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Preparation of dimolecular sandwich electrochemical transducer for identifying dopamine

An electrochemical and bimolecular technology, applied in the fields of electrochemical variables of materials, scientific instruments, instruments, etc., can solve the problems of expensive instruments, interfere with accuracy and precision, and time-consuming, and achieve low cost, reduce impact, and avoid volatile live effect

Inactive Publication Date: 2019-01-22
UNIV OF JINAN
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  • Claims
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Problems solved by technology

However, these methods for detecting dopamine cannot meet the needs, and there are defects such as complicated sample pretreatment, time-consuming, expensive instruments, etc.
In addition, coexisting substances in actual samples will greatly interfere with the accuracy and precision of the assay

Method used

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  • Preparation of dimolecular sandwich electrochemical transducer for identifying dopamine
  • Preparation of dimolecular sandwich electrochemical transducer for identifying dopamine
  • Preparation of dimolecular sandwich electrochemical transducer for identifying dopamine

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Embodiment Construction

[0022] Preparation and detection of a bimolecular sandwich electrochemical sensor for dopamine recognition

[0023] (1) Electrochemical deposition of gold nanoparticles on the surface of the glassy carbon electrode, the glassy carbon electrode was ultrasonically cleaned with ultrapure water and absolute ethanol for 5 min, and the electrode was placed in 5.0 mmol / L HAuCl 4 In the solution, gold nanoparticles were deposited by cyclic voltammetry, the deposition potential was -1.5-0 V, the number of scan cycles was 20, and the scan rate was 100 mV / s.

[0024] (2) Add 10 μL of 1 mmol / L 4-mercaptophenylboronic acid solution dropwise on the surface of the glassy carbon electrode prepared in step (1), and react at 4°C for 2 hours.

[0025] (3) To prepare 3,3'-dithiodipropionate bis(N-succinimide)@PdAu nanoparticle composite, mix 2.0mL 10 mmol / L Na 2 PdCl 4 solution, 0.5 mL 10 mmol / L HAuCl 4 solution, 0.1 g of cetylpyridinium chloride and 25 mL of ultrapure water were added to the ...

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Abstract

The invention prepares a dimolecular sandwich electrochemical transducer for identifying dopamine. Gold nanoparticles are subjected to electrochemical deposition on the surface of an electrode; the surface is modified with 4-mercaptophenyl boronic acid, wherein a boronic acid group of the 4-mercaptophenyl boronic acid is combined with two hydroxide radicals of the dopamine; a di(N-succinimidyl) 3,3'-dithiodipropionate @ PdAu nanoparticle compound is prepared and the di(N-succinimidyl) 3,3'-dithiodipropionate is combined with amidogen of the dopamine, wherein PdAu nanoparticles have the abilityto catalyze H2O2 to produce electrochemical signals. The two-small organic molecule type sandwich structure electrochemical transducer for identifying dopamine is prepared, and the prepared transducer provides a method of rapidly detecting dopamine with high selectivity and high sensitivity.

Description

technical field [0001] The invention relates to the technical field of dopamine detection, in particular to the preparation of a bimolecular sandwich electrochemical sensor for recognizing dopamine. Background technique [0002] Dopamine is a small organic molecule and an important catecholamine neurotransmitter, which is a key neurotransmitter in the human central nervous system and plays a key role in motivation, cognition, reward, arousal and motor control in the brain effect. Abnormal levels of dopamine in the brain can cause some disease conditions, such as a deficiency of dopamine in the motor areas of the brain can lead to Parkinson's disease, which involves uncontrollable muscle tremors, while neurological disorders such as schizophrenia, social anxiety or social phobia are associated with people It is related to the presence of excess dopamine in the body. In addition, abnormal levels of dopamine in the prefrontal cortex and frontal lobe of the brain can lead to a...

Claims

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Application Information

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IPC IPC(8): G01N27/26G01N27/30G01N27/327
CPCG01N27/26G01N27/30G01N27/3278
Inventor 葛慎光付翠萍王芳芳李娜张彦崔康赵珮妮于京华
Owner UNIV OF JINAN
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