Interference sequence of IL-17 gene closely related to primary nephrotic syndrome podocyte injury

Abstract

The present invention discloses an interference sequence of an IL-17 gene closely related to primary nephrotic syndrome podocyte injury, wherein the interference sequence is represented by SEQ ID NO.1, SEQ ID NO.2 or SEQ ID NO.3. According to the present invention, the research results show that the silencing of IL-17 with the RNAi technology can effectively inhibit the IL-17 gene expression, correct the Th17 / Treg cell immune imbalance, alleviate the IL-17-mediated podocyte injury and reduce the proteinuria production, such that the important clinical significance is achieved, the new field ofvision can be displayed for the primary nephrotic syndrome podocyte injury and the proteinuria production, and the use of the Th17 / IL-17 as the potential treatment target can be expected to develop the new ideas for the prevention and treatment of primary nephrotic syndrome and provide the theoretical basis for the future clinical reasonable intervention.

Description

technical field [0001] The invention relates to an interfering sequence of IL-17 gene closely related to podocyte injury in primary nephrotic syndrome. Background technique [0002] Primary nephrotic syndrome (PNS) is a group of immune diseases of unknown etiology in childhood. Its main clinical manifestation is a large amount of proteinuria, which then leads to persistent renal damage and eventually renal failure. It brings great physical and mental and economic burdens to the family and society. In previous studies, its clinical features, pathological features, and prognosis have been clarified, but its specific pathogenesis has not yet been fully understood. [0003] Previous studies believed that Th1 / Th2 cells play an important role in a variety of autoimmune diseases, but a large number of studies in recent years have shown that their mediated effector mechanism cannot fully explain the complex pathogenesis. The discovery of new Th17 cells, Th17 / Treg Cell balance makes...

AI Technical Summary

Problems solved by technology

[0002] Primary nephrotic syndrome (PNS) is a group of immune diseases of unknown etiology in childhood. Its main clinical manifestation is a large amount of proteinuria, which then leads to persistent renal damage and eventually renal failure. Family and society bring great physical and mental and economic burdens. In previous studies, its clinical features, pathological features, prognosis, etc. have been clarified, but its specific pathogenesis has not yet been fully understood.

Images