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Elastic double-layer tubular tissue engineering scaffold with multistage porous structure and preparation method thereof

A technology of tissue engineering scaffolds and pore structures, which can be applied in tissue regeneration, pharmaceutical formulations, additive processing, etc. It can solve the problems that FDM is difficult to directly print porous tubular scaffolds, and achieve good application prospects and simple methods.

Inactive Publication Date: 2019-03-29
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem to be solved by the present invention is to provide an elastic double-layer tubular tissue engineering scaffold with a multi-level pore structure and its preparation method, which solves the fundamental problem that FDM is difficult to directly print porous tubular scaffolds

Method used

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  • Elastic double-layer tubular tissue engineering scaffold with multistage porous structure and preparation method thereof
  • Elastic double-layer tubular tissue engineering scaffold with multistage porous structure and preparation method thereof
  • Elastic double-layer tubular tissue engineering scaffold with multistage porous structure and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0041] 1. Preparation process

[0042] 1.1 Printing material preparation

[0043] The mixing parameters of PGS prepolymer (Pre-PGS) and salt particles directly determine the extrudability, initial shape stability, high-temperature curing shape retention and pore structure of the scaffold during printing, which indirectly determine the performance of the scaffold. Including mechanical properties and biodegradability. Dissolve 10g Pre-PGS in 10ml acetone to form a viscous solution; put NaCl in a pulverizer and grind it, and pass through a sieve to get salt particles with a diameter less than 38μm; add salt particles and Pre-PGS at a mass ratio of 1:2 Mix 20g evenly, let the acetone volatilize slightly, then put it in a vacuum oven at 30°C for 24 hours to remove the acetone;

[0044] 1.2 4-axis 3D printing of Pre-PGS fiber interwoven tubular structure

[0045] A mixture of Pre-PGS and NaCl particles was loaded into the cartridge. Set extrusion chamber temperature and nozzle t...

Embodiment 2

[0063] 1. Preparation process

[0064] 1.1 4-axis printing of tubular structures interwoven with PCL fibers

[0065] The thermoplastic PCL polymer pellets were charged into the barrel. Set the extrusion chamber temperature and nozzle temperature to 180°C. Choose a 23G needle and print a length of 6 cm. Set the XY axis movement speed V m 1mm / s, T-axis extrusion speed V e is 0.0005mm / s. Choose a different diameter D r The PTFE round rod (2mm, 4mm, 10mm) is installed on the rotatable receiving platform as the receiver. Adjust the distance between the nozzle and the receiver to be 3mm, and the rotation speed to be 20r / min. The composite material is extruded in a line shape and deposited on the surface of the round rod. With the movement of the nozzle, a spiral structure is printed on the surface of the round rod. After reciprocating printing for 5 times (or multiple times), a fiber-interwoven tubular structure with different diameters is formed. Figure 8 .

[0066] 1.2 P...

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Abstract

The invention relates to an elastic double-layer tubular tissue engineering scaffold with a multistage porous structure and a preparation method thereof. The tissue engineering scaffold includes nanofibers and a tubular spring scaffold which is prepared through 4-axis 3D printing. The nano fibers coat the surface of the scaffold to form the double-layer structure. The multistage porous structureincludes the pores formed by interlacing the linear materials in the tubular spring scaffold, micro-pores or nano-pores, which are uniformly distributed in the linear materials and are communicated with each other, and nano-porous structures, which are formed by depositing, wrapping and interlacing the nano fibers. The invention solves the essential problem that FDM is difficult to directly use for printing a porous tubular scaffold. The tissue engineering scaffold has the accurately-controllable multistage porous structure. The method is simple and quick, is suitable for various biomaterialsand has excellent application prospect.

Description

technical field [0001] The invention belongs to the field of tissue engineering scaffolds, in particular to an elastic double-layer tubular tissue engineering scaffold with a multi-level pore structure and a preparation method thereof. Background technique [0002] As an interdisciplinary field, tissue engineering comprehensively applies the basic principles of engineering and life sciences, and involves the cross-integration of a series of disciplines such as clinical medicine, biomaterials, cell biology, and bioengineering. A physiologically functional substitute that repairs, maintains, or improves human diseased tissue. There are a large number of tubular structures or organs in the human body, such as blood vessels, trachea, esophagus, intestines, urethra, etc., all of which play an important role in maintaining normal physiological activities of the human body. The lesions of these tubular tissues will cause great harm to the human body even death. Globally, cardiova...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/40A61L27/56A61L27/18A61L27/22A61L27/24A61L27/50B33Y10/00B33Y70/00
CPCA61L27/18A61L27/222A61L27/24A61L27/507A61L27/56A61L2400/12A61L2430/22B33Y10/00B33Y70/00C08L67/04C08L67/00
Inventor 游正伟雷东
Owner DONGHUA UNIV
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