Biodegradable photopolymerizable polymer composites and their applications

A layered manufacturing and composite material technology, applied in tissue regeneration, additive processing, prostheses, etc., can solve the problems of softness, hardness and elasticity that are difficult to control, degradation characteristics are not easy to predict, and material forming is not easy, so as to reduce the inconvenience of use The effect of design constraints with

Active Publication Date: 2021-09-17
王洁
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to improve the mechanical strength, softness and elasticity of the existing biomedical materials that are difficult to control, and the material forming and degradation characteristics are not easy to predict, the present invention provides a biodegradable photopolymerizable polymer composite material that can be manufactured by lamination. And its application, in addition to having excellent biocompatibility and bioabsorbability, it can also achieve the advantages of adjusting physical properties, degradation degree, degradation pattern, and rate through different formula ratios, and can be manufactured by layering ( 3D printing), the biodegradable photopolymer composite material that can be manufactured by lamination includes: PGSA, a photoinitiator with biocompatibility, and a photoinitiator selected from PCL-DA and PEG-DA group

Method used

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  • Biodegradable photopolymerizable polymer composites and their applications
  • Biodegradable photopolymerizable polymer composites and their applications
  • Biodegradable photopolymerizable polymer composites and their applications

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Embodiment Construction

[0028] A biodegradable photopolymerizable polymer composite material that can be manufactured by lamination, which includes PGSA (Poly (glycerol sebacate acrylate)), a photoinitiator, and a photoinitiator selected from PCL-DA (Polycaprolactone-diacrylate), PEG-DA (Polyethyleneglycol -diacrylate), the PGSA has a degree of acrylation preferably between 5% and 60%, more preferably between 7% and 30%.

[0029] The PGSA, PCL-DA and PEG-DA used in the present invention are all materials with biocompatibility and good degradability, and the present invention selects PCL-DA and PEG-DA containing acrylic acid group (Diarcylate, DA) to make PGSA, After PCL-DA and PEG-DA are laminated and formed by light, a better cross-linked network can be formed between the material molecules.

[0030] The photoinitiator used in the present invention preferably also has biocompatibility, which is mainly a component that can make the material photocurable when the present invention is manufactured by l...

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Abstract

The invention relates to a biodegradable photopolymerizable polymer composite material that can be manufactured by lamination and its application. It has excellent biocompatibility and bioabsorbability, and can also adjust physical properties through different formula ratios between materials. The advantages of properties and degradation degree, degradation pattern or rate are an excellent biomedical material and tissue engineering material, which includes PGSA, a biocompatible photoinitiator and selected from PCL-DA, PEG-DA Composed of groups; the present invention can adaptively produce materials with different soft elasticity, mechanical properties, degradation patterns and extensibility through different material ratios such as PGSA, PCL-DA and PEG-DA, and is suitable for making biological Different tissues, organs or their related products in the body.

Description

technical field [0001] The invention relates to a biodegradable photopolymerizable polymer composite material, in particular to a biodegradable photopolymerizable polymer composite material suitable for lamination manufacturing. Background technique [0002] Biomedical materials are materials applied to medical equipment or tissue engineering, which can interact with organs, tissues and systems in living organisms, and can be used to repair or even directly replace biological living systems, and can perform the functions of the systems smoothly. The function of materials mainly includes replacing damaged and functionally missing parts of organisms, assisting wound healing and repairing, enhancing the function of organs and tissues, or directly replacing defective and abnormal tissues and organs, etc. Since biomedical materials may be directly applied to living organisms, in addition to the general physical and chemical properties, it is necessary to further consider their bi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/58A61L27/50A61L27/16A61L27/18
CPCA61L27/16A61L27/18A61L27/50A61L27/58A61L2430/06A61L2430/20A61L2430/28B33Y70/00C08L23/14C08L67/04C08L71/02
Inventor 王洁郑逸琳陈怡文谢明佑
Owner 王洁
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