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Renewable universal terahertz metamaterial sensor

A sensor and general-purpose technology, applied in the direction of material analysis, analysis materials, instruments, etc. through optical means, can solve problems such as difficult to reuse, poor specificity, high detection cost, etc., and achieve stable and reliable results

Inactive Publication Date: 2019-01-15
THE FIRST AFFILIATED HOSPITAL OF ARMY MEDICAL UNIV
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Problems solved by technology

However, the direct application of MMs-based terahertz sensors to biological samples still has the following deficiencies: (1) lack of a specific recognition system and poor specificity; (2) terahertz metamaterial sensors are not reproducible and difficult to reuse , the detection cost is high, (3) The terahertz metamaterial sensors reported so far can only be used for single capture detection of protein or nucleic acid, and cannot meet the needs of simultaneous detection of multiple targets such as nucleic acid and protein

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Embodiment

[0040] Renewable general-purpose terahertz metamaterial biosensors: including terahertz metamaterial chips, general-purpose immobilized probes coated on the surface of metamaterial chips and aptamers containing specific enzyme cleavage sites, specific adapters for different targets Ligands are immobilized in different reactive modules of the metamaterial. The structure and scanning electron microscope images of terahertz metamaterials are shown in figure 1As shown, the substrate of the terahertz metamaterial is silicon, and the material selected for the metal structure is gold. The metamaterial structure is produced by photolithography, and the production process includes coating, coating, exposure, wet etching and stripping. The geometric parameters of the metamaterial include the thickness of the substrate silicon h=500 μm, the opening width g=2 μm, the distance between the rings in the structural unit d=4 μm, the width of the structural unit w=2 μm, and the thickness of th...

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Abstract

The invention relates to a renewable universal terahertz metamaterial sensor. Various types of targets to be tested are accurately captured on the surface of the metamaterial chip through the universal probe and aptamer, the specific cleavage site of the enzyme cleavage aptamer is cut by the uracil to obtain the universal reusable renewable terahertz metamaterial sensor. The rapid, unlabeled, specific and combined detection of various target targets such as pathogens and drug resistance genes thereof can be achieved by immobilizing the specific aptamers of different kinds of targets in different reaction modules of metamaterials. The number of repeated detections reached 6 times, the detection time is only 2 hours, and the lowest bacterial concentration was detected as low as 100 cfu / mL.

Description

technical field [0001] The invention belongs to the field of biological detection and relates to a reproducible general-purpose terahertz metamaterial sensor. Background technique [0002] Terahertz (terahertz, THz, 1THz = 10 12 Hz) waves are electromagnetic waves with a frequency between 0.1 and 10 THz, based on the advantages of THz for non-labelling, non-contact and non-destructive detection of chemical and biological substances. THz waves can reveal the structural and functional information of multiple biological macromolecules at the same time in a purely physical process without labeling, which may provide a revolutionary new type of pathogenic bacteria label-free detection that is completely different from the existing technology. technical means. However, the size of most microorganisms is about λ / 100 of the THz wavelength, resulting in a low scattering cross-section and thus a weak THz response signal for most bacteria. [0003] Metamaterials MMs (Metamaterials) ...

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Application Information

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IPC IPC(8): G01N21/3586
CPCG01N21/3586
Inventor 陈雪萍府伟灵张阳郭鹰田晖艳唐美琼周阳刘羽余闻静赵祥郑玉婷
Owner THE FIRST AFFILIATED HOSPITAL OF ARMY MEDICAL UNIV
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