Application of deferoxamine to preparation of medicine for preventing and/or treating tumor

A tumor drug, deferoxamine technology, applied in the field of oncology, can solve the problems of adjuvant therapy that have not been reported yet, and achieve the effect of improving the therapeutic effect and enhancing the killing effect

Active Publication Date: 2019-02-12
葛鹏飞
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Although deferoxamine has been used to rescue acute iron poisoning for many years, its adjuvant therapy for tumors, especially for glioma and human lung cancer, has not been reported

Method used

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  • Application of deferoxamine to preparation of medicine for preventing and/or treating tumor
  • Application of deferoxamine to preparation of medicine for preventing and/or treating tumor
  • Application of deferoxamine to preparation of medicine for preventing and/or treating tumor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1 Desferoxamine enhances the therapeutic effect of temozolomide on glioma

[0032] 1. Reagents:

[0033] Desferrioxamine was purchased from Abcam Company, and was prepared to the required concentration with PBS solution when used.

[0034] Temozolomide was purchased from Sigma.

[0035] Human glioma U251 cells were purchased from Shanghai Jikai Biotechnology Company.

[0036] 2. Method:

[0037] (1) The preparation process of different concentrations of deferoxamine is as follows:

[0038] Dissolve deferoxamine in PBS solution to make a mother solution with a concentration of 5 mmol / L. According to the requirements of the experiment, different volumes of mother liquor were added to make the final concentration reach 125 μmol / L, 250 μmol / L, and 500 μmol / L.

[0039] (2) The preparation process of temozolomide with a concentration of 100 μmol / L is as follows:

[0040] Temozolomide was dissolved in DMSO to make a stock solution with a concentration of 50mmol / L...

Embodiment 2

[0046] Example 2 Deferoxamine enhances the therapeutic effect of temozolomide on lung cancer cells

[0047] 1. Reagents:

[0048] Desferrioxamine was purchased from Abcam Company, and was prepared to the required concentration with PBS solution when used.

[0049] Temozolomide was purchased from Sigma.

[0050] Human lung cancer A549 cells were purchased from Shanghai Jikai Biotechnology Company.

[0051] 2. Method:

[0052] (1) The preparation process of different concentrations of deferoxamine is as follows:

[0053] Dissolve deferoxamine in PBS solution to make a mother solution with a concentration of 5 mmol / L. According to the requirements of the experiment, different volumes of mother liquor were added to make the final concentration reach 250 μmol / L and 500 μmol / L.

[0054] (2) The preparation process of temozolomide with a concentration of 100 μmol / L is as follows:

[0055] Temozolomide was dissolved in DMSO to make a mother solution with a concentration of 50 mm...

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Abstract

The invention provides application of deferoxamine to preparation of medicine for preventing and/or treating tumor, and relates to the technical field of tumor science. According to the application ofdeferoxamine to the preparation of medicine for preventing and/or treating the tumor, the dose form of the medicine is an injection or a tablet; the tumor is glioma or human lung carcinoma cells. Inthe medicine, 125 to 500 mumol/L of deferoxamine and 100 mumol/L of temozolomide are contained. Through experiment methods, the result proves that the treatment effect of the temozolomide on the glioma or human lung carcinoma cells can be enhanced; the effect of cooperating with temozolomide to killing glioma or human lung carcinoma cells is achieved; the killing effect of the temozolomide on theglioma or human lung carcinoma cells can be enhanced. The deferoxamine and the temozolomide are prepared into medicine used for preventing and/or treating the glioma or human lung carcinoma cells; thetreatment effect of the temozolomide on the brain glioma or human lung carcinoma can be improved.

Description

technical field [0001] The invention relates to the technical field of oncology, in particular to the application of deferoxamine in the preparation of drugs for preventing and / or treating tumors. Background technique [0002] Glioma is the most common primary malignant intracranial tumor. It can be found in all age groups, mostly in adults, and there is no significant difference in incidence between men and women. It has the characteristics of high disability rate, high recurrence rate and high mortality rate. The treatment of glioma mainly adopts surgical resection, postoperative radiotherapy and chemotherapy, but the average postoperative survival period of patients with glioma grade III and IV (high grade) according to the WHO classification is not more than 1 year, even after surgery Treatment with radiotherapy and the current first-line chemotherapy drug Temozolomide (TMZ) can only prolong the average survival time by about half a year. Therefore, there is still a lac...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/16A61K31/4188A61P35/00
CPCA61K31/16A61K31/4188A61P35/00A61K2300/00
Inventor 葛鹏飞孟繁凯
Owner 葛鹏飞
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