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Antibacterial device to be implanted in vivo

A technology for implanting devices and implants, applied in prosthesis, internal bone synthesis, medical science, etc., can solve the problem of difficulty in preventing the growth of microorganisms, and achieve the effect of reducing the burden

Active Publication Date: 2019-01-04
美敦力索发摩尔丹耐克有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Difficult to prevent microbial growth if implanted device becomes colonized by microorganisms
In order to prevent the growth and infection of microorganisms in the body, it is necessary to perform surgery to remove the implanted device to replace it with a new implanted device, which imposes a huge burden on the patient

Method used

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  • Antibacterial device to be implanted in vivo
  • Antibacterial device to be implanted in vivo
  • Antibacterial device to be implanted in vivo

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0058] (Preparation of samples)

[0059] Commercially available biocompatible titanium alloy (titanium content: 88 to 91 mass%) and commercially available biocompatible cobalt-chromium alloy (cobalt content: 58 to 69 mass%, chromium content: 26 to 30 mass%) 3 mm thick coin-shaped samples were processed into various areas shown in Table 1 (only the titanium alloy of sample No. short circuit. As comparative samples, a flat polyethylene sample of 1 mm thickness (control), a coin-shaped sample of 3 mm thickness made of cobalt-chromium alloy (comparison 1), and a coin-shaped sample of 3 mm thickness made of titanium alloy were similarly prepared (compare 2).

[0060] [Table 1]

[0061] Table 1 Sample Conditions

[0062]

[0063]

[0064] *Area ratio = surface area of ​​titanium alloy / surface area of ​​cobalt-chromium alloy

[0065] (antimicrobial properties test)

[0066] Antimicrobial properties are evaluated with reference to JIS Z 2801: Antimicrobial Products - Antim...

example 2

[0075] (Preparation of samples)

[0076] An implant device made of a titanium alloy and a cobalt-chromium alloy (the area ratio of the titanium alloy to the cobalt-chromium alloy was set to 0.89) was prepared (implant device 1). As a comparative example, an implant device (implant device 2 ) made only of a titanium alloy having exactly the same shape was similarly prepared.

[0077] [table 3]

[0078] Table 3 Composition of the implanted device

[0079]

[0080] *Area ratio = surface area of ​​member made of titanium alloy / surface area of ​​member made of cobalt-chromium alloy

[0081] (antimicrobial properties test)

[0082] Each implant was placed in a polypropylene tube and immersed in 1 ml of Staphylococcus aureus (NBRC 12732) suspended in nutrient broth (1 / 100). After culturing at 35°C for 24 hours, the medium was collected. The collected medium was serially diluted in 10-fold dilution series, and cultured at 35° C. for 24 hours using an agar plate culture method,...

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PUM

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Abstract

Provided is a device to be implanted in vivo, which can exhibit antibacterial activity simply by being implanted in vivo, in order to reduce patient load. This device to be implanted in vivo comprisesa first material and a second material, wherein at least the surface of the first material includes an antibacterial metal, at least the surface of the second material is more precious than the firstmaterial, when used implanted in vivo an electrical circuit is formed between the first material and the second material, antibacterial metal ions are eluted from the first material in the presence of an electrolyte, and antibacterial action is exhibited on the surface and / or in the proximity of the surface of the first material.

Description

technical field [0001] The present invention relates to implant devices, and more particularly to implant devices that achieve antimicrobial properties when used implanted in the body. Background technique [0002] Various instruments such as cages, wires, plates, screws, rods, connectors, crosslinks, hooks, fixation screws, artificial vertebral bodies, and artificial intervertebral discs are used as orthopedic implant devices. When these devices are used implanted in the body, they may become contaminated with microorganisms. If an implanted device becomes colonized by microorganisms, it is difficult to prevent the growth of microorganisms. In order to prevent the growth and infection of microorganisms in the body, it is necessary to surgically remove the implanted device to replace it with a new implanted device, which imposes a great burden on patients. It would be desirable to provide antimicrobial implanted devices. [0003] As a technique for imparting antimicrobial...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B17/80A61L27/04A61L27/42
CPCA61B17/80A61L27/06A61L27/306A61L27/50A61L27/54A61L31/028A61L31/088A61L31/14A61L31/16A61L2300/102A61L2300/404A61L2300/602A61L27/56A61L31/146
Inventor 杉野笃史福崎智司
Owner 美敦力索发摩尔丹耐克有限公司
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