Biodegradable photopolymerizable polymer composite material by layered manufacturing and its application

A technology of laminated manufacturing and composite materials, which is applied in the field of biodegradable photopolymerized polymer composite materials, can solve the problems of difficult adjustment of hardness and elasticity, difficult prediction of degradation characteristics, and difficulty in forming materials, so as to reduce the inconvenience of use and Effect of design constraints

Active Publication Date: 2019-02-26
王洁
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] In order to improve the mechanical strength, softness and elasticity of the existing biomedical materials that are difficult to control, and the material forming and degradation characteristics are not easy to predict, the present invention provides a biodegradable photopolymerizable polymer composite material that can be manufactured by lamination. And its application, in addition to having excellent biocompatibility and bioabsorbability, it can also achieve the advantages of adjusting physical properties, degradation degree, degradation pattern, and rate through different formula ratios, and can be manufactured by layering ( 3D printing), the biodegradable photopolymer composite material that can be manufactured by lamination includes: PGSA, a photoinitiator with biocompatibility, and a photoinitiator selected from PCL-DA and PEG-DA group

Method used

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  • Biodegradable photopolymerizable polymer composite material by layered manufacturing and its application
  • Biodegradable photopolymerizable polymer composite material by layered manufacturing and its application
  • Biodegradable photopolymerizable polymer composite material by layered manufacturing and its application

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Embodiment Construction

[0028] A biodegradable photopolymerizable polymer composite material that can be manufactured by lamination, which includes PGSA (Poly (glycerol sebacate acrylate)), a photoinitiator, and a photoinitiator selected from PCL-DA (Polycaprolactone-diacrylate), PEG-DA (Polyethyleneglycol -diacrylate), the degree of acrylation of the PGSA is preferably between 5% and 60%, more preferably between 7% and 30%.

[0029] The PGSA, PCL-DA and PEG-DA used in the present invention are all materials with biocompatibility and good degradability, and the present invention selects PCL-DA and PEG-DA containing acrylic acid group (Diarcylate, DA) to make PGSA, After PCL-DA and PEG-DA are laminated and formed by light, a better cross-linked network can be formed between the material molecules.

[0030] The photoinitiator used in the present invention preferably also has biocompatibility, which is mainly a component that can make the material photocurable when the present invention is manufactured ...

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Abstract

The invention relates to a biodegradable photopolymerizable polymer composite material by layered manufacturing and its application. The biodegradable photopolymerizable polymer composite material hasexcellent biocompatibility and bioabsorbability, has the advantages of adjusting physical properties and degradation degree, degradation forms or rate through different formulation ratios of the materials, is an excellent biomedical material and tissue engineering material, which comprises PGSA, a photoinitiator having biological compatibility and a group selected from PCL-DA, and PEG-DA. The material adopts the different ratios of the materials such as PGSA, PCL-DA and PEG-DA, and can adaptively produce the materials having different soft elasticity, mechanical properties, degradation formsand extensibility, and is suitable for manufacturing different tissues in organism, organs or the related products.

Description

technical field [0001] The invention relates to a biodegradable photopolymerizable polymer composite material, in particular to a biodegradable photopolymerizable polymer composite material suitable for lamination manufacturing. Background technique [0002] Biomedical materials are materials applied to medical equipment or tissue engineering, which can interact with organs, tissues and systems in living organisms, and can be used to repair or even directly replace biological living systems, and can perform the functions of the systems smoothly. The function of materials mainly includes replacing damaged and functionally missing parts of organisms, assisting wound healing and repairing, enhancing the function of organs and tissues, or directly replacing defective and abnormal tissues and organs, etc. Since biomedical materials may be directly applied to living organisms, in addition to the general physical and chemical properties, it is necessary to further consider their bi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/58A61L27/50A61L27/16A61L27/18
CPCA61L27/16A61L27/18A61L27/50A61L27/58A61L2430/06A61L2430/20A61L2430/28B33Y70/00C08L23/14C08L67/04C08L71/02
Inventor 王洁郑逸琳陈怡文谢明佑
Owner 王洁
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