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Temperature-sensitive hollow polylactic acid color changing microsphere as well as preparation method and application thereof

A technology of polylactic acid microspheres and polylactic acid, which is applied in the preparation of microspheres, microcapsule preparations, etc., achieves the effects of high stability, wide color selectivity, and wide discoloration temperature

Inactive Publication Date: 2019-02-15
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there are no patents on polylactic acid hollow microspheres and reports on temperature-sensitive hollow polylactic acid microspheres

Method used

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  • Temperature-sensitive hollow polylactic acid color changing microsphere as well as preparation method and application thereof
  • Temperature-sensitive hollow polylactic acid color changing microsphere as well as preparation method and application thereof
  • Temperature-sensitive hollow polylactic acid color changing microsphere as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] (1) Disperse 3g of polylactic acid particles in 97g of dichloromethane solution, obtain a uniform and clear polylactic acid solution after ultrasonic dispersion for 6 hours, weigh 1g of polyvinyl alcohol and dissolve it in 99g of deionized water, heat and stir at 90°C for 6 hours stand-by. Weigh 1g of ink that turns from blue to white at 38°C and disperse it in 99g of deionized water, ultrasonically disperse for 6 hours and set aside.

[0035] (2) Place the first polytetrafluoroethylene tube (1) vertically, the second polytetrafluoroethylene tube (3) is connected horizontally with the first polytetrafluoroethylene tube (1) through the first glass capillary tube (2), the second The three polytetrafluoroethylene tubes (5) are longitudinally connected to the second polytetrafluoroethylene tube (3) through the second glass capillary tube (4); all the polytetrafluoroethylene tubes and glass capillary tubes are connected with Henkel Baide AB glue Get a microfluidic device. ...

Embodiment 2

[0042] (1) Disperse 5g of polylactic acid particles in 95g of dichloromethane solution, obtain a uniform and clear polylactic acid solution after ultrasonic dispersion for 3 hours, weigh 3g of polyvinyl alcohol and dissolve it in 97g of deionized water, heat and stir at 95°C for 5 hours stand-by. Weigh 2g of ink that turns from blue to white at 38°C and disperse it in 98g of deionized water, ultrasonically disperse for 5 hours and set aside.

[0043] (2) Place the first polytetrafluoroethylene tube (1) vertically, the second polytetrafluoroethylene tube (3) is connected horizontally with the first polytetrafluoroethylene tube (1) through the first glass capillary tube (2), the second The three polytetrafluoroethylene tubes (5) are longitudinally connected to the second polytetrafluoroethylene tube (3) through the second glass capillary tube (4); all the polytetrafluoroethylene tubes and glass capillary tubes are connected with Henkel Baide AB glue Get a microfluidic device. ...

Embodiment 3

[0046] (1) Disperse 7g of polylactic acid particles in 93g of dichloromethane solution, obtain a uniform and clear polylactic acid solution after ultrasonic dispersion for 7 hours, weigh 3g of polyvinyl alcohol and dissolve it in 97g of deionized water, heat and stir at 94°C for 4 hours stand-by. Weigh 3g of ink that turns from blue to white at 38°C and disperse it in 97g of deionized water, ultrasonically disperse for 4 hours and set aside.

[0047] (2) Place the first polytetrafluoroethylene tube (1) vertically, the second polytetrafluoroethylene tube (3) is connected horizontally with the first polytetrafluoroethylene tube (1) through the first glass capillary tube (2), the second The three polytetrafluoroethylene tubes (5) are longitudinally connected to the second polytetrafluoroethylene tube (3) through the second glass capillary tube (4); all the polytetrafluoroethylene tubes and glass capillary tubes are connected with Henkel Baide AB glue Get a microfluidic device. ...

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Abstract

The invention relates to a temperature-sensitive hollow polylactic acid color changing microsphere as well as a preparation method and application thereof. The microsphere comprises polylactic acid, color changing ink and polyvinyl alcohol. The preparation method comprises the following steps of preparation of polylactic acid solution, preparation of color changing ink suspension, preparation of polyvinyl alcohol solution and preparation of the polylactic acid microsphere. The preparation method has the advantages of being high efficiency, feasible and suitable for the preparation of large-scale monodisperse functional hollow microspheres.

Description

technical field [0001] The invention belongs to the field of polymer microspheres and their preparation methods and applications, in particular to a temperature-sensitive hollow polylactic acid discoloration microspheres and their preparation methods and applications. Background technique [0002] With the advancement of medical technology, researchers have proposed new ideas for the treatment of diseases, using antibodies and cells for treatment, especially the treatment that requires long-term sustained release of drugs in the body. However, foreign substances will be rejected by the body's own immune system. Therefore, the researchers proposed hollow microspheres with a porous surface as a protective film for drug embedding or cell culture, and then injected into the human body for treatment. [0003] Polylactic acid is a polymer obtained by polymerizing lactic acid as the main raw material. The raw material source is sufficient and can be regenerated. The production pro...

Claims

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Application Information

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IPC IPC(8): B01J13/06
CPCB01J13/06
Inventor 王宏志张伟李耀刚张青红侯成义
Owner DONGHUA UNIV
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