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A kind of Qinghuo Zhimai flakes and preparation method thereof

A technology of clearing fire gardenia oatmeal and enzymolysis, which is applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, pharmaceutical combinations, etc., can solve the problems of low active ingredient content, rough preparation process, inconvenient taking and the like, and achieves dissolution time. Shortening, reducing adverse effects, improving safety and stability

Active Publication Date: 2021-08-24
SICHUAN XUYANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Aiming at the above-mentioned deficiencies in the prior art, the present invention provides Qinghuo Zhimai Tablet and its preparation method, which can effectively solve the problem that the existing preparation process is rough and the active ingredient content is low, resulting in excessive dosage for patients and inconvenient taking.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] A kind of Qinghuo Zhimai, its preparation method comprises the following steps:

[0036] (1) Pulverization: pulverize the whole herb of Andrographis paniculata to 20-40 mesh sieves to obtain powder;

[0037] (2) Primary enzymolysis: Add the powder into the cellulase solution for enzymolysis, the enzymolysis temperature is 40°C, and the enzymolysis time is 3 hours to obtain the first enzymolysis solution; wherein, the amount of cellulase added is 500U / g powder;

[0038] (3) Second enzymolysis: filter the first enzymolysis solution, remove the filtrate, dry the filter residue at 40°C, pulverize, then add pectinase solution for enzymolysis, the enzymolysis temperature is 45°C, and the enzymolysis time is 2h, to obtain the second enzymolysis solution; wherein, the amount of pectinase added is 300U / g powder;

[0039] (4) Three times of enzymolysis: filter the second enzymolysis solution, remove the filtrate, dry the filter residue at 45° C., pulverize it, and then add the...

Embodiment 2

[0050] A kind of Qinghuo Zhimai, its preparation method comprises the following steps:

[0051] (1) Pulverization: pulverize the whole herb of Andrographis paniculata to 20-40 mesh sieves to obtain powder;

[0052] (2) Primary enzymolysis: Add the powder into the cellulase solution for enzymolysis, the enzymolysis temperature is 45°C, and the enzymolysis time is 2 hours to obtain the first enzymolysis solution; wherein, the amount of cellulase added is 800U / g powder;

[0053] (3) Second enzymolysis: filter the first enzymolysis solution, remove the filtrate, dry the filter residue at 45°C, pulverize it, then add it to the pectinase solution for enzymolysis, the enzymolysis temperature is 50°C, and the enzymolysis time is 1h, to obtain the second enzymolysis solution; wherein, the amount of pectinase added is 600U / g powder;

[0054] (4) Three times of enzymolysis: filter the second enzymolysis solution, remove the filtrate, dry the filter residue at 45° C., pulverize it, and...

Embodiment 3

[0065] A kind of Qinghuo Zhimai, its preparation method comprises the following steps:

[0066] (1) Pulverization: pulverize the whole herb of Andrographis paniculata to 20-40 mesh sieves to obtain powder;

[0067] (2) Primary enzymolysis: Add the powder into the cellulase solution for enzymolysis, the enzymolysis temperature is 40°C, and the enzymolysis time is 3 hours to obtain the first enzymolysis solution; wherein, the amount of cellulase added is 600U / g powder;

[0068] (3) Second enzymolysis: filter the first enzymolysis solution, remove the filtrate, dry the filter residue at 45°C, pulverize it, then add it to the pectinase solution for enzymolysis, the enzymolysis temperature is 50°C, and the enzymolysis time is 2h, to obtain the second enzymolysis solution; wherein, the addition amount of pectinase is 500U / g powder;

[0069] (4) Three times of enzymolysis: filter the second enzymolysis solution, remove the filtrate, dry the filter residue at 45° C., pulverize it, ...

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PUM

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Abstract

The invention discloses Qinghuozhimai tablets and a preparation method thereof. The preparation method comprises the following steps: crushing, primary enzymolysis, secondary enzymolysis, three enzymolysis, extraction, decolorization, concentration, crystallization, supercritical extraction, microwave Extraction, concentration, decoction, granulation, tableting, coating. Each step in the preparation method of the invention is interlocking, so that the content and purity of the active ingredients in the Qinghuo Zhimai Tablet can be effectively improved, and when used, a very small dose can be used to achieve a good curative effect, which is convenient for patients to take.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to Qinghuozhimai tablets and a preparation method thereof. Background technique [0002] Qinghuo Zhimai is a commonly used variety of traditional Chinese medicine for clearing fire. Its prescriptions are Andrographis paniculata, Gardenia and Ophiopogon japonicus. It has the effects of clearing away heat and detoxifying, cooling blood and reducing swelling. , toothache, red eyes. The preparation process in the prior art is rough and the active ingredient content is low, which leads to excessive dosage for patients and is inconvenient to take, which seriously affects its clinical application. Contents of the invention [0003] Aiming at the above-mentioned deficiencies in the prior art, the present invention provides Qinghuo Zhimai Tablet and its preparation method, which can effectively solve the problems of rough preparation process and low content...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/28A61K36/8968A61P29/00A61P11/04A61P1/02A61P27/02
CPCA61K9/28A61K36/19A61K36/744A61K36/8968A61K2236/19A61K2236/331A61K2236/333A61K2236/37A61K2236/39A61K2236/51A61K2236/53A61P1/02A61P11/04A61P27/02A61P29/00A61K2300/00
Inventor 韩业详杨文生
Owner SICHUAN XUYANG PHARMA