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A kind of mineralized hydrogel and its preparation method and application

A technology of mineralized water and hydrogel, applied in the field of artificial skin, can solve the problem that artificial skin does not have both flexibility, antibacterial property and inductance, etc., and achieves the advantages of good adhesion, high pressure sensitivity and simple synthesis method. Effect

Active Publication Date: 2021-05-25
ANHUI UNIVERSITY OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to overcome the deficiencies of the prior art, the present invention proposes a multifunctional mineralized hydrogel based on chitosan and its preparation method, which intends to solve the problem that the current artificial skin does not have flexibility, antibacterial properties and sensitivity. It is hoped that the new chitosan-based hydrogel material can be applied to skin repair, artificial intelligence equipment and other fields

Method used

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  • A kind of mineralized hydrogel and its preparation method and application
  • A kind of mineralized hydrogel and its preparation method and application
  • A kind of mineralized hydrogel and its preparation method and application

Examples

Experimental program
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Embodiment 1

[0024] A method for preparing a multifunctional mineralized hydrogel, comprising the steps of:

[0025] (1) Dissolve 1.332g of anhydrous calcium chloride in 20mL of deionized water, add 3mL of polyacrylic acid (100,000 molecular weight) and stir at room temperature; In the acetic acid solution, weigh 3.5814g of disodium hydrogen phosphate dodecahydrate in 25mL deionized water at the same time, and mix the two after dissolving; (3) After magnetic stirring and mixing for 30min, slowly add the mixed solution of step (1) into step (2) In the solution, stir gently to obtain a white viscous mineralized (ACP / PAA / CS) hydrogel.

Embodiment 2

[0027] A method for preparing a multifunctional mineralized hydrogel, comprising the steps of:

[0028] (1) Dissolve 1.332g of anhydrous calcium chloride in 20mL of deionized water, add 3mL of polyacrylic acid (100,000 molecular weight) and stir at room temperature; In the acetic acid solution, weigh 3.5814g of disodium hydrogen phosphate dodecahydrate in 25mL deionized water at the same time, and mix the two after dissolving; (3) After magnetic stirring and mixing for 30min, slowly add the mixed solution of step (1) into step (2) In the solution, stir gently to obtain a white viscous mineralized (ACP / PAA / CS) hydrogel.

Embodiment 3

[0030] A method for preparing a multifunctional mineralized hydrogel, comprising the steps of:

[0031] (1) Dissolve 1.332g of anhydrous calcium chloride in 20mL of deionized water, add 2mL of polyacrylic acid (100,000 molecular weight) and stir at room temperature; (2) Weigh 0.061g of chitosan with medium molecular weight in 12mL of 0.1% In the acetic acid solution, weigh 3.5814g of disodium hydrogen phosphate dodecahydrate in 25mL deionized water at the same time, and mix the two after dissolving; (3) After magnetic stirring and mixing for 30min, slowly add the mixed solution of step (1) into step (2) In the solution, stir gently to obtain a white viscous mineralized (ACP / PAA / CS) hydrogel.

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Abstract

The invention discloses a mineralized hydrogel, a preparation method and application thereof, and belongs to the technical field of artificial skin. The mineralized hydrogel comprises the following raw material components: 3-6vol% polyacrylic acid, 0.05-0.15wt% chitosan and 18-22wt% amorphous calcium phosphate; the molecular weight of the polyacrylic acid is 100000, the chitosan The sugar is of medium molecular weight; the amorphous calcium phosphate is produced by 2-2.5 wt % of anhydrous calcium chloride and 5.5-6 wt % of disodium hydrogen phosphate dodecahydrate in the process of hydrogel formation. The synthesis method of the invention is simple, fast, mild and environmentally friendly, and the prepared mineralized hydrogel has flexibility, antibacterial properties and induction properties, so it has broad application in smart skin materials, artificial intelligence equipment, wearable devices and the like. application prospects.

Description

technical field [0001] The invention belongs to the technical field of artificial skin, and in particular relates to a mineralized hydrogel with flexibility, antibacterial properties and inductivity, and a preparation method and application thereof. Background technique [0002] Human skin is flexible and tough, and can sense small changes in the external environment, such as temperature, humidity, pressure, etc., which has led researchers to study artificial skin materials. According to statistics, the annual demand in China alone is several million cases. Before the rise of artificial skin, traditional methods were generally used to treat skin injuries. This method is easy to cause secondary damage and inconvenience to the human body, and is not suitable for the larger situation of skin damage area. Therefore, it is of great significance to study alternative human skin materials. [0003] The existing relatively good artificial skin materials are sheets or membranes made...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/075A61L27/52A61L27/60A61L27/12A61L27/16A61L27/20A61L27/54A61L27/50
CPCA61L27/12A61L27/16A61L27/20A61L27/50A61L27/52A61L27/54A61L27/60A61L2300/232A61L2300/404C08J3/075C08L33/02C08L5/08
Inventor 严菊芬朱建华韩新亚崔明芳舒家才
Owner ANHUI UNIVERSITY OF TECHNOLOGY
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