An epigenome-based drug discovery method and its application

Abstract

The invention relates to an epigenome-based drug discovery method and application thereof, belonging to the technical field of biomedicine. Starting from the basic principle of drug action, the present invention combines the DNA methylation chip data of patient samples and the interaction network between genes, and uses the revised PageRank algorithm to mine the key pathogenic genes in the process of disease pathogenesis, so that according to the corresponding relationship of drug targets , to search for potential drugs to treat diseases. This method has the characteristics of solid theoretical foundation, easy implementation and high efficiency, and has broad application prospects in drug discovery.

Description

technical field

[0001] The invention relates to an epigenome-based drug discovery method and application thereof, belonging to the technical field of biomedicine. Background technique

[0002] Drug research and development is a process with long cycle, high cost, high risk, fierce competition and high profit. According to statistics, it takes 10-15 years for a new drug to be produced from conception, laboratory lead compound identification, optimization, clinical trials to final marketing, and the research and development costs are as high as more than 800 million US dollars (DiMasi, J.A., Hansen, R.W., and Grabowski, H.G. (2003). The price of innovation: new estimates of drug development costs. J. Health Econ. 22:151-185.), and this cost is still increasing year by year. However, such a huge investment has not received a corresponding return. In 1996, there were 53 FDA-approved drugs, but in 2007 it dropped to 15, a record low (Hughes, B. (2008). 2007 FDA drug approvals: ...

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