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Earthworm syrup nanosilver hydrogel patch and preparation method thereof

A technology of hydrogel patch and nano-silver sol is applied in the directions of anti-inflammatory agents, pharmaceutical formulations, non-central analgesics, etc., which can solve the problems of unsuitable storage of Dilong syrup, inability to act as antibacterial and anti-inflammatory, and difficult quality control. , to achieve efficient and safe drug resistance, help wound healing, and not easy to drug resistance.

Active Publication Date: 2018-12-21
SICHUAN AGRI UNIV
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  • Description
  • Claims
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Problems solved by technology

[0009] In view of this, the present invention aims at the fact that the traditional earthworm syrup is not suitable for storage, it is easy to deteriorate, the quality is not easy to control, it is inconvenient to use, it is easy to contaminate clothes, and it cannot play the role of antibacterial and anti-inflammatory, and nano silver cannot directly act on burns and sores. problem, a kind of earthworm syrup nano-silver hydrogel patch and its preparation method are provided

Method used

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  • Earthworm syrup nanosilver hydrogel patch and preparation method thereof
  • Earthworm syrup nanosilver hydrogel patch and preparation method thereof
  • Earthworm syrup nanosilver hydrogel patch and preparation method thereof

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preparation example Construction

[0032] The invention discloses a preparation method of earthworm syrup nano-silver hydrogel patch, which comprises the following steps:

[0033] Step 1. Prepare earthworm syrup: soak earthworm in clean water to wash the soil, take it out and put it on absorbent paper to absorb the water, and obtain pretreated earthworm, mix the pretreated earthworm with sugar, and , the mass ratio of pretreated earthworm to white sugar is 1:0.6-1:1.6, and after standing for 1.5-2.5h, earthworm will gradually precipitate body fluid and shrink; the mixture is centrifuged and filtered for 2-3 times, and the leachate is taken That is earthworm syrup;

[0034] Step 2. Preparation of nano-silver: put nano-silver in distilled water, and ultrasonically treat it for 5-15 minutes to obtain nano-silver sol; wherein, the mass-volume ratio (g / L) of nano-silver to distilled water is 1:20-8:20 ;

[0035] Step 3, preparation of earthworm syrup nano-silver hydrogel patch: select sodium polyacrylate as cross-...

Embodiment 1

[0042] (1) Preparation of earthworm syrup: soak earthworm in clean water to wash the soil, take it out and put it on absorbent paper to absorb the water, weigh 10g and put it into a 50mL clean beaker, add 5g of sugar, let stand, earthworm is ready Gradually precipitate body fluid and shrink. After 2 hours, the mixture was centrifuged and filtered 2-3 times, and the leachate was obtained as earthworm syrup.

[0043] (2) Preparation of nano-silver: take nano-silver and place it in distilled water, and ultrasonically treat it for 10 minutes to obtain nano-silver sol; wherein, the mass-volume ratio (g / L) of nano-silver to distilled water is 4:20;

[0044] (3) Preparation of hydrogel patch: select sodium polyacrylate as cross-linking skeleton, aluminum glycolate as cross-linking agent, glycerin as humectant, EDTA and tartaric acid as cross-linking regulator, carbomer, CMC-Na, PVPk30 Propylene Glycol is a penetration enhancer. Weigh 9.6g glycerin and 2g ethylene glycol in a clean ...

Embodiment 2

[0046] Step 1. Prepare earthworm syrup: soak earthworm in clean water to wash the soil, take it out and put it on absorbent paper to absorb the water, and obtain pretreated earthworm, mix the pretreated earthworm with sugar, and , the mass ratio of the pretreated earthworm to white sugar is 1:0.6, and after standing for 2.5 hours, the earthworm gradually precipitates body fluid and shrinks; the mixture is centrifuged and filtered for 2-3 times, and the extract is taken as earthworm syrup;

[0047] Step 2, preparing nano-silver: take nano-silver and place it in distilled water, and ultrasonically treat it for 15 minutes to obtain nano-silver sol; wherein, the mass-volume ratio (g / L) of nano-silver to distilled water is 1:20;

[0048] Step 3, preparation of earthworm syrup nano-silver hydrogel patch: select sodium polyacrylate as cross-linking skeleton, aluminum glycolate as cross-linking agent, glycerin as humectant, EDTA and tartaric acid as cross-linking regulator, carbomer, ...

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Abstract

The invention discloses an earthworm syrup nanosilver hydrogel patch and a preparation method thereof. The preparation method comprises the following steps: preparing earthworm syrup; preparing nanosilver sol; preparing the earthworm syrup nanosilver hydrogel patch. According to the patch disclosed by the invention, the earthworm syrup is mixed with an antibacterial material, namely nanosilver, and 'alliance between giants' is achieved, so that the patch is efficient and safe and not liable to cause drug resistance; a novel hydrogel patch is prepared, the patch is convenient and comfortable touse, free of clothes staining and high in medicine utilization rate, meanwhile, a continuous low-temperature function is achieved because of a moisturizing characteristic of the patch, then wound healing can be assisted, and the medicine effect and the quality of the product can be improved.

Description

technical field [0001] The invention belongs to the technical field of drug research and development, and in particular relates to a nano-silver hydrogel patch for earthworm syrup and a preparation method thereof. Background technique [0002] Burns and scalds are accidental injuries that we often encounter in our daily life. The causes of burns and scalds are different, but the first principles of treating burns and scalds are all the same. Generally, it is necessary to clear away heat and solve problems such as wound infection, pain and healing. At present, there are many kinds of medicines for burns and scalds, mainly including traditional Chinese medicines and western medicines. Traditional Chinese medicines take effect slowly and are relatively complicated to prepare. Western medicines are quick in efficacy but prone to drug resistance. The dosage forms are mostly ointments, oils, etc., which are very easy to contaminate clothes , Inconvenient to use. [0003] Dilong i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/62A61K9/70A61P31/04A61P29/00A61P17/02A61K33/38
CPCA61K9/7023A61K33/38A61K35/62A61K47/38A61P17/02A61P29/00A61P31/04A61K2300/00
Inventor 李丽霞卢先云李芳龙冯鑫陈容殷中琼邹元锋宋旭梁晓霞
Owner SICHUAN AGRI UNIV
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