Hyaluronic acid stock solution and preparation method thereof

A technology of hyaluronic acid and mixed solution, which is applied in the fields of pharmaceutical formulations, cosmetic preparations, dressing preparations, etc. It can solve the problems of inability to increase hyaluronic acid hyaluronic acid, etc., achieve strong and long-lasting moisturizing ability, improve regeneration rate, The effect of promoting

Inactive Publication Date: 2019-04-16
深圳市琉璃光生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] However, the conventional sodium hyaluronate currently on the market has a molecular weight of tens of thousands or even millions. This large molecular weight moisturizing s

Method used

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  • Hyaluronic acid stock solution and preparation method thereof

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preparation example Construction

[0037] A preparation method of hyaluronic acid stock solution, comprising:

[0038] Preparation steps of mixed solution A: mix butanediol and p-hydroxyacetophenone in the prescribed amount, heat to 85-90°C, and obtain mixed solution A after dissolving;

[0039] The preparation steps of the mixed solution B: adding the sodium hyaluronate, hydrolyzed chitin and hydroxyethyl cellulose in the formula amount into glycerin, and dispersing evenly to obtain the mixed solution B;

[0040]Preparation steps of mixed liquid C: add the water in the formula amount into the emulsification pot, heat to 85-90°C, then add the mixed liquid A and mixed liquid B, and the formula amount of betaine, and homogenize at a speed of 2000-2500rmp 3 -5min, and then stirred at a speed of 60-70rmp for 20min to obtain a mixed solution C;

[0041] Production steps: Cool down the mixture C to 40°C, add the formula amount of oat-β-glucan, the mixture of sclerotin and phenoxyethanol, 1,2-hexanediol, and stir at ...

Embodiment 1-3

[0048] A hyaluronic acid stock solution, comprising the following components by weight percentage: butylene glycol, glycerin, sodium hyaluronate, hydroxyethyl cellulose, betaine, hydrolyzed chitin, p-hydroxyacetophenone, oat-β-glucan A mixture of sugar, sclerotin and phenoxyethanol, 1,2-hexanediol and purified water (see Table 1 for the specific formula), prepared according to the following method:

[0049] Preparation steps of mixed solution A: mix butanediol and p-hydroxyacetophenone in the prescribed amount, heat to 85°C, and obtain mixed solution A after dissolving;

[0050] Preparation steps of mixed solution B: adding sodium hyaluronate, hydrolyzed chitin and hydroxyethyl cellulose in the prescribed amount into glycerin, and dispersing evenly to obtain mixed solution B;

[0051] Preparation steps of mixed liquid C: Add the water in the formula amount into the emulsification pot, heat to 85°C, then add the mixed liquid A and mixed liquid B, and the formula amount of betai...

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Abstract

The invention discloses a hyaluronic acid stock solution, which comprises, by weight, 4-10% of butanediol, 2-7% of glycerol, 0.05-0.5% of sodium hyaluronate, 0.2-0.8% of hydroxyethyl cellulose, 0.5-2%of betaine, 1-5% of hydrolyzed chitin, 0.3-1.2% of p-hydroxyacetophenone, 0.5-2% of oat-beta-glucan, 0.1-0.8% of a mixture of sclerotium and phenoxyethanol,0.2-1% of 1, 2-hexanediol, water and the balance; the sum of the weight percentages of the above components is 100%. According to the hyaluronic acid stock solution, a hyaluronic acid precursor with small molecular weight is permeated into skin, so that the synthesis speed of the hyaluronic acid in the skin is promoted; and moreover, the hyaluronic acid stock solution is fresh and non-greasy in texture, and is water-supplementing and moisture-preserving. The invention also discloses a preparation method of the hyaluronic acid stock solution, which has simple operation and lower cost and is suitable for most production equipment on themarket.

Description

technical field [0001] The invention relates to the technical field of cosmetics, in particular to a hyaluronic acid stock solution and a preparation method thereof. Background technique [0002] Hyaluronic acid (commonly known as hyaluronic acid) is a long-lasting moisturizing ingredient, which is very popular among beauty lovers. In fact, a small amount of sodium salt of hyaluronic acid is generally added as a moisturizing ingredient in conventional skin care products. But in fact, human skin contains hyaluronic acid as an ingredient, but as we age, the synthesis rate of hyaluronic acid in the human body slows down and the decomposition rate increases. At this time, people need to use some external supplements to delay various skin problems. [0003] However, the conventional sodium hyaluronate currently on the market has a molecular weight of tens of thousands or even millions. This large molecular weight moisturizing substance can only stay on the surface of the skin to...

Claims

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Application Information

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IPC IPC(8): A61K8/73A61K8/34A61K8/44A61Q19/00
CPCA61K8/345A61K8/34A61K8/44A61K8/73A61K8/731A61K8/735A61K8/736A61K2800/592A61K2800/5922A61Q19/00
Inventor 甄春桦曾芳芳王艳刘磊王泽智
Owner 深圳市琉璃光生物科技有限公司
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