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Semiconductor device and cellular potential measurement device

一种半导体、电极的技术,应用在带有半导体器件/放电管的放大器、测量装置、生物化学清洗装置等方向,能够解决放大器尺寸减小、噪声增大等问题

Active Publication Date: 2019-02-05
SONY CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since it is necessary to prepare as many amplifiers as read electrodes, the size of each amplifier is reduced, and the noise increases
As mentioned above, with the above method, there is a trade-off between noise and the number of simultaneously measured points

Method used

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  • Semiconductor device and cellular potential measurement device
  • Semiconductor device and cellular potential measurement device
  • Semiconductor device and cellular potential measurement device

Examples

Experimental program
Comparison scheme
Effect test

no. 1 approach

[0030] 1. The first embodiment: cell potential measuring equipment ( Figure 1 to Figure 4 )

no. 2 approach

[0031] 2. The second embodiment: cell potential measuring equipment ( Figure 5 and Figure 6 )

no. 3 approach

[0032] 3. The third embodiment: cell potential measuring equipment ( Figure 7 )

[0033]

[0034] (Exemplary configuration of the first embodiment of the cell potential measuring device)

[0035] figure 1 is a diagram of an exemplary configuration of the first embodiment to which the cell potential measurement device of the present disclosure is applied.

[0036] figure 1 The cell potential measuring device 10 in is a semiconductor device in which a sensing unit 11, a sensor drive line 12, a vertical signal line 13, a vertical selection circuit 14, an A / D conversion circuit 15, a horizontal selection circuit 16, an output The terminal 17 is formed on an unillustrated semiconductor substrate (chip) by using CMOS integration technology.

[0037] In the sensing unit 11 of the cell potential measurement device 10 , sensors 11A for reading the electrochemical potential of a culture solution including living cells are two-dimensionally arranged in an array (matrix). Further,...

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PUM

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Abstract

The present invention relates to a semiconductor device and a cellular potential measurement device for making it possible to amplify and read an electrical potential of a solution with high precision. In the present invention, a read electrode reads the electrical potential of a solution. A differential amplifier in the present invention has a current mirror circuit. The read electrode is connected to a first input terminal of the differential amplifier, the first input terminal being connected to the gate of a first input transistor connected to a diode-connected pMOS transistor of the current mirror circuit. An output terminal of the differential amplifier is connected via a capacitance to a second input terminal of the differential amplifier, the second input terminal being connected to the gate of a second input transistor connected to a non-diode-connected pMOS transistor of the current mirror circuit. The present invention can be applied to a cellular potential measurement device or the like, for example.

Description

technical field [0001] The present disclosure relates to a semiconductor device and a cell potential measurement device, and in particular, to a semiconductor device and a cell potential measurement device capable of amplifying and reading the potential of a solution with high precision. Background technique [0002] There is a device that measures action potentials emitted from living cells by arranging microelectrodes in an array in a culture solution including living cells and electrochemically measuring the potential of the culture solution (for example, refer to Patent Document 1 ). [0003] Among such devices, in recent years, designs have been made by integrating a large number of electrodes, amplifiers, analog / digital (A / D) converters, etc. Potentials at multiple points. [0004] A method of simultaneously measuring potential at a plurality of points includes a method of measuring potential by sequentially connecting read electrodes to a single amplifier and a meth...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/416C12M1/34C12M1/42G01N27/00
CPCC12M1/34C12M1/42H03F3/45183H03F2200/396G01N27/4148G01N27/4161H03F3/45188H03F2200/129H03F2200/156H03F2200/228H03F2200/48H03F2203/45156H03F2203/45512H03F2203/45536G01N27/416G01N27/00G01N27/3273G01N33/48728G01N33/48735
Inventor 加藤祐理大池祐辅
Owner SONY CORP