Compound licorice tablet and preparation method thereof

Abstract

The invention discloses a compound licorice tablet and a preparation method thereof. According to the prescription amount, the formula of the compound licorice tablet per tablet comprises 112.5 mg ofa licorice extract powder, 4 mg of a poppy fruit extract powder, 2 mg of star anise oil, 2 mg of camphor, 2 mg of sodium benzoate, 2-50 mg of a cyclodextrin derivative having an average particle diameter of 1-50 microns, 2-50 mg of magnesium oxide, 0-100 mg of calcium hydrogen phosphate, 0-100 mg of starch, 0-20 mg of microsilica gel and 0-50 mg of a talcum powder. According to the prescription amount, the tablet core of the compound licorice tablet per tablet is 126.5-400 mg. Through an inclusion technology of the cyclodextrin derivative, the volatile matter molecules such as the camphor andthe star anise oil in the compound licorice tablet are included in an inclusion compound molecule, thereby increasing the adsorption and fixation functions for the volatile matters so that the mattersare not volatile and the content of the volatiles is greatly increased.

Description

technical field [0001] The invention relates to the field of medicine manufacturing, in particular to a compound licorice tablet and a preparation method thereof. Background technique [0002] Compound Licorice Tablets is a special pharmaceutical preparation unique to my country. It contains licorice extract powder, poppy fruit extract powder, camphor, star anise oil and other traditional Chinese medicine ingredients. , definite curative effect, high quality and low price, has been used in our country for more than 60 years, and is welcomed by both doctors and patients. [0003] Since the camphor and star anise oil in Compound Licorice Tablets are volatile, they may volatilize during production, storage, and use, resulting in a decrease in the content and affecting the curative effect. [0004] The existing process is to add volatile matter before or after granulating the raw and auxiliary materials, mix with necessary additional auxiliary materials, and then compress the ta...

AI Technical Summary

Problems solved by technology

[0009] (1) Using solvent method (such as patent CN1562307A): when removing solvent (such as precipitation, drying operation), it will cause a large amount of loss of volatile matter, so the content of volatile matter is not high, and the process is complicated and difficult to industrialize;

[0010] (2) Solvent-free method (such as patent CN1433810A): use dry grinding to allow volatiles and cyclodextrin derivatives to interact to produce clathrates. This step is still difficult in industrialization. When equipment and utensils (typically such as ball mills), the surface of the equipment is in contact with the material and produces strong friction, resulting in the adhesion of the material to the surface of the equipment, it is difficult to separate these equipment from the clathrate obtained, resulting in a large loss. The yield is low, and the operation is also very complicated, so it is also a process route that is actually difficult to industrialize

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