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HER2-targeted phase-change PLGA nanoparticle, application and preparation method thereof

A PLGA, phase change technology, applied in the direction of nanotechnology, nanotechnology, nanomedicine, etc., can solve the problems of out of stock and high price, and achieve the effect of reducing the cost of use and the amount of use

Inactive Publication Date: 2019-01-11
CHONGQING MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But at present, the drug has been included in the domestic medical insurance. After the medical insurance, the price of a Herceptin is 7,000 yuan, which is expensive, and the domestic Herceptin is currently out of stock.

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  • HER2-targeted phase-change PLGA nanoparticle, application and preparation method thereof
  • HER2-targeted phase-change PLGA nanoparticle, application and preparation method thereof
  • HER2-targeted phase-change PLGA nanoparticle, application and preparation method thereof

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Embodiment Construction

[0030] figure 1 Among them, 1 is human epidermal growth factor receptor 2 ligand, 2 is superparamagnetic iron oxide SPIO, 3 is liquid perfluoropentane PFP, 4 is PLGA, and 5 is PEG10000.

[0031] 1. The preparation method of the present invention targeting HER2 phase change type PLGA nanoparticles is:

[0032] 1. Materials and Instruments

[0033] Superparamagnetic iron oxide (SPIO, 10nm, Ocean Nano Tech), polylactic-glycolic acid copolymer (PLGA, 50:50, Jinan Daigang), liquid perfluoropentane (PFP, Bailingwei Technology Co., Ltd.), polyethylene Alcohol (PVA, Sigma), Herceptin (Herceptin, Roche), isopropanol, dichloromethane (Chuandong Chemical Co., Ltd.), FITC-labeled goat anti-mouse IgG antibody (abcam), EDC / NHS (Sigma), SKBR3 cell line (School of Pharmacy, Third Military Medical University), dye DiI (Beiyuntian Biotechnology Co., Ltd.). Vibration Acoustic Instrument (Sonic&Material), High Speed ​​Dispersion Homogenizer (XHF-D), Laser Particle Size Measuring Instrument (Ze...

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Abstract

The invention relates to the field of ultrasonic images, in particular to a HER2-targeted phase-change PLGA nanoparticle, an application and a preparation method thereof. The HER2-targeted phase-change PLGA nanoparticle comprises an outer shell, wherein superparamagnetic iron oxide is embedded on the outer shell, and a human epidermal growth factor receptor 2 coordination group is also linked on the outer shell; the preparation method is double emulsification method and carbodiimide method. The technical problem to be solved by the invention is to provide a low-cost, high-expression breast cancer cell specifically targeting HER2 and obviously enhance the ultrasound / photoacoustic / magnetic resonance multimodal imaging of the targeted HER2 phase-change PLGA nanoparticles used for integratingdiagnosis and treatment of breast cancer, application and preparation method thereof.

Description

technical field [0001] The invention relates to the field of ultrasound imaging, in particular to a HER2-targeting phase-change PLGA nanoparticle, its application and its preparation method. Background technique [0002] Breast cancer, as the most common tumor, seriously threatens women's health. Breast cancer imaging methods commonly used today include X-rays, ultrasound imaging, and magnetic resonance imaging. At present, these imaging methods can provide a variety of anatomical and functional information of breast tissue, but they have not yet fully met the requirements of clinical diagnosis of breast cancer. Studies have reported that mammography is not effective in reducing breast cancer mortality. Magnetic resonance imaging has a high detection rate for small tumors, but it is not economical and time-consuming, making it difficult to be used as a routine imaging method. Ultrasound imaging is difficult to judge benign and malignant breast masses smaller than 5mm. Ul...

Claims

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Application Information

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IPC IPC(8): A61K49/18A61K49/22A61K47/69A61K47/68A61K41/00A61K39/395A61P35/00A61P35/02B82Y5/00B82Y15/00
CPCA61K39/39558A61K41/0052A61K47/6849A61K47/6937A61K49/0002A61K49/183A61K49/1866A61K49/225A61K2039/505A61P35/00A61P35/02B82Y5/00B82Y15/00A61K2300/00
Inventor 邓黎明孙阳王志刚刘明珠
Owner CHONGQING MEDICAL UNIVERSITY