Novel drug capsule processing method

A technology for capsule processing and medicine, applied in the directions of capsule delivery, pharmaceutical formulations, and non-active ingredients medical preparations, etc., can solve the problems of fragile or softened, unsatisfactory elasticity, short storage time, etc. The effect of extended period and reasonable moisture content

Inactive Publication Date: 2019-03-22
哈尔滨瀚钧现代制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in order to facilitate the dissolution and absorption in the stomach, the existing capsules are easily broken or softened. At the same time, the elasticity is not satisfactory, and the storage time is short, which is not conducive to use.

Method used

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  • Novel drug capsule processing method
  • Novel drug capsule processing method

Examples

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Effect test

Embodiment 1

[0029] A novel pharmaceutical capsule processing method, comprising step 1, raw material selection; step 2, preparation of capsule liquid; step 3, manufacture of capsule body; step 4, demoulding of capsule body; step 5, subsequent processing; step 6, inspection of packaging;

[0030] In step one, according to the mass percentage of each component, it is respectively: 20% medicinal gelatin, 10% hypromellose, 15% starch mixture, 10% carrageenan, and 10% pectin , 5% gum tragacanth, 15% gum arabic and 15% alcohol mixture are selected, and weighed according to the sum of the percentages by weight being 1;

[0031] In step two, the preparation of the capsule liquid includes the following steps:

[0032] 1) Slowly add the starch mixture into a heatable container filled with pure water, and keep stirring, the stirring speed is 50-80rpm, the temperature is maintained at 50-60°C, and the weight of the pure water is 4% of the weight of the raw material except the alcohol mixture. -5 ti...

Embodiment 2

[0044] A novel pharmaceutical capsule processing method, comprising step 1, raw material selection; step 2, preparation of capsule liquid; step 3, manufacture of capsule body; step 4, demoulding of capsule body; step 5, subsequent processing; step 6, inspection of packaging;

[0045] In step one, according to the mass percentage of each component, it is respectively: 20% medicinal gelatin, 10% hypromellose, 15% starch mixture, 10% carrageenan, and 10% pectin , 7% gum tragacanth, 13% gum arabic and 15% alcohol mixture are selected, and weighed according to the sum of the percentages by weight being 1;

[0046] In step two, the preparation of the capsule liquid includes the following steps:

[0047] 1) Slowly add the starch mixture into a heatable container filled with pure water, and keep stirring, the stirring speed is 50-80rpm, the temperature is maintained at 50-60°C, and the weight of the pure water is 4% of the weight of the raw material except the alcohol mixture. -5 ti...

Embodiment 3

[0059] A novel pharmaceutical capsule processing method, comprising step 1, raw material selection; step 2, preparation of capsule liquid; step 3, manufacture of capsule body; step 4, demoulding of capsule body; step 5, subsequent processing; step 6, inspection of packaging;

[0060] In step one, according to the mass percentage of each component, it is respectively: 20% medicinal gelatin, 10% hypromellose, 15% starch mixture, 10% carrageenan, and 10% pectin , 8% gum tragacanth, 12% gum arabic and 15% alcohol mixture are selected, and weighed according to the sum of the percentages by weight being 1;

[0061] In step two, the preparation of the capsule liquid includes the following steps:

[0062] 1) Slowly add the starch mixture into a heatable container filled with pure water, and keep stirring, the stirring speed is 50-80rpm, the temperature is maintained at 50-60°C, and the weight of the pure water is 4% of the weight of the raw material except the alcohol mixture. -5 ti...

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Abstract

The invention discloses a novel drug capsule processing method which comprises the following steps: 1, selecting raw materials; 2, preparing a capsule liquid; 3, making capsule bodies; 3, demolding the capsule bodies; 5, performing subsequent treatment; 6, inspecting and packaging. In the step 1, the raw materials comprise the following components in percentage by mass: 20-30% of pharmaceutical gelatin, 8-10% of hydroxypropyl methylcellulose, 10-20% of a starch mixture, 8-10% of carrageenan, 5-10% of pectin, 5-8% of tragacanth, 10-15% of Arabic gum and 10-20% of an alcohol mixture. The materials are weighed according to the sum 1 of the weight percent. According to the novel drug capsule processing method, the processed capsule is smooth in surface, uniform in color, high in stability, reasonable in moisture content and difficult to break or soften; due to the addition of the tragacanth and the Arabic gum, the elasticity of the capsule is greatly increased, the capsule is convenient topreserve, and the storage life is greatly prolonged.

Description

technical field [0001] The invention relates to the technical field of capsule production, in particular to a novel pharmaceutical capsule processing method. Background technique [0002] Drugs packed in capsules are generally powders or granules that are irritating to the esophagus and gastric mucosa, or drugs that taste bad, are easy to volatilize, are easily decomposed by saliva in the mouth, and are easy to inhale into the trachea. These medicines are packed into capsules, which not only protects the properties of the medicine from being destroyed, but also protects the digestive organs and respiratory tract. Removing the capsule shell may result in drug loss, drug waste, and reduced drug efficacy. In addition, some drugs need to be dissolved and absorbed in the intestines, and the capsules protect the drugs from being destroyed by gastric acid. However, the existing capsules are easily broken or softened in order to facilitate dissolution and absorption in the stomach...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K47/38A61K47/36
CPCA61K9/4816A61K9/4825
Inventor 贾德君孙诗蕊
Owner 哈尔滨瀚钧现代制药有限公司
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