Unlock instant, AI-driven research and patent intelligence for your innovation.

Method for preparing L-histidine-bromo-malonaldehyde acetal bis-Schiff base nickel complex

A double Schiff base, nickel complex technology, applied in nickel organic compounds, chemical instruments and methods, compounds containing periodic table Group 8/9/10/18 elements, etc., can solve unfavorable product purification and characterization, Problems such as side reactions occur, and the effects of high yield, good repeatability and simple process are achieved

Inactive Publication Date: 2019-01-18
GUILIN UNIVERSITY OF TECHNOLOGY
View PDF1 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The advantages of this method are fast reaction, high yield, and convenient and simple operation; the disadvantage is that side reactions occur, which is not conducive to the purification and characterization of the product.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for preparing L-histidine-bromo-malonaldehyde acetal bis-Schiff base nickel complex
  • Method for preparing L-histidine-bromo-malonaldehyde acetal bis-Schiff base nickel complex

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0022] (1) Weigh 1.6292 g (10 mmol) of L-histidine into a three-necked flask, add 20 mL of 50% methanol (V methanol: V water = 1:1) to form a white turbid liquid, slowly drop it while stirring Add 10 mL of 0.5892 g (10 mmol) KOH 50% methanol solution, the white turbid liquid becomes clear.

[0023] (2) Add 5 mL of 0.7548 g (5 mmol) bromomalondialdehyde 50% methanol solution dropwise to the clear solution of (1), under nitrogen protection, reflux and stir at 75°C for 4 hours, and cool to room temperature naturally. The yellowish-brown solution was obtained, which was evaporated in the refrigerator. After one day, light yellow flaky crystals were precipitated, and the precipitate was obtained by suction filtration.

[0024] (3) The precipitate obtained in (2) was washed with water (10 mL×3) and anhydrous methanol (10 mL×3) successively, and dried under vacuum at 25°C to obtain 0.3162 g of L-histidine bromopropane Dialdehyde bis-Schiff base, the yield is 14.87%, and the melting ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a method for preparing an L-histidine-bromo-malonaldehyde acetal bis-Schiff base nickel complex. The method comprises the following steps: taking L-histidine and malondialdehyde bromide as raw materials, taking a methanol-water mixed solution having a volume ratio of 1:1 as a solvent, without adding any catalyst, and preparing an L-histidine-bromo-malonaldehyde acetal bis-Schiff base; and taking the L-histidine-bromo-malonaldehyde acetal bis-Schiff base as a ligand, reacting with nickel acetate in the methanol-water mixed solution having the volume ratio of 1:1, therebyobtaining the L-histidine-bromo-malonaldehyde acetal bis-Schiff base nickel complex. The method disclosed by the invention has the advantages of being catalyst-free, simple in process, excellent in repeatability, high in yield and the like.

Description

technical field [0001] The invention belongs to the technical field of organic synthesis, in particular to a preparation method of L-histidine bromomalondialdehyde bis-Schiff base nickel complex. Background technique [0002] Schiff base refers to a class of compounds with -CH=N- and -CR=N-structures. The nitrogen atom in the Schiff base structure provides a lone pair of electrons and has strong reactivity. As long as the type and position of the Schiff base substituents are changed, a new Schiff base can be obtained by flexibly selecting amines and carbonyl-containing aldehydes or ketones, and it can be coordinated with different metals to derive many functions. Different and structurally diverse metal complexes. Schiff bases and their complexes have good antitumor, antibacterial, antioxidative, antiviral and other activities, and have good application prospects in chemical catalysis, biomedicine, functional materials, food industry and other fields, and also play an impo...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07D233/64C07F15/04
CPCC07D233/64C07F15/045
Inventor 刘峥梁秋群梁楚欣李海莹
Owner GUILIN UNIVERSITY OF TECHNOLOGY