Novel rare earth nano bimodal developer, preparation method thereof and application thereof

A dual-modal imaging agent and imaging agent technology, applied in the field of imaging medicine, can solve the problems of inability to perform dual-modal imaging and no therapeutic effect, and achieve better imaging effects, shorten relaxation time, and strong The effect of paramagnetic interaction

Active Publication Date: 2019-01-11
汪建华
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, currently commonly used CT or MRI contrast agents are usually not capable of bimodal imaging and have no therapeutic effect

Method used

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  • Novel rare earth nano bimodal developer, preparation method thereof and application thereof
  • Novel rare earth nano bimodal developer, preparation method thereof and application thereof
  • Novel rare earth nano bimodal developer, preparation method thereof and application thereof

Examples

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Embodiment 1

[0033] A novel rare earth nano dual-mode imaging agent, the imaging agent is NaHoF 4 @CeO 2 Nanoparticles.

[0034] A preparation method of a novel rare earth nanometer dual-mode imaging agent, the main experimental instruments and experimental materials in the preparation method include:

[0035] Holmium chloride hexahydrate (HoCl 3 ·6H 2 O, >99.99%), octadecene (OED, 90%), ammonium fluoride (NH 4 F, >99.99%), cerium nitrite hexahydrate (Ce(NO 3 ) 3 ·6H 2 O, >99.99%) and methoxypolyethanol (DSPE-mPEG5000, >99%), purchased from Promibio (Shanghai, China);

[0036] Human aortic endothelial cells (HAEC), human pancreatic cancer cells (Panc-1), provided by Shanghai Cancer Institute, Chinese Academy of Sciences;

[0037] 256-slice iCT imaging instrument, produced by Philips of the Netherlands;

[0038] NIUMAG 0.5T MRI small animal imaging system, produced by Shanghai Niumai Company in China;

[0039] Varian 23EX linear accelerator, produced by Varian Corporation of the U...

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Abstract

The invention discloses a novel rare earth nanometer bimodal developer, and a preparation method thereof and an application thereof. The novel rare earth nanometer bimodal developer is NaHoF4@CeO2 nanoparticles, and the preparation of the developer comprises the following steps: 1) preparation of NaHoF4 nanoparticles, 2) preparation of CeO2 nanoparticles, 3) adding nanometer CeO2 into NaHoF4 to obtain NaHoF4@CeO2 nanometer particles, the imaging agent is used in CT and MRI bimodal imaging. Physical and chemical characterization and toxicity test showed that the nanoparticles had good biological safety. In vitro experiment showed that the nanoparticles had good CT and MRI bimodal imaging effect, and had radiotherapy sensitization effect on pancreatic cancer cells.

Description

technical field [0001] The invention relates to the technical field of imaging medicine, in particular to a novel rare earth nanometer dual-mode imaging agent and its preparation method and application. Background technique [0002] In recent years, the development of multimodal imaging and imaging agents for diagnosis and treatment has become a research hotspot in the field of molecular imaging. CT (Computed Tomography) and MRI (Magnetic Resonance Imaging) have complementary advantages and are the most commonly used clinical tumor imaging methods. CT and MRI dual-modal imaging contrast agents can improve the detection rate and diagnostic accuracy of diseases, help to more accurately outline tumor boundaries, and provide accurate positioning for further radiotherapy. Currently, CT and MRI contrast agents commonly used in clinical practice cannot well meet the needs of dual-modality imaging. [0003] Some scholars conduct research on contrast agents for CT and MRI dual-moda...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/04A61K49/18A61K33/00A61P35/00B82Y5/00B82Y15/00
CPCA61K33/00A61K49/0002A61K49/04A61K49/183A61P35/00B82Y5/00B82Y15/00
Inventor 汪建华任志豪王思齐
Owner 汪建华
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