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A kind of absorbable suture and preparation method thereof

A technique of suture and silk thread, which is applied in the field of biomaterial preparation to achieve the effect of maintaining mechanical strength

Active Publication Date: 2021-01-29
ZHEJIANG XINGYUE BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these three types of absorbable sutures still have some defects in use and need to be improved

Method used

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  • A kind of absorbable suture and preparation method thereof
  • A kind of absorbable suture and preparation method thereof
  • A kind of absorbable suture and preparation method thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0040] The preparation method of the above-mentioned absorbable suture, comprising,

[0041] Weaving step: interweave and weave multiple strands of silk threads to obtain the suture body;

[0042] Desericin removal step: After heating the degumming agent solution, soak the suture main body in the degumming agent, maintain the water temperature, then take out the suture main body, wash the suture main body with water for 1-10 times, repeat degumming agent soaking and washing step 2 -After 6 times, dry to get absorbable uncoated suture;

[0043] Coating step: Soak the absorbable uncoated suture in the silk fibroin solution, take it out and dry it, repeat 1-5 times to get the coated suture;

[0044] Forming step: the coated suture is cross-linked to obtain absorbable suture.

[0045] As a further embodiment, in the desericin step, the degumming agent is 0.01-0.03 mol / L sodium carbonate, 0.04-0.08 mol / L sodium bicarbonate or 3-5 mol / L calcium chloride.

[0046] As a further emb...

Embodiment 1

[0053] An absorbable suture prepared as follows:

[0054] Weaving step: interweave 140 mulberry silk threads and weave them in a core-wrapping manner. The inner core is 12 silk threads to obtain the suture body;

[0055]Desericin removal step: heat the degumming agent solution to 100°C, soak the suture main body in the degumming agent, the mass volume ratio of the suture main body and the degumming agent is 1g: 200mL, maintain the water temperature for 30 minutes, and the degumming agent is 0.03mol / L sodium carbonate solution, then take out the suture main body, and then wash the suture main body once with water, the mass volume ratio of the suture main body and water is 1g:100mL, repeat the degumming agent soaking and water washing steps for 3 times, dry, dry The temperature is 80°C, and the drying time is 6 hours to obtain absorbable uncoated sutures;

[0056] Coating step: Soak the absorbable uncoated suture in the silk fibroin solution, the concentration of the silk fibr...

Embodiment 2

[0059] An absorbable suture prepared as follows:

[0060] Weaving step: interweaving and weaving 80 strands of silk threads, each strand containing 5 mulberry silks, to obtain the main body of the suture;

[0061] Desericin removal step: heat the degumming agent solution to 90°C, soak the suture body in the degumming agent, the mass volume ratio of the suture main body and the degumming agent is 1g: 100mL, maintain the water temperature for 60 minutes, and the degumming agent is 0.08mol / L of sodium bicarbonate solution, then take out the suture main body, and then wash the suture main body with water for 3 times, the mass volume ratio of the suture main body and water is 1g:100mL, repeat the degumming agent soaking and water washing steps for 3 times, dry, The drying temperature is 60°C and the drying time is 12 hours to obtain absorbable uncoated sutures;

[0062] Coating step: Soak the absorbable uncoated suture in the silk fibroin solution, the concentration of the silk f...

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Abstract

The invention discloses an absorbable suture, which is prepared from a suture main body obtained by intertwining and weaving multiple strands of silk thread, and then processing the suture main body. The number of silk threads is 8-140, and the silk thread is Natural mulberry silk. The invention also provides a preparation method of the absorbable suture. The absorbable suture of the present invention uses natural silk as raw material to obtain high-purity, high-strength absorbable silk suture, which can not only be used for general soft tissue surgical suture, but also can be used for meniscus, rotator cuff tissue, tendon and ligament Surgical suturing of tissues that repair slowly and have high mechanical requirements, such as tissues, meets clinical needs.

Description

technical field [0001] The invention relates to the field of biomaterial preparation, in particular to an absorbable suture and a preparation method thereof. Background technique [0002] At present, the sutures used for meniscus, tendons, ligaments and other load-bearing tissues on the market are all non-absorbable sutures. In the early stage of tissue healing, it can temporarily replace the tissue and provide mechanical connection or support function. After the tissue heals, it still exists in the body in the form of a foreign body. Generally, a second operation is required to remove the thread. Otherwise, there may be problems affecting the continued healing of the tissue. The problem is especially obvious for adolescents whose body tissues or organs are in the growth period. Absorbable sutures can make up for this deficiency. [0003] According to the survey, the current use of absorbable sutures only accounts for about 15% of all sutures, and its components are mainly...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): D02G3/02D02G3/44A61L17/08A61L17/14D06M15/15D06M101/12
CPCA61L17/08A61L17/145D02G3/02D02G3/448D06M15/15D06M2101/12D10B2211/04
Inventor 汪燕艳赵洪石陈隆坤
Owner ZHEJIANG XINGYUE BIOTECH
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