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Composition and composite calibration product and application of composition and composite calibration product

A technology of composition and calibrator, which is applied in the direction of composition, biological test, and material inspection product for inhibiting chemical change, can solve the problems of perishability and poor storage stability, and achieves prolonging storage time, reducing cost, and improving anti-oxidation. effect of effect

Active Publication Date: 2019-02-05
深圳天辰医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to solve the above technical problems, the main purpose of the embodiments of the present invention is to provide a composition as a folic acid protection preparation, aiming to solve the technical problems of existing folic acid calibration products that are easy to deteriorate and have poor storage stability.

Method used

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  • Composition and composite calibration product and application of composition and composite calibration product
  • Composition and composite calibration product and application of composition and composite calibration product
  • Composition and composite calibration product and application of composition and composite calibration product

Examples

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Embodiment 1

[0054] The present embodiment provides a folic acid protection preparation, comprising the following components by weight:

[0055]

[0056] In this embodiment, the synergist is selected as citric acid, the surfactant is selected as Tetronic 1307; the preservative is selected as potassium sorbate; the buffer is selected as phosphate buffer, and its phosphoric acid concentration is 100 mM.

[0057] When in use, mix folic acid and the folic acid protection preparation of the embodiment of the present invention at a mass ratio of 0.005:1 to obtain a composite calibrator, and store it in the dark at 2-8°C.

Embodiment 2

[0059] The present embodiment provides a folic acid protection preparation, comprising the following components by weight:

[0060]

[0061] In this embodiment, the synergist is selected as disodium citrate, the surfactant is selected as fatty alcohol polyoxyethylene ether sodium sulfate; the preservative is selected as sodium benzoate; the buffer is selected as Tris-HCl buffer, wherein the concentration of Tris 150mM.

[0062] When in use, mix folic acid and the folic acid protection preparation of the embodiment of the present invention at a mass ratio of 0.05:1 to obtain a composite calibrator, and store it in the dark at 2-8°C.

Embodiment 3

[0064] The present embodiment provides a folic acid protection preparation, comprising the following components by weight:

[0065]

[0066] In this embodiment, the synergist is selected as citric acid monohydrate, the surfactant is selected as the mixture of fatty alcohol polyoxyethylene ether sodium sulfate and Tetronic 1307; the preservative is selected as biological preservative; the buffer is selected as MES buffer , MES concentration was 70 mM.

[0067] When in use, mix folic acid and the folic acid protection preparation of the embodiment of the present invention at a mass ratio of 0.2:1 to obtain a composite calibrator, and store it in the dark at 2-8°C.

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Abstract

The invention belongs to the technical field of biomolecular in-vitro diagnosis, and particularly relates to a composition and a composite calibration product and application of the composition and the composite calibration product. The composition is prepared form the raw materials in parts by weight: 0.5-10 parts of triglyceride, 0.01-3 parts of butylated hydroxytoluene, 0.01-1 part of synergist, and 0.01-2 parts of surface active agent. The triglyceride is a stabilizer, and has the function of protecting liquid and dewatering protecting liquid, thereby playing a good protection role in protecting folic acid antigen. The butylated hydroxytoluene is an antioxidant, thereby reacting with the chain growth free radical produced in the automatic oxidation process to eliminate the free radicaland avoid the oxidation of folic acid. The surface active agent can replace water to form hydrogen bonds with hydrophilic groups of the folic acid to maintain stability of the folic acid in spatial structure and avoid agglomeration. The synergist and the antioxidant are mixed for application, and therefore the antioxidation effect is improved, and folic acid oxidation can be well prevented or delayed. The components are matched with each other to improve the effect, and therefore stability of the folic acid is improved, and the storage period can be prolonged.

Description

technical field [0001] The invention belongs to the technical field of biomolecular in vitro diagnosis, and specifically relates to a composition, a compound calibrator and applications thereof. Background technique [0002] Folic acid (folic acid), also known as vitamin B9, is a water-soluble B vitamin. It is an important and essential vitamin for normal cell growth and DNA synthesis in the body. Many foods contain folic acid. After entering the human body, folic acid in food is reduced to physiological functions. The active form of action is tetrahydrofolic acid (THFA), which is a carrier of one-carbon groups in biochemical reactions in vivo. Folic acid carries a carbon group to form N5-methyl THFA, methylene THFA, etc. to participate in the synthesis of purine and thymine, and further synthesize DNA and RNA. Participate in the mutual transformation between glycine and serine, between histidine and glutamic acid, between cysteine ​​and methionine, and participate in the s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N21/76G01N30/72G01N33/53G01N33/82G01N1/28C07D475/04C09K15/08
CPCC07D475/04C09K15/08G01N1/28G01N21/76G01N30/02G01N30/72G01N33/53G01N33/82G01N2001/2893
Inventor 阳云唐灿
Owner 深圳天辰医疗科技有限公司
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