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Collagen coral hydroxyapatite composite bone filling scaffold material and its preparation method

A coral hydroxyapatite and scaffold material technology, applied in the field of bone filling scaffolds, can solve the problems of lack of availability and poor shaping, and achieve the effects of good mechanical support, easy use, good biocompatibility and biological activity

Active Publication Date: 2021-03-19
北京市意华健科贸有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In view of this, the main purpose of the present invention is to provide a collagen coral hydroxyapatite composite bone filling scaffold material and its preparation method. Through this technical solution, not only can effectively avoid the risk of disease transmission in natural tissue extraction, It also has a natural pore structure that artificially synthesized hydroxyapatite does not have, which solves the disadvantage that coral hydroxyapatite particles are not easy to shape, and uses thermal crosslinking to treat the material of the composite bone filling scaffold, which can make collagen It can still maintain a certain mechanical support in a physiological environment, and thermal cross-linking is a green cross-linking method

Method used

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  • Collagen coral hydroxyapatite composite bone filling scaffold material and its preparation method
  • Collagen coral hydroxyapatite composite bone filling scaffold material and its preparation method
  • Collagen coral hydroxyapatite composite bone filling scaffold material and its preparation method

Examples

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Effect test

Embodiment 1

[0037] (1) Cut the bovine type Ⅰ collagen sponge into pieces with a particle size of 0.5mm~1mm, and disperse the bovine type Ⅰ collagen sponge in purified water. The bovine type Ⅰ collagen sponge and purified water The weight ratio is 1.8%: 1, and the homogenization treatment is carried out at 30 rpm by a homogenizer, and the collagen slurry is obtained after 10 minutes of treatment;

[0038] (2) Mix coral hydroxyapatite particles with a particle size of 0.1mm~1mm with the collagen slurry in (1), and use a magnetic stirrer to mix and stir at a speed of 15 rpm for 15 minutes. A mixed slurry of collagen slurry and coral hydroxyapatite is obtained, and the weight ratio of bovine type I collagen sponge and coral hydroxyapatite in the mixed slurry is 1:8;

[0039] (3) Transfer the mixed slurry in (2) to a mold for compression and water removal for 12 hours, and then freeze-dry for 48 hours to obtain a freeze-formed collagen coral hydroxyapatite scaffold;

[0040] (4) The cryoforme...

Embodiment 2

[0042] (1) Cut the porcine type Ⅰ collagen sponge into pieces with a particle size of 1mm~5mm, and disperse the porcine type Ⅰ collagen sponge in purified water. The weight of the porcine type Ⅰ collagen sponge and purified water The ratio is 2.0%: 1. Use a homogenizer to perform homogenization treatment at 30 rpm, and process for 10 minutes to obtain collagen slurry;

[0043] (2) Mix coral hydroxyapatite particles with a particle size of 0.1mm~1mm with the collagen slurry in (1), and use a magnetic stirrer to mix and stir at a speed of 15 rpm for 15 minutes. Obtain the mixed slurry of collagen slurry and coral hydroxyapatite, in the mixed slurry, the weight ratio of pig source type I collagen sponge and coral hydroxyapatite is 1:9;

[0044] (3) Transfer the mixed slurry in (2) to a mold for compression and water removal for 12 hours, and then freeze-dry for 48 hours to obtain the formed collagen coral hydroxyapatite scaffold material;

[0045] (4) The scaffold material in (3) ...

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Abstract

The invention relates to a collagen coralline hydroxyapatite composite bone filling scaffold material and a material preparation method thereof. The preparation method comprises the steps: cutting collagen sponge into pieces, carrying out homogenization treatment to obtain original slurry, and mixing coralline hydroxyapatite particles with the collagen slurry to obtain collagen coralline hydroxyapatite mixed slurry; putting the collagen coralline hydroxyapatite mixed slurry into a mould, compressing, dehydrating and freeze-drying to obtain a freeze-formed collagen coralline hydroxyapatite scaffold; and carrying out thermal crosslinking treatment to obtain a final collagen coralline hydroxyapatite composite scaffold. Through the preparation method, the coralline hydroxyapatite particles andthe collagen are perfectly compounded, the coralline hydroxyapatite particles are strictly bound, the shaping problem of the coralline hydroxyapatite particles is solved, collagen can still maintaina certain mechanical support in a physiological environment, and the bone filling scaffold material with good biocompatibility and biological activity is prepared.

Description

technical field [0001] The invention relates to a bone filling bracket, in particular to a collagen coral hydroxyapatite composite bone filling bracket material and a preparation method thereof. Background technique [0002] Bone defects caused by accidents, tumors, osteoporosis, etc. are very common clinical diseases. [0003] Large bone defects exceeding the critical size are difficult to heal by themselves. Clinically, large bone defects with a critical size are often treated by autologous bone grafting, but autologous bone grafting will cause secondary damage to the patient, and at the same time provide The autologous bone is also very limited, and the allogeneic bone graft will bring the risk of immune response and disease transmission. Therefore, tissue engineering bone filling scaffold materials have a wide range of clinical application requirements. [0004] In the research field of bone filling materials, the main research content focuses on two aspects: one is to ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/42
CPCA61L27/425A61L2430/02
Inventor 莫秀梅叶凯强肖阳
Owner 北京市意华健科贸有限责任公司
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