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Extraction method applicable to water-soluble thermal-sensitive components of traditional Chinese medicines

An extraction method and water-soluble technology, applied in the field of extraction of water-soluble heat-sensitive components of traditional Chinese medicine, can solve problems such as affecting the efficacy of formula granules, damage to heat-sensitive components, etc., so as to reduce the risk of failure, increase the content of heat-sensitive components, reduce effect of loss

Pending Publication Date: 2019-03-01
SHINEWAY PHARMA GRP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at the problem that the existing extraction process of traditional Chinese medicine greatly damages heat-sensitive components in medicinal materials and seriously affects the efficacy of formula granules, the present invention provides an extraction method suitable for water-soluble heat-sensitive components of traditional Chinese medicine

Method used

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  • Extraction method applicable to water-soluble thermal-sensitive components of traditional Chinese medicines
  • Extraction method applicable to water-soluble thermal-sensitive components of traditional Chinese medicines
  • Extraction method applicable to water-soluble thermal-sensitive components of traditional Chinese medicines

Examples

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Effect test

Embodiment 1

[0040] A kind of extraction method of honeysuckle medicinal material:

[0041] Weigh 20Kg of honeysuckle decoction pieces, remove visible foreign matter and impurities, put the honeysuckle decoction pieces into a static multifunctional extraction tank, add 95-100°C boiling water 10 times the weight of honeysuckle medicinal materials, turn on bypass heating, the temperature is 95-100°C, soak Extract for 30 minutes, filter; add 95-100°C boiling water 8 times the weight of honeysuckle to the medicinal residue, turn on bypass heating, keep warm at 95-100°C, soak and extract for 20 minutes, filter; combine the secondary extracts, Import the extract into a vacuum single-effect concentration tank, turn on the steam valve and vacuum pump, and carry out vacuum drying at a pressure of -0.08MPa, a concentration temperature of 60°C, and a relative density of 1.04 (60°C). In the hot tank, the temperature was raised to 75°C for spray drying. The air inlet temperature was 167°C and the outle...

Embodiment 2

[0043] A method for extracting Albizia julibrissin medicinal material:

[0044] Weigh the Albizia Julibrissin medicinal material, remove visible foreign matter and impurities, put the Albizia Julibrissin decoction pieces into a static multi-functional extraction tank, add 95-100°C boiling water 11 times the weight of the Albizia Julienne flower, turn on the bypass heating, and keep the temperature at 95-100°C , soak and extract for 25 minutes, filter; add 9 times the weight of Albizia Julibrissin flower in 95-100°C boiling water again, turn on bypass heating, keep the temperature at 95-100°C, soak and extract for 25 minutes, filter; combine the secondary extraction Liquid, import the extract into a vacuum single-effect concentration tank, open the steam valve and vacuum pump, and carry out vacuum drying, the pressure is -0.07MPa, the concentration temperature is 65°C, the relative density of the concentrate is 1.02 (60°C), and the concentrate is introduced into Put it into the...

Embodiment 3

[0046] A kind of extraction method of salvia miltiorrhiza medicinal material:

[0047] Weigh the medicinal material of salvia miltiorrhiza, and use a pulverizer to pulverize the medicinal material of salvia miltiorrhiza into coarse particles with a particle size below 1 cm. Put the crushed Danshen decoction pieces into a static multi-functional extraction tank, add 95-100°C boiling water 12 times the weight of the Danshen medicinal material, turn on the bypass heating, keep the temperature at 95-100°C, soak and extract for 20 minutes, and filter; Add boiling water at 95-100°C that is 10 times the weight of Danshen medicinal materials, turn on the bypass heating, keep the temperature at 95-100°C, soak and extract for 30 minutes, filter; combine the secondary extracts, and import the extracts into a vacuum single-effect concentration tank , turn on the steam valve and vacuum pump, carry out vacuum drying, the pressure is -0.09MPa, the concentration temperature is 70°C, the relativ...

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Abstract

The invention provides an extraction method applicable to water-soluble thermal-sensitive components of traditional Chinese medicines. The extraction method includes steps: adding water at 95-100 DEGC into medicinal materials, heating to keep the temperature at 95-100 DEG C, and performing soaking extraction for 15-30min for 2-3 times. According to the extraction method, the water at 95-100 DEG Cis adopted for repeated soaking extraction of the traditional Chinese medicinal materials, and by strict control of soaking time and extraction times, loss of the thermal-sensitive components is reduced while complete extraction of effective components is guaranteed. By adoption of the boiled water, microorganisms in water and extract liquid can be eliminated, so that storage time of the extractliquid is prolonged, and the risk of disqualification in bacterium detection of finished products is reduced; in addition, dissolved matters of water-soluble impurities in the medicinal materials arereduced, the effective component content is increased, and dosis is reduced for patients.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical and chemical production, in particular to an extraction method suitable for water-soluble heat-sensitive components of traditional Chinese medicine. Background technique [0002] With the continuous advancement of science and technology, traditional Chinese medicine dosage forms are not limited to traditional soups, pills, powders, ointments, etc. New dosage forms such as traditional Chinese medicine formula granules have been accepted and used by a large number of patients. Traditional Chinese medicine formula granules, also known as decoction-free Chinese herbal pieces, new decoction pieces, refined decoction pieces, etc., refer to extracting the active ingredients in traditional Chinese medicine decoction pieces through the extraction method of traditional Chinese medicine preparations, selecting appropriate solvents and techniques, and then through concentration, drying, Made into granu...

Claims

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Application Information

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IPC IPC(8): B01D11/02A61K36/286A61K36/634A61K36/355A61K36/48A61K36/537
CPCA61K36/286A61K36/355A61K36/48A61K36/537A61K36/634B01D11/02
Inventor 郝磊孙福仁李雪利田方李军山李振江
Owner SHINEWAY PHARMA GRP LTD
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