Dynamic real-time evaluation equipment for irreversible electroporation tissue ablation

A technology for tissue ablation and evaluation equipment, applied in the direction of heating surgical instruments, etc., can solve the problem that tumors are difficult to achieve real-time dynamic monitoring of curative effect during treatment, and achieve the effect of avoiding signal instability and reflecting the limited ablation area

Inactive Publication Date: 2019-01-08
CHONGQING UNIV
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Problems solved by technology

[0007] The purpose of the present invention is to provide a dynamic and real-time evaluation device for irreversible electroporation tissue ablation effect, so as to solve the problem that the curren

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  • Dynamic real-time evaluation equipment for irreversible electroporation tissue ablation
  • Dynamic real-time evaluation equipment for irreversible electroporation tissue ablation
  • Dynamic real-time evaluation equipment for irreversible electroporation tissue ablation

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Embodiment Construction

[0050] like figure 1 A dynamic and real-time evaluation device for irreversible electroporation tissue ablation effect shown, including a test pulse generation unit, a control unit, an electrode array, an output switching unit, a signal acquisition unit, a data processing unit, a user interface and a power supply for the device power supply.

[0051] Each unit is described in detail below:

[0052] The test pulse generating unit is used for generating test pulse signals, and by applying the test pulse signals before and after the high-voltage pulse treatment of the biological tissue, it is used to obtain the initial state of the biological tissue, the electrical properties during and after the high-pulse treatment. Wherein, the pulse width of the test pulse signal is at least a pulse width that can stabilize the response current, and its specific range may vary depending on the tissue. The pulse width of ≥10 μs can basically meet the requirements, but in order not to change t...

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Abstract

The invention discloses dynamic real-time evaluation equipment for irreversible electroporation tissue ablation, which utilizes an electrode in an irreversible electroporation tumor treatment primarypulse application process to detect tissue impedance spectrum changes before and after pulse treatment. As that instability of the impedance spectrum signal measure by the applied pulse electrode andthe problem of reflect the limited ablation area are effectively avoided, the relationship between the impedance spectrum measured by different electrode pairs and the actual ablation size is established aft subsequent data processing according to the impedance spectrum variation measured by different electrode pairs. At the same time, the change of tissue electrical properties was obtained by applying small signal test pulse during the treatment, and the mathematical model was established to judge the tissue ablation condition. At that same time, the invention can combine the advantage of thesweep frequency method and the test pulse method respectively, and solve the important problem of dynamic monitoring of curative effect in the treatment process of ablation effect aft irreversible electroporation pulse treatment and immediate evaluation of curative effect after treatment.

Description

technical field [0001] The invention relates to a dynamic and real-time evaluation device for irreversible electroporation tissue ablation effect. Background technique [0002] Cancer is a major disease that endangers human health. The traditional therapy of tumors and the newly developed thermal ablation physical therapy characterized by minimally invasive ablation have certain limitations in their clinical application due to the limitations of indications, contraindications, side effects of treatment, and heat depression. In recent years, with the continuous development of pulsed bioelectricity, electric field pulses have attracted the attention of researchers for their non-thermal and minimally invasive biomedical effects, and the irreversible electroporation treatment of tumors is fast, controllable, visible, and The advantages and characteristics of selectivity and non-thermal mechanism have attracted widespread attention of researchers in the field of bioelectricity a...

Claims

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Application Information

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IPC IPC(8): A61B18/12
CPCA61B18/12
Inventor 姚陈果董守龙赵亚军刘红梅马剑豪廖瑞金
Owner CHONGQING UNIV
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