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Portable Fourier infrared spectroscopy disease diagnosis system for bone nonunion broken end

A technology of infrared spectroscopy and disease diagnosis, applied in the direction of using spectral diagnosis, diagnosis, diagnostic recording/measurement, etc., can solve the problems of patient tissue damage, lack of objectivity, quantitative standards, rapid and effective judgment, etc.

Inactive Publication Date: 2019-03-01
乔之光
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Current methods for nonunion types are generally invasive and cause some damage to patient tissue during the sample extraction process
At the same time, according to the results of radiographic images, the rough judgment based on the shape and size of the stump or the evaluation criteria based on bone density, the number of fibroblasts, and local blood vessels also lack objective and quantitative standards.
During surgery, osteotomy is required for some types of nonunions. Doctors generally judge the position of osteotomy based on clinical experience, the color of the stump tissue and the size of the medullary cavity. Quantitative standards for quick and efficient judgment

Method used

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  • Portable Fourier infrared spectroscopy disease diagnosis system for bone nonunion broken end
  • Portable Fourier infrared spectroscopy disease diagnosis system for bone nonunion broken end
  • Portable Fourier infrared spectroscopy disease diagnosis system for bone nonunion broken end

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] (Intraoperative identification of hypertrophic nonunion and accurate osteotomy location judgment) Help clinicians find the osteotomy location and reduce unnecessary loss of high-quality bone at the nonunion stump. A portable Fourier transform infrared spectrometer was used to continuously collect infrared spectrograms at 10 sites along the osteotomy area during the operation, and the same site was scanned continuously 16 times and the average spectrum was taken as the final spectrogram of the site. The wavelength of the obtained infrared spectrum is located at 4000-700cm -1 , with a spectral resolution of 4 cm -1 . Import the obtained infrared spectrum into the OMNIC8.0 spectral analysis software, and the original data is subjected to baseline correction in turn, changing the data point interval, peak fitting processing, and then exporting the fingerprint area 1800-800cm -1 data in the range. The processed data were imported into SMICA14.0 for OPLS-DA analysis to deter...

Embodiment 2

[0038] Intraoperative differential diagnosis of nonunion types, differentiation of hypertrophic nonunion and atrophic nonunion, to guide the selection of different follow-up diagnosis and treatment options. A portable Fourier transform infrared spectrometer was used to randomly collect infrared spectrograms at 10 sites in the nonunion area during surgery, and the same site was scanned continuously 16 times, and the average spectrum was taken as the final spectrogram of the site. The wavelength of the obtained infrared spectrum is located at 4000-700cm -1 , with a spectral resolution of 4 cm -1 . Import the obtained infrared spectrum into the OMNIC8.0 spectral analysis software, and the original data is subjected to baseline correction in turn, changing the data point interval, peak fitting processing, and then exporting the fingerprint area 1800-800cm -1 data in the range. The processed data was imported into SMICA14.0 for OPLS-DA analysis, and it was found that more than 5...

Embodiment 3

[0040] Intraoperative differential diagnosis of nonunion types, identification of infectious nonunion and aseptic nonunion, to guide the selection of different follow-up diagnosis and treatment options. A portable Fourier transform infrared spectrometer was used to randomly collect infrared spectrograms at 10 sites in the nonunion area during surgery, and the same site was scanned continuously 16 times, and the average spectrum was taken as the final spectrogram of the site. The wavelength of the obtained infrared spectrum is located at 4000-700cm -1 , with a spectral resolution of 4 cm -1 . Import the obtained infrared spectrum into the OMNIC8.0 spectral analysis software, and the original data is subjected to baseline correction in turn, changing the data point interval, peak fitting processing, and then exporting the fingerprint area 1800-800cm -1 data in the range. The processed data was imported into SMICA14.0 for OPLS-DA analysis, and more than 50% of the sites were j...

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Abstract

The invention provides a portable Fourier infrared spectroscopy disease diagnosis system for a bone nonunion broken end. The system comprises a portable Fourier transform infrared spectrometer and anautomatic judging module adopting electric signal connection. The portable Fourier infrared spectroscopy disease diagnosis system for the bone nonunion broken end is used for carrying out disease diagnosis on a bone nonunion broken end sample. Based on the classification method of a support vector machine (SVM), the rapid differential diagnosis can be carried out on the bone nonunion type of patients during the surgery, and meanwhile, clinical guidance is provided for a clinician for accurately judging the osteotomy position of the bone nonunion broken end during the surgery. In addition, thedevice has the function of machine automatic learning, according to the increase of detected cases, the judging module can realize automatic updating and optimizing, and thus the accuracy rate in diagnosing the bone nonunion type and the efficiency in judging the osteotomy position during the surgery are improved.

Description

technical field [0001] The invention relates to the field of disease diagnosis of nonunion ends, in particular to a portable Fourier transform infrared spectrum automatic diagnosis system for disease states of nonunion ends combined with machine learning. Background technique [0002] Fracture nonunion (nonunion) is defined as no signs of recovery within 3 months in patients with a history of fractures of at least 9 months. Common sites of nonunion include the femur, tibia and fibula, humeral shaft, and radius and ulna. Taken together, there is a 5%-10% incidence of nonunion after limb fracture treatment. There are many types of nonunions, including hypertrophic, atrophic, aseptic, and infectious. Different types of nonunion diseases are treated differently, which makes treating nonunions more difficult. Nonunion will lead to limited movement of the affected limb and reduce the quality of life of the patient. In addition, multiple operations will also cause long-term and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/00
CPCA61B5/0075
Inventor 乔之光王一成丛雨轩戴尅戎俞超王晓庆唐佳昕王瑞斌侯静文
Owner 乔之光
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