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Preparation method and application of a dual-regulated supramolecular assembly that inhibits tumor invasion and spread

A supramolecular assembly and supramolecular technology, which is applied in the direction of antineoplastic drugs, non-active ingredients of polymer compounds, and drug combinations, can solve the problems of high cancer mortality, hindering anti-metastasis therapy, and insufficient understanding of pathogenesis. The preparation method is simple, the application prospect is wide, and the effect of inhibiting tumor cell invasion and diffusion

Active Publication Date: 2022-01-28
NANKAI UNIV
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  • Description
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Problems solved by technology

[0002] Despite great advances in drug therapy and practical techniques for early-stage primary tumors, invasiveness and metastases remain the most mysterious aspects and thorniest issues in cancer therapy
According to statistics, due to the inoperable nature of surgical operations and the lack of therapeutic drugs to prevent the spread of cancer cells clinically, the cancer-related mortality caused by the metastasis of cancer cells to other sites is as high as 90%
In addition, our insufficient understanding of the pathogenesis of tumor cell invasion and metastasis also hinders the development of effective anti-metastatic therapies

Method used

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  • Preparation method and application of a dual-regulated supramolecular assembly that inhibits tumor invasion and spread
  • Preparation method and application of a dual-regulated supramolecular assembly that inhibits tumor invasion and spread
  • Preparation method and application of a dual-regulated supramolecular assembly that inhibits tumor invasion and spread

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Embodiment

[0038] A dual-regulated supramolecular assembly that inhibits tumor invasion and spread. Its construction unit is based on β-cyclodextrin-modified hyaluronic acid and octapeptide-modified magnetic nanoparticles. Nanosupramolecular fiber aggregates constructed by interaction. Among them, the hyaluronic acid modified by β-cyclodextrin is obtained by amide condensation of mono-6-deoxy-6-ethylenediamino-β-cyclodextrin and sodium hyaluronate, and the magnetic nanoparticles modified by octapeptide are silanized Fe 3 o 4 Magnetic nanoparticles were covalently linked to fluorescein isothiocyanate-labeled mitochondria-targeting octapeptide. The structure of the nanofiber aggregate building unit is shown in the appendix Figure 9 .

[0039] A method for preparing a dual-regulated supramolecular assembly that inhibits tumor invasion and spread, the steps are as follows:

[0040] 1) Synthesis of β-cyclodextrin-modified hyaluronic acid (HACD)

[0041] 1-(3-Dimethylaminopropyl)-3-ethy...

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Abstract

A preparation method and application of a double-regulated supramolecular assembly that inhibits tumor invasion and spread. Nano-supramolecular fiber aggregates constructed by supramolecular host-guest interactions. The advantages of the present invention are: the supramolecular assembly is oriented and aggregated under the induction of the geomagnetic field or a weak magnetic field, and can be light-controlled to induce the aggregation of the supramolecular assembly; on the other hand, the supramolecular assembly can specifically attract cancer cells, and the assembly can cause damage to mitochondria; the preparation method of the supramolecular assembly with dual regulation of magnetic field and light is simple, easy to implement and low in raw material cost, making it widely used in the field of tumor treatment, especially in Active inhibition of tumor cell invasion and spread has broad application prospects.

Description

technical field [0001] The invention relates to a technology for inhibiting tumor invasion and diffusion, in particular to a preparation method and application of a supramolecular assembly capable of inhibiting tumor invasion and diffusion with dual regulation of magnetic field and light. Background technique [0002] Despite great advances in drug therapy and practical techniques for early primary tumors, invasiveness and metastasis remain the most mysterious aspects and thorniest issues in cancer treatment. According to statistics, due to the inoperable nature of surgery and the lack of therapeutic drugs to prevent the spread of cancer cells clinically, the cancer-related mortality caused by the metastasis of cancer cells to other sites is as high as 90%. In addition, our insufficient understanding of the pathogenesis of tumor cell invasion and metastasis also hinders the development of effective anti-metastatic therapies. Therefore, it is imperative to establish new and ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/69A61K47/42A61K47/02A61K47/40A61P35/00
CPCA61K47/02A61K47/40A61K47/42A61K47/6951A61P35/00
Inventor 刘育喻其林张瀛溟刘耀华许璕
Owner NANKAI UNIV
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