APTT (activated partial thromboplastin time) detecting agent stabilizer and APTT detecting agent

A detection reagent and stabilizer technology, applied in the field of biological detection, can solve the problems of expensive imported products, unstable test results, unstable product quality, etc., achieve excellent anti-corrosion and antibacterial effects, improve stability and production safety, Reduce the effect of poor long-term storage stability

Active Publication Date: 2019-03-08
NINGBO RUI BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, domestic APTT detection reagents generally have problems such as unstable product quality and easy precipitation of reagents, resulting in unstable test results, and it is difficult to compare the results measured by different clinical testing laboratories.
Therefore, most of the reagents used in clinical laboratories are imported products, but imported products are expensive

Method used

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  • APTT (activated partial thromboplastin time) detecting agent stabilizer and APTT detecting agent
  • APTT (activated partial thromboplastin time) detecting agent stabilizer and APTT detecting agent
  • APTT (activated partial thromboplastin time) detecting agent stabilizer and APTT detecting agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] The stabilizing agent that is used for APTT detection reagent in the present embodiment is made up of the component of following mass percentage:

[0059] Oligochitosan 55.3%,

[0060] Glucosamine 20.8%,

[0061] Ascorbic Acid 3.0%,

[0062] Butylated Hydroxytoluene 1.2%,

[0063] Mannitol 19.7%.

Embodiment 2

[0065] The stabilizing agent that is used for APTT detection reagent in the present embodiment is made up of the component of following mass percentage:

[0066] Oligochitosan 57.14%,

[0067] Glucosamine 19.05%,

[0068] Ascorbic acid 3.81%,

[0069] Butylated Hydroxytoluene 0.95%,

[0070] Mannitol 19.05%.

Embodiment 3

[0072] The stabilizing agent that is used for APTT detection reagent in the present embodiment is made up of the component of following mass percentage:

[0073] Oligochitosan 58.9%,

[0074] Glucosamine 17.2%,

[0075] Ascorbic Acid 4.5%,

[0076] Butylated Hydroxytoluene 0.7%,

[0077] Mannitol 18.7%.

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Abstract

The invention relates to an APTT detecting agent stabilizer and an APTT detecting agent and belongs to the technical field of biological detection. The APTT detecting agent is composed of, by weight percentage, 55.3-58.9% of chitosan oligosaccharide, 17.2-20.8% of glucosamine and auxiliary agents as balance. The dosage of the APTT detecting agent stabilizer in the APTT detecting agent containing gallogen and rabbit cephalin is 5.0-5.5%. The APTT detecting agent stabilizer is green and toxicity-free, safe in production process and good in stabilizing effects on the APTT detecting agent.

Description

technical field [0001] The invention belongs to the technical field of biological detection, and relates to a stabilizer for APTT detection reagents and APTT detection reagents. Background technique [0002] Human coagulation pathways are divided into intrinsic coagulation pathway and extrinsic coagulation pathway, and activated partial thromboplastin time (APTT) is an important indicator of the intrinsic coagulation system. The reasons for APTT prolongation are often caused by the reduction of blood coagulation factors II, V, VIII, IX, XI, and XII, fibrinogen deficiency, enhanced fibrinolytic activity, and the presence of anticoagulant substances (such as increased blood heparin content and oral anticoagulants). APTT shortening is often caused by hypercoagulable states and thrombotic diseases (such as myocardial infarction, unstable angina, cerebrovascular disease, pulmonary infarction, deep vein thrombosis, pregnancy-induced hypertension and nephrotic syndrome). Therefore...

Claims

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Application Information

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IPC IPC(8): G01N33/86
CPCG01N33/86G01N2333/974
Inventor 章思思张闻陈媛周海滨
Owner NINGBO RUI BIO TECH
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