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Prebiotic-fecal bacterium liquid composite liquid for treating irritable bowel syndrome

A technology for irritable bowel syndrome and probiotics liquid, applied in the medical field, can solve the problems of non-disability and long-term use, and achieve the effects of improving clinical efficacy, fast intestinal flora reconstruction, and promoting intestinal flora reconstruction.

Inactive Publication Date: 2019-01-04
南京益恒寿生命科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As we all know, probiotics play an important role in improving intestinal health, but they are not endogenous flora in the human intestinal tract, and they need to be taken for a long time to play a role

Method used

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  • Prebiotic-fecal bacterium liquid composite liquid for treating irritable bowel syndrome
  • Prebiotic-fecal bacterium liquid composite liquid for treating irritable bowel syndrome

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] The preparation of probiotics and fecal bacteria liquid composite liquid comprises the following steps:

[0016] (1) Preparation of standard fecal bacteria liquid: 1 qualified donor was screened, 50 g of feces were aseptically collected, homogenized, filtered through gauze and centrifuged, and the supernatant was discarded to obtain fecal bacteria sludge.

[0017] (2) Compound probiotic liquid preparation: Measure 200ml of sterile normal saline into a sterile beaker, add Lactobacillus helveticus 1×10 10 / CFU, Bifidobacterium longum 0.5×10 9 / CFU, mix well.

[0018] (3) Preparation of probiotics-fecal bacteria liquid compound liquid: mix 200ml compound probiotic liquid and fecal bacteria slurry sediment evenly

Embodiment 2

[0019] Example 2 Study on the Treatment of Diarrhea Predominant Irritable Bowel Syndrome by the Compound Liquid of Probiotics and Fecal Bacteria of the Present Invention

[0020] (1) Patient screening: Patients with combined IBS Rome II in 1999, aged 20-60 years, male or female, did not receive microecological and fecal microbiota transplantation within two weeks. All patients signed informed consent, and a total of 90 patients were selected. Among them, 30 cases received fecal bacteria transplantation treatment, probiotics treatment and probiotics-fecal bacteria transplantation combined treatment.

[0021] (2) Treatment plan: each patient in the fecal microbiota transplantation treatment group received a standard fecal microbiota solution equivalent to 50 g of feces, which was transported to the colon through a colonoscope, and treated once; each patient in the probiotic treatment group received Lactobacillus helveticus 1×10 10 / CFU, Bifidobacterium longum 0.5×10 9 One caps...

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PUM

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Abstract

The invention discloses a compound for treating irritable bowel syndrome through transplanting of prebiotics and fecal bacteria. The preparation method comprises the following steps: (1) preparing standard fecal bacterium liquid; (2) preparing compound prebiotic liquid; and (3) preparing prebiotic-fecal bacterium liquid composite liquid. Clinical research proves that the effect for treating the irritable bowel syndrome by the prebiotic-fecal bacterium liquid composite liquid is more excellent than that of single use of prebiotic or fecal bacteri transplanting.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to the preparation of a probiotic-fecal liquid complex liquid for treating irritable bowel syndrome. Background technique [0002] Fecal microbiota transplantation (FMT) began at least in the 4th century AD in the history of world medicine, but it has not achieved unprecedented rapid development until recent years. In 2013, FMT was written into the American Medical Guidelines for the first time for the treatment of recurrent Clostridium difficile infection (CDI). At the same time, it has also achieved good clinical efficacy in the treatment of inflammatory bowel disease, irritable bowel syndrome, metabolic syndrome and other intestinal and intestinal diseases at home and abroad. As we all know, probiotics play an important role in improving intestinal health, but they are not endogenous flora in the human intestinal tract and need to be taken for a long time to play a role. This ...

Claims

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Application Information

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IPC IPC(8): A61K35/747A61P1/00A61K35/745A61K35/741
CPCA61K35/741A61K35/745A61K35/747A61P1/00A61K2300/00
Inventor 刘志峰种法政郑必霞张昊张钧寿
Owner 南京益恒寿生命科技有限公司
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