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A kind of compound sulfamethoxine microcapsule preparation and preparation method thereof

A technology of sulfamonomethoxine and methoxypyrim, which is applied in the field of compound sulfamonomethoxine microcapsule preparation and preparation thereof, can solve the problems of consumption of organic solvent, body stimulation and the like, and achieves simple production process, saving production cost, long-lasting effect

Active Publication Date: 2021-04-20
FOSHAN STANDARD BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The object of the present invention is to provide a kind of compound sulfamethoxine microcapsule preparation and preparation method thereof, solve the problem that existing method consumes a large amount of organic solvents and easily causes the stimulation of body

Method used

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  • A kind of compound sulfamethoxine microcapsule preparation and preparation method thereof
  • A kind of compound sulfamethoxine microcapsule preparation and preparation method thereof
  • A kind of compound sulfamethoxine microcapsule preparation and preparation method thereof

Examples

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Effect test

Embodiment 1

[0021] A compound sulfamethoxine microcapsule preparation prepared in parts by mass from the following raw materials: 10.0 parts by weight of sulfamethoxine, 2.1 parts by weight of trimethoprim, 61.9 parts by weight of a sustained-release agent, organic 6.0 parts by weight of solvent, and 20.0 parts by weight of filler.

[0022] The sustained-release agent is monoglyceride, the organic solvent is PEG4000, the filler is a mixture of starch and light calcium carbonate, and the mixing mass ratio of the two is 1:1.

[0023] Its preparation steps are:

[0024] 1) Set the water heating temperature of the emulsification tank to 95°C, put 61.9 parts by weight of monoglyceride and 6.0 parts by weight of PEG4000 into the emulsification tank, and when the temperature of the materials rises to about 80°C, start stirring to completely melt the materials.

[0025] 2) After the materials are completely melted, adjust the heating temperature of the water in the emulsification tank to 82°C, s...

Embodiment 2

[0029] A compound sulfamethoxine microcapsule preparation prepared in parts by mass from the following raw materials: 5.0 parts by weight of sulfamethoxine, 4.0 parts by weight of trimethoprim, 55.0 parts by weight of a sustained-release agent, organic 10.0 parts by weight of solvent, and 26.0 parts by weight of filler.

[0030] The sustained-release agent is monoglyceride, the organic solvent is PEG4000, the filler is a mixture of starch and light calcium carbonate, and the mixing mass ratio of the two is 1:1.

[0031] Its preparation steps are:

[0032] 1) Set the water heating temperature of the emulsification tank to 95°C, put 55.0 parts by weight of monoglyceride and 10.0 parts by weight of PEG4000 into the emulsification tank, and when the temperature of the materials rises to about 80°C, start stirring to completely melt the materials.

[0033] 2) After the materials are completely melted, adjust the heating temperature of the water in the emulsification tank to 82°C, ...

Embodiment 3

[0037] A compound sulfamethoxine microcapsule preparation prepared in parts by mass from the following raw materials: 20.0 parts by weight of sulfamethoxine, 1.0 parts by weight of trimethoprim, 65.0 parts by weight of a sustained-release agent, organic 4.0 parts by weight of solvent, and 10.0 parts by weight of filler.

[0038] The sustained-release agent is monoglyceride, the organic solvent is PEG4000, the filler is a mixture of starch and light calcium carbonate, and the mixing mass ratio of the two is 1:1.

[0039] Its preparation steps are:

[0040] 1) Set the heating temperature of the water in the emulsification tank to 95°C, put 65.0 parts by weight of monoglyceride and 4.0 parts by weight of PEG4000 into the emulsification tank, and when the temperature of the materials rises to about 80°C, start stirring to completely melt the materials.

[0041] 2) After the materials are completely melted, adjust the water heating temperature of the emulsification tank to 82°C, s...

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Abstract

The invention discloses a compound sulfamethoxine microcapsule preparation, which is characterized in that, in parts by mass, the preparation raw materials contain: 5-20 parts of sulfamethoxine and 1-4 parts of trimethoprim , 55-65 parts of slow-release agent, 4-10 parts of organic solvent, 10-30 parts of filler. The compound sulfamethoxine premix prepared by the present invention can inhibit most Gram-positive bacteria and some negative bacteria, prevent and control Toxoplasma gondii, Escherichia coli, Pasteurella, Streptococcus, Haemophilus parasuis , Eperythrozoon, Actinobacillus, etc. cause systemic infection has good effect; the long-term effect is obvious, the antibacterial activity and curative effect are greatly enhanced, the production process is simple, the production cost is saved, and it is suitable for industrial production.

Description

technical field [0001] The invention relates to a compound sulfamethoxine microcapsule preparation and a preparation method thereof. Background technique [0002] Sulfamonomethoxine (SMM) is a widely used sulfa drug, which has the advantages of broad antibacterial spectrum, stable properties, low price and a variety of preparations to choose from. It can interfere with the synthesis of bacterial folic acid and affect its growth and reproduction, thereby inhibiting most Gram-positive bacteria and some negative bacteria, preventing and controlling Toxoplasma gondii, Escherichia coli, Pasteurella, Streptococcus, Haemophilus parasuis , Eperythrozoon, Actinobacillus and other systemic infections caused by a good effect. With dual pharmacological effects, it can not only be antibacterial, but also antiprotozoal, and is sensitive to coccidia and toxoplasma. Although antibiotics have developed rapidly in recent years, sulfonamides have not been eliminated, and still occupy an impo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/635A61K9/50A61P31/04A61K31/505
CPCA61K9/1652A61K31/505A61K31/635A61P31/04A61K2300/00Y02A50/30
Inventor 钱嘉伟刘肖娟王俊谭志坚陈艺青黎剑坤符德文
Owner FOSHAN STANDARD BIO TECH
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