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A kind of preparation method of broken wall decoction pieces of Tibetan gastrodia elata

A technology of broken wall decoction pieces and gastrodia elata, applied in the field of medicine, can solve the problems that active ingredients such as gastrodia elata polysaccharides are easily destroyed, cannot ensure that the microbial content of the product reaches the standard, and the content of the extract of the broken wall decoction pieces of gastrodia elata is low, and it is easy to reach the wall breaking rate index. The effect of controlling and saving valuable medicinal material resources and high dissolution rate

Active Publication Date: 2021-05-25
GUANGZHOU HANFANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The sterilization process of this method is cumbersome, time-consuming, and time-costly, and the coarse powder is easily contaminated by bacteria, mold and other microorganisms in the subsequent operation process after sterilization, and it cannot ensure that the microbial content of the product after granulation reaches the standard
[0007] The patent with the publication number CN107802746A discloses "Gastrodia elata broken wall decoction pieces and its preparation method". The extract content of Gastrodia elata broken wall decoction pieces obtained by this method is low, and active ingredients such as Gastrodia elata polysaccharides cannot be fully utilized.
[0008] According to the current technology, the active ingredients such as Gastrodia elata polysaccharides in the prepared Gastrodia elata broken wall decoction pieces are easily destroyed, the preparation process is easily contaminated by microorganisms, the process is time-consuming, the content of extracts such as Gastrodia elata polysaccharides is low, and the degree of dissolution is low

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Take 2kg of fresh Tibetan Gastrodia elata, wash and steam blast (the pressure of steam explosion is 1.2MPa, the moisture content of Tibetan Gastrodia elata is 10%, and the time for maintaining the pressure is 1.0min) as coarse slag, and the coarse slag is dried under reduced pressure at 45 ° C for 3 hours After (the moisture content of the dried coarse slag is 5%), the ultrafine pulverization technology is used to crush it into ultrafine powder, and the microorganisms in the ultrafine powder of Tibetan Gastrodia are routinely detected; The wall rate is 99.6% respectively; add a certain concentration of ethanol to granulate, after the granules are dried under reduced pressure at 40°C for 3 hours, the upper layer 30 mesh and the lower layer 100 mesh shaker granulator is used to granulate 2 times, and the granules are divided into pieces to obtain Gastrodia elata. wall pieces.

[0029] The broken wall decoction pieces of Tibetan Gastrodia elata prepared in this example hav...

Embodiment 2

[0031] Take 2.5kg of fresh Tibetan Gastrodia elata after washing and steam explosion (the pressure of steam explosion is 1.8MPa, the moisture content of Tibetan Gastrodia elata is 80%, and the time for maintaining the pressure is 10min) as coarse slag, and the coarse slag is dried under reduced pressure at 45 ° C for 3 hours After (the moisture content of the dried coarse slag is 12%), the ultrafine pulverization technology is used to crush it into ultrafine powder, and the microorganisms in the ultrafine powder of Tibetan gastrodia are routinely detected; Add a certain concentration of ethanol to granulate, and after the granules are dried under reduced pressure at 45°C for 2.5 hours, the upper layer is 30 mesh and the lower layer is 100 mesh oscillating granulator to granulate once.

[0032] The broken-wall decoction pieces of Tibetan Gastrodia elata prepared in this example have bacterial, mold, yeast and coliform groups of 16, 12, 15, and 19 cfu / g, respectively, which are l...

Embodiment 3

[0034] Take 2.5kg of fresh Tibetan Gastrodia elata after washing and steam explosion (the pressure of steam explosion is 1.5MPa, the moisture content of Tibetan Gastrodia elata is 50%, and the time of maintaining the pressure is 5min) as coarse slag, and the coarse slag is dried under reduced pressure at 45 ° C for 3 hours Then (the moisture content of the dried coarse slag is 8%), it is crushed into ultra-fine powder by ultra-fine pulverization technology, and the microorganisms in the ultra-fine powder of Tibetan Gastrodia are routinely detected; Add a certain concentration of ethanol to granulate, and after the granules are dried under reduced pressure at 30°C for 3.5 hours, the upper layer is 30 mesh and the lower layer is 100 mesh oscillating granulator for 3 times.

[0035] The broken-wall decoction pieces of Tibetan Gastrodia elata prepared in this example have bacteria, mold, yeast and coliform groups of 13, 18, 10, and 10 cfu / g, respectively, which are less than 10 cfu...

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Abstract

The invention relates to a preparation method of broken-wall decoction pieces of Tibetan gastrodia elata, belonging to the technical field of medicine. The preparation method of the present invention comprises the following steps: (1) crushing Gastrodia elata into coarse slag through steam explosion technology; (2) drying the coarse slag; then adopting ultrafine crushing technology to crush it into ultrafine powder, using parenchyma cells as The index characteristic cells determine the wall breaking rate of the ultrafine powder of Gastrodia elata, and obtain the ultrafine powder with the breaking rate reaching the standard; (3) granulate the ultrafine powder with a solvent, dry, granulate, and subpackage to obtain the Tibetan gastrodia elata. Gastrodia elata broken wall decoction pieces. The broken wall decoction pieces of Tibetan gastrodia elata prepared by the method of the invention have high wall breaking rate, high dissolution rate of gastrodia elata polysaccharide, rapid dissolution of particles in water, fast dissolution rate of medicinal components, and the obtained product is easier to control the limit of microorganisms, and can ensure safe and effective medication.

Description

technical field [0001] The invention relates to a preparation method of a broken wall decoction piece of Tibetan Gastrodia elata, and belongs to the technical field of medicine. Background technique [0002] Tibetan Gastrodia, also known as Duyaozhi, Helicao, Shencao, Tianma Ma, Bailong, is a perennial herb of the Orchidaceae Gastrodia. The rhizomes are thick, without green leaves, and the capsules are obovate-elliptic, often propagated by tubers or seeds. Its rhizome is used as medicine to treat dizziness, limb numbness, convulsions in children, etc. It is a precious medicinal material. It is used in combination with Qiongzhen Ganoderma lucidum to treat headache and insomnia. Most of the Tibetan Gastrodia is in the wild state, and the number of artificially planted is less than that of Yungui Gastrodia. It is also quite harsh when collecting, and must be dug out by hand. Therefore, it is relatively difficult to see Tibetan Gastrodia in the market, which shows the preciousn...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8988A61K125/00
CPCA61K36/8988A61K2236/15A61K2236/17
Inventor 蔡鸿飞龙海林袁诚张懿许文东李康强李海波潘裕清杨阳蒋兆健刘菊妍
Owner GUANGZHOU HANFANG PHARMA