and a preparation method thereof. Background technique [0002] Metronidazole is mainly used to treat or prevent systemic or local infections caused by the above-mentioned anaerobic bacteria, such as anaerobic bacterial infections in the abdominal cavity, digestive tract, female reproductive system, lower respiratory tract, skin and soft tissues, bones and joints, etc. , endocarditis, meningeal infection, and colitis caused by antibiotics are also effective. Tetanus is often treated with tetanus antitoxin (TAT). It can also be used for oral anaerobic infection. [0003] At present, metronidazole preparations on the market are mainly metronidazole gargles. However, the existing metronidazole gargles on the market have a short shelf life, only 1-2 years. Contents of the invention [0004] In vie...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K31/4164A61K47/46A61P31/02A61P31/10A61P1/02
CPCA61K9/006A61K31/4164A61K47/46A61P1/02A61P31/02A61P31/10
Inventor 胡华东
Owner 山西天致药业有限公司
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