Tavanillin tartrate microencapsules and preparation method thereof

A technology of tyvanectin and tartaric acid, which is applied in the direction of microcapsules, capsule delivery, antibacterial drugs, etc., can solve the problems of high bioavailability, good uniformity, and lack, and achieve high bioavailability, high uniformity, The effect of reducing usage

Inactive Publication Date: 2019-02-26
FOSHAN STANDARD BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The object of the present invention is to provide a kind of microcapsules and preparation method thereof for the deficiencies in the prior art, aiming to solve the lack of a stable, uniform, high water-soluble, bioavailability in the prior art Problems with High Tylvalosin Tartrate Microcapsules

Method used

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  • Tavanillin tartrate microencapsules and preparation method thereof
  • Tavanillin tartrate microencapsules and preparation method thereof
  • Tavanillin tartrate microencapsules and preparation method thereof

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preparation example Construction

[0037] The preparation method of tyvalactin tartrate microcapsules comprises the following steps:

[0038] (1) Execute pre-production inspection, then collect and weigh the materials and place them separately for standby;

[0039] (2) Set the water heating temperature of the emulsification tank to 60-100°C, put some water-soluble carrier auxiliary materials, flavoring agents and food attractants into the emulsification tank, and when the temperature of the material rises to about 70-90°C, start stirring The material is completely melted;

[0040] (3) Adjust the heating temperature of the water in the emulsification tank to 75-90°C, turn on the stirring, add the remaining carrier auxiliary materials, and wait until the materials are stirred until there is no obvious accumulation, put in tivalamectin tartrate, and turn on the emulsifier 2-6 times Make the material completely emulsified and uniform, and the temperature of the material is controlled at 75-90°C;

[0041] (4), use...

specific Embodiment 1

[0047]①. Accurately weigh 5g of tyvalomectin tartrate, 64g of PEG600064g, 20g of β-cyclodextrin, 10g of water-soluble starch, 0.1g of stevioside, 0.1g of suckling pig incense, and 1g of hydroxypropyl methylcellulose for later use.

[0048] ②. Set the heating temperature of the water in the emulsification tank to 90°C, put PEG6000, stevioside, and suckling pig incense into the emulsification tank, and when the temperature of the materials rises to about 80°C, start stirring to completely melt the materials.

[0049] ③. Adjust the heating temperature of the water in the emulsification tank to 80°C, turn on the stirring, and put in β-cyclodextrin, water-soluble starch, and hydroxypropyl methylcellulose (use a special melting auxiliary material tank, use a sanitary pump or a rotor pump to transfer the materials Pump to the emulsification tank), when the material is stirred until there is no obvious accumulation, put in tyvalactin tartrate, open the emulsifier 5 times to completely ...

specific Embodiment 2

[0051] ①. Accurately weigh 10g of tyvalomectin tartrate, PEG400059g, 20g of β-cyclodextrin, 10g of water-soluble starch, 0.1g of stevioside, 0.1g of anorectic peptide, and 0.8g of hydroxypropyl methylcellulose for later use.

[0052] ②. Set the water heating temperature of the emulsification tank to 90°C, put PEG6000, stevioside, and attractant peptide into the emulsification tank, and when the temperature of the materials rises to about 80°C, start stirring to completely melt the materials.

[0053] ③. Adjust the water heating temperature of the emulsification tank to 85°C, turn on the stirring, and put in β-cyclodextrin, water-soluble starch, and hydroxypropyl methylcellulose (use a special melting auxiliary material tank, use a sanitary pump or a rotor pump to transfer the materials Pump to the emulsification tank), when the material is stirred until there is no obvious accumulation, put in tyvalactin tartrate, open the emulsifier 5 times to completely emulsify the material ...

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Abstract

The invention relates to the technical field of veterinary drug preparations, and discloses tavanillin tartrate microencapsules comprising the components by the mass percentage: 5-30% of tavanillin tartrate, 70-95% of a water-soluble carrier auxiliary material, 0.01-0.1% of a flavor correctant and 0.01-0.1% of a food attractant. The invention also discloses a preparation method for preparing the tavanillin tartrate microencapsules. The tavanillin tartrate microencapsules and the preparation method thereof provided by the invention have the following advantages: 1) the tavanillin tartrate microencapsules have the advantages of high stability, good palatability, high efficiency, low toxicity, low residue and high bioavailability, and can reduce the use amount of various drugs and reduce thepollution and residues caused by various drugs; 2) the tavanillin tartrate microencapsules have the advantages of smooth surface, continuous function, seamlessness, high uniformity, uniform particle size and small static electricity, and improves the liquidity and dispersity of tavanillin tartrate; and 3) the preparation method provided by the invention has the advantages of simple process, convenient operation, reduction of dust pollution and easy realization of industrialization.

Description

technical field [0001] The present invention relates to the technical field of veterinary medicine preparation, be specifically related to a kind of tyvalactin tartrate microcapsule and preparation method thereof. Background technique [0002] Tylosin tartrate (Acetylisovalery Tylosion Tartrate) is a brand-new macrolide antibiotic that was commercially used for the first time by the British Yike Animal Health Products Co., Ltd. It is a derivative of tylosin; , low toxicity and low residue have quickly been recognized by farmers, and it is now the latest special drug for the treatment and prevention of poultry respiratory diseases recognized in the world. Therefore, tyvanectin has broad market application prospects. [0003] At present, there are only two formulations of veterinary drug-related quality standards on the domestic market: tyvalectin tartrate soluble powder and tyvalectin tartrate premix. Sexuality is big, can't reach more ideal effect. Moreover, the method of ...

Claims

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Application Information

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IPC IPC(8): A61K9/50A61K31/7048A61K47/10A61K47/36A61K47/38A61K47/40A61K47/02A61P11/00A61P31/04
CPCA61K9/485A61K9/4866A61K9/50A61K9/5089A61K31/7048A61P11/00A61P31/04
Inventor 赵汝芳刘肖娟王俊谭志坚黎剑坤符德文黄显会
Owner FOSHAN STANDARD BIO TECH
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