Elastic double-layer tubular tissue engineering scaffold with multistage porous structure and preparation method thereof

A technology of tissue engineering scaffolds and pore structures, which can be applied in tissue regeneration, pharmaceutical formulations, additive processing, etc. It can solve the problems that FDM is difficult to directly print porous tubular scaffolds, and achieve good application prospects and simple methods.
CN109529122AInactive Publication Date: 2019-03-29DONGHUA UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
DONGHUA UNIV
Publication Date
2019-03-29
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to an elastic double-layer tubular tissue engineering scaffold with a multistage porous structure and a preparation method thereof. The tissue engineering scaffold includes nanofibers and a tubular spring scaffold which is prepared through 4-axis 3D printing. The nano fibers coat the surface of the scaffold to form the double-layer structure. The multistage porous structureincludes the pores formed by interlacing the linear materials in the tubular spring scaffold, micro-pores or nano-pores, which are uniformly distributed in the linear materials and are communicated with each other, and nano-porous structures, which are formed by depositing, wrapping and interlacing the nano fibers. The invention solves the essential problem that FDM is difficult to directly use for printing a porous tubular scaffold. The tissue engineering scaffold has the accurately-controllable multistage porous structure. The method is simple and quick, is suitable for various biomaterialsand has excellent application prospect.
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Description

technical field

[0001] The invention belongs to the field of tissue engineering scaffolds, in particular to an elastic double-layer tubular tissue engineering scaffold with a multi-level pore structure and a preparation method thereof. Background technique

[0002] As an interdisciplinary field, tissue engineering comprehensively applies the basic principles of engineering and life sciences, and involves the cross-integration of a series of disciplines such as clinical medicine, biomaterials, cell biology, and bioengineering. A physiologically functional substitute that repairs, maintains, or improves human diseased tissue. There are a large number of tubular structures or organs in the human body, such as blood vessels, trachea, esophagus, intestines, urethra, etc., all of which play an important role in maintaining normal physiological activities of the human body. The lesions of these tubular tissues will cause great harm to the human body even death. Globally, cardiova...

Claims

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