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Index of local severity of atopic dermatitis in skin and therapeutic effect thereon

A technology for atopic dermatitis and skin, applied in health index calculation, microbiological measurement/inspection, computer-aided medical procedures, etc., can solve the problems of inconsistency in size and inability to judge the prognosis of the rising degree of numerical value, etc.

Inactive Publication Date: 2018-12-21
SHISEIDO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, α-fetoprotein (AFP) as a tumor marker is a diagnostic marker, but its value does not correspond to the size of the tumor. In addition, the degree of increase in the value cannot be used to judge the prognosis

Method used

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  • Index of local severity of atopic dermatitis in skin and therapeutic effect thereon
  • Index of local severity of atopic dermatitis in skin and therapeutic effect thereon
  • Index of local severity of atopic dermatitis in skin and therapeutic effect thereon

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0151] 1. Evaluation and observation items

[0152] (1) What the doctor sees on the skin

[0153] At each site, observe (A) erythema, (B) infiltration (oozing), (C) papule (D) scratch (excoriation), (E) lichenification (lichenification), (F ) dryness / desquamation (xerosis), (G) itching (itch), record the degree of severity in the medical record card.

[0154] The evaluation criteria were 0: absence (absence), 1: mild (mild), 2: moderate (moderate), and 3: severe (severe). The healthy part where the stratum corneum was collected, the rash part, and the rash-free part were recorded in the whole-body map.

[0155] (2) Collection and determination of cuticle tape

[0156] The stratum corneum of the test site was collected using Cello Tape (registered trademark) (2 cm x 6 cm). The obtained stratum corneum sample was immersed in a protein extraction solution (0.1M Tris-HCl (pH 8.0), 0.14M NaCl, 0.1% Tween 20), and extracted with a Bioraptor. Centrifugation was performed and the...

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Abstract

Provided is an objective and convenient index for judging full recovery from atopic dermatitis and severity thereof. The present invention provides a diagnosis assisting method for determining a treatment policy for an atopic dermatitis subject under the treatment, said method comprising: measuring the expression value of SCCA-1 in skin horny cells of the subject; i) when the SCCA-1 expression value is not statistically significantly higher than the level of those who do not suffer from atopic dermatitis, then determining that the continuation of the treatment for the disease becomes unnecessary thanks to the treatment; and, in the case where the continuation of the treatment is determined as still necessary, ii) ranking the severity of atopic dermatitis of the subject using the SCCA-1 expression value as an index and determining an adequate treatment method for atopic dermatitis to be given to the subject depending on the rank.

Description

technical field [0001] The present invention provides a method for non-invasively evaluating local pathological conditions of atopic dermatitis using Squamous Cell Carcinoma Antigen 1 (hereinafter referred to as "SCCA-1") in skin stratum corneum cells as an index. Background technique [0002] Atopic dermatitis is one of the most common skin diseases and occurs frequently mainly in infancy, but in recent years, the number of patients after puberty has increased. Atopic dermatitis is a disease characterized by repeated exacerbations and remissions, mainly caused by eczema with itching. The pathogenesis of atopic dermatitis is still unclear, but it is considered to be mainly caused by genetic constitution plus various environmental factors. The so-called genetic predisposition indicates whether 1) whether there is a family history or past history of bronchial asthma, allergic rhinitis, conjunctivitis, atopic dermatitis, etc., or 2) a constitution prone to producing IgE antibod...

Claims

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Application Information

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IPC IPC(8): G01N33/53C12Q1/04G01N33/543
CPCG01N33/6881G01N2800/202G01N2333/8121G01N2800/52G01N33/53G01N2800/56G01N33/543G16H50/30G06F17/18
Inventor 田中千华水本智惠子小野寺智子相场节也菊地克子山崎研志小泽麻纪
Owner SHISEIDO CO LTD