Methods of Improving the Appearance of Periorbital Dyspigmentation
A technology for abnormal pigmentation and appearance, which can be used in pharmaceutical formulations, skin care preparations, medical preparations containing active ingredients, etc., and can solve problems such as periorbital pigmentation abnormalities and types that do not have a generally accepted definition
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Examples
Embodiment 1
[0077] Embodiment 1-formulation embodiment
[0078] Table 2 shows five exemplary oil-in-water emulsion cosmetic compositions for use in the method according to the invention. Compositions A to E can be prepared as follows. In a suitable vessel the aqueous phase ingredients are combined and heated to 75°C. In a separate suitable vessel, the oil phase ingredients were combined and heated to 75°C. Add the oil phase to the water phase and grind the resulting emulsion (e.g. with TEKMAR TM T-25 or equivalent). Add the thickener to the emulsion and cool to 45°C while stirring. At 45°C, the remaining ingredients were added. The product was cooled to 30°C with stirring and poured into suitable containers.
[0079] Table 2
[0080]
[0081]
[0082] 1 Palmitoyl-lysine-threonine-threonine-lysine-serine was purchased from Sederma (France)
[0083] 2 Titanium dioxide-coated mica, purchased from Kobo Products Inc.
[0084] 3 Tapioca starch and polymethylsilsesquioxane ...
Embodiment 2
[0114] Example 2: In vivo studies (VPS, blood perfusion and imaging) .
[0115] This example demonstrates the ability of the method of the invention to improve the appearance of Type II and Type III periorbital pigmentary variations. Twenty-five Caucasian female subjects aged 20 to 60 were recruited in a nine-week faceted round-robin design study to evaluate the ability of faba bean extract to improve the appearance of type II and type III periorbital pigmentary variations. The oil-in-water emulsion of Example R from Table 5 was evaluated in this study.
[0116] During the study, the sub-eye portion of the periorbital area on the left side of the face of the test subjects (i.e. Figure 4A The shaded area 400 in ) and the undereye portion of the periorbital region on the right side of the test subject's face were treated with a vehicle control (ie, the same composition as the test composition, except without the faba bean extract). Test subjects were instructed to use the c...
Embodiment 3
[0136] Example 3: In Vitro Studies (B16-Melanin Assay)
[0137] This example demonstrates that the broad bean extract has no ability to inhibit melanin synthesis. Excess melanin is believed to be a major contributor to the appearance of type I periorbital dyspigmentation, but not type II. Therefore, treatment of type I periorbital dyspigmentation with faba bean extract should not provide any improvement in its appearance, as evidenced by the lack of melanin-suppressive activity in conventional B16 assays. This is important because it shows that a "one size fits all" approach may not be the best way to treat all types of periorbital melanoma. For example, a composition utilizing a broad bean extract may not improve the appearance of type I periorbital dyspigmentation.
[0138] In this example, a commercially available B16-F1 mouse melanoma cell line from the American Tissue Culture Collection (Virginia, USA) was used in a conventional melanin synthesis inhibition assay. Th...
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Abstract
Description
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Application Information
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