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Detection method for borneol contents in concentrated pill for promoting coronary circulation

A detection method, the technology of Huoxin Pills, which is applied to measuring devices, instruments, scientific instruments, etc., can solve the problems of not being able to know the content of borneol, and cannot fully control the quality of Huoxin Pills, so as to achieve comprehensive quality control, strong specificity, reproducible results

Inactive Publication Date: 2018-12-21
GUANGZHOU RUIKANG BIOLOGICAL PHARMA
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  • Claims
  • Application Information

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Problems solved by technology

[0004] In the original standard for quality inspection of concentrated Huoxin Pills (recorded in the eighteenth volume of Ministry-promulgated Standards for Traditional Chinese Medicine Prescriptions, standard number: WS 3 -B-3452-98), there is only TLC identification of borneol but no content identification of borneol. We can only know whether borneol is contained in Huoxin Pills but not the content of borneol. It is impossible to fully control the quality of Huoxin Pills. Therefore, it is necessary to provide A method for detecting borneol content in concentrated Huoxin pills

Method used

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  • Detection method for borneol contents in concentrated pill for promoting coronary circulation
  • Detection method for borneol contents in concentrated pill for promoting coronary circulation
  • Detection method for borneol contents in concentrated pill for promoting coronary circulation

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Embodiment 1

[0023] Chromatographic conditions and system suitability test: Polyethylene glycol 20000 (PEG-20M) capillary column with a column length of 30m, an inner diameter of 0.25mm, and a film thickness of 0.25μm; After 11 minutes, the temperature was raised to 200°C at a rate of 30°C per minute and kept for 9 minutes. The number of theoretical plates should not be less than 2000 based on the borneol peak.

[0024] Take the appropriate amount of isoborneol reference substance and borneol reference substance, accurately weighed, add absolute ethanol to make a mixed solution containing 0.08mg of isoborneol and 0.1mg of borneol per 1ml, as the reference substance solution; take the above-mentioned 5 batches respectively The test product, grind finely, each take about 0.2g, accurately weighed, respectively placed in a conical flask with a stopper, accurately add 20ml of absolute ethanol, weighed, ultrasonic treatment with power 350W, frequency 37kHz for 20 minutes, put Cool, weigh again,...

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Abstract

The invention belongs to the field of medicine detection, discloses a detection method for borneol contents in a concentrated pill for promoting coronary circulation, and performs an important guidance meaning for the quality control of the concentrated pill for promoting coronary circulation. The detection method for borneol contents in the concentrated pill for promoting the coronary circulationcomprises the following specific steps that: 1: taking a proper quantity of isoborneol reference substances and camphol reference substances, carrying out precise weighing, and adding absolute ethylalcohol to prepare reference substance solution; 2: taking a sample for testing, carrying out porphyrization and precise weighing, adding absolute ethyl alcohol, weighing weight, carrying out ultrasonic treatment, weighing weight again, supplementing lost weight by the absolute ethyl alcohol, evenly shaking, filtering, taking subsequent filtrate, and obtaining the solution of the sample for testing; and 3: precisely adsorbing 1[mu]l of reference substance solution and 1[mu]l of solution of the sample for testing, injecting into a gas chromatograph, and carrying out measurement. 1g of concentrated pill for promoting coronary circulation contains at least 13.5mg of borneol by metering by the total amount of isoborneol (C10H18O) and camphol (C10H8O).

Description

technical field [0001] The invention belongs to the field of drug detection, in particular to a method for detecting the content of borneol in concentrated Huoxin pills. Background technique [0002] Borneol, also known as sliced ​​brain, orange slice, moxa slice, dipteroxiang, plum blossom borneol, jiebuluoxiang, plum blossom brain, borneol, plum ice, etc. Branches and leaves are obtained by steam distillation and recrystallization. Turpentine is also available through a series of chemical processes. Borneol has the functions of promoting drug absorption, antibacterial, anti-inflammatory and pain relief, reducing swelling and pain, clearing away heat and fire, and can be used for closed syndrome and coma, red eyes and swelling pain, sore throat and sores, swelling and pain after ulceration, etc. . [0003] Although borneol has high medicinal value and can treat many common human diseases, it is a drug with relatively serious adverse reactions. If it is taken in excess, i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02
CPCG01N30/02
Inventor 上官康
Owner GUANGZHOU RUIKANG BIOLOGICAL PHARMA
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