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Compound sulfamonomethoxine microcapsule preparation and preparation method thereof

A technology of sulfa-metamethoxine and methoxine, which is applied in the field of compound sulfa-metamethoxine microcapsule preparation and its preparation, can solve the problems of organic solvent consumption, body stimulation, etc., and achieve simple production process, save production cost, long-lasting effect

Active Publication Date: 2019-03-22
FOSHAN STANDARD BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The object of the present invention is to provide a kind of compound sulfamethoxine microcapsule preparation and preparation method thereof, solve the problem that existing method consumes a large amount of organic solvents and easily causes the stimulation of body

Method used

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  • Compound sulfamonomethoxine microcapsule preparation and preparation method thereof
  • Compound sulfamonomethoxine microcapsule preparation and preparation method thereof
  • Compound sulfamonomethoxine microcapsule preparation and preparation method thereof

Examples

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Effect test

Embodiment 1

[0021] A compound sulfamonomethoxine microcapsule preparation, in parts by mass, prepared from the following raw materials: 10.0 parts by weight of sulfamethoxine, 2.1 parts by weight of trimethoprim, 61.9 parts by weight of sustained-release agent, and organic The solvent is 6.0 parts by weight and the filler is 20.0 parts by weight.

[0022] The sustained-release agent is monoglyceride, the organic solvent is PEG4000, and the filler is a mixture of starch and light calcium carbonate. The mixing mass ratio of the two is 1:1.

[0023] The preparation steps are:

[0024] 1) Set the water heating temperature of the emulsification tank to 95°C, put 61.9 parts by weight of monoglyceride and 6.0 parts by weight of PEG4000 into the emulsification tank, and when the temperature of the material rises to about 80°C, start stirring to make the material completely melted.

[0025] 2) After the materials are completely melted, adjust the emulsification tank water heating temperature to 82°C, turn...

Embodiment 2

[0029] A compound sulfamonomethoxine microcapsule preparation, based on parts by mass, prepared from the following raw materials: 5.0 parts by weight of sulfamethoxine, 4.0 parts by weight of trimethoprim, 55.0 parts by weight of sustained-release agent, and organic 10.0 parts by weight of solvent and 26.0 parts by weight of filler.

[0030] The sustained-release agent is monoglyceride, the organic solvent is PEG4000, and the filler is a mixture of starch and light calcium carbonate. The mixing mass ratio of the two is 1:1.

[0031] The preparation steps are:

[0032] 1) Set the water heating temperature of the emulsification tank to 95°C, put 55.0 parts by weight of monoglyceride and 10.0 parts by weight of PEG4000 into the emulsification tank, and when the temperature of the material rises to about 80°C, start stirring to make the material completely melted.

[0033] 2) After the materials are completely melted, adjust the emulsification tank water heating temperature to 82°C, turn ...

Embodiment 3

[0037] A compound sulfamonomethoxine microcapsule preparation, based on parts by mass, prepared from the following raw materials: 20.0 parts by weight of sulfamethoxine, 1.0 part by weight of trimethoprim, 65.0 parts by weight of sustained-release agent, and organic The solvent is 4.0 parts by weight, and the filler is 10.0 parts by weight.

[0038] The sustained-release agent is monoglyceride, the organic solvent is PEG4000, and the filler is a mixture of starch and light calcium carbonate. The mixing mass ratio of the two is 1:1.

[0039] The preparation steps are:

[0040] 1) Set the water heating temperature of the emulsification tank to 95°C, put 65.0 parts by weight of monoglyceride and 4.0 parts by weight of PEG4000 into the emulsification tank, and when the temperature of the material rises to about 80°C, start stirring to make the material completely melted.

[0041] 2) After the materials are completely melted, adjust the emulsification tank water heating temperature to 82°C...

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Abstract

The invention discloses a compound sulfamonomethoxine microcapsule preparation. The compound sulfamonomethoxine microcapsule preparation is characterized by being prepared from the following raw materials in parts by mass: 5 to 20 parts of sulfamonomethoxine, 1 to 4 parts of trimethoprim, 55 to 65 parts of a slow release formulation, 4 to 10 parts of an organic solvent and 10 to 30 parts of a filler. A sulfamonomethoxine premix prepared by the invention has the advantages that most gram-positive bacteria and certain negative bacteria can be inhibited; good preventing and controlling effects onsystemic infection caused by toxoplasmosis, escherichia coli, pasteurella, streptococcus, haemophilus parasuis, eperythrozoon, actinobacillus and the like are achieved; the long-term effect is obvious, and antibacterial activity and curative effects are greatly enhanced; a production process is simple, so that the production cost is reduced; the compound sulfamonomethoxine microcapsule preparation is suitable for industrial production.

Description

Technical field [0001] The invention relates to a compound sulfamonomethoxine microcapsule preparation and a preparation method thereof. Background technique [0002] Sulfamonomethoxine (SMM) is a sulfa drug with a wide range of applications. It has the advantages of broad antibacterial spectrum, stable properties, low price and a variety of preparations to choose from. It can interfere with the synthesis of bacterial folic acid and affect its growth and reproduction, thereby inhibiting most Gram-positive bacteria and certain negative bacteria, preventing and controlling Toxoplasma, Escherichia coli, Pasteurella, Streptococcus, Haemophilus parasuis Systemic infections caused by erythropoiesis, actinobacteria, etc. have a good effect. With dual pharmacological effects, it can be antibacterial and antiprotozoal, and it is sensitive to pig coccidia and Toxoplasma. Although antibiotics have developed rapidly in recent years, sulfa drugs have not been eliminated, and they still occu...

Claims

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Application Information

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IPC IPC(8): A61K31/635A61K9/50A61P31/04A61K31/505
CPCA61K9/1652A61K31/505A61K31/635A61P31/04A61K2300/00Y02A50/30
Inventor 钱嘉伟刘肖娟王俊谭志坚陈艺青黎剑坤符德文
Owner FOSHAN STANDARD BIO TECH
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