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Test method of benzalkonium chloride content in wet wipes

A technology of benzalkonium chloride and a test method, applied in the field of chemical detection, can solve problems such as skin damage, inability to sterilize other items, etc., and achieve the effects of small operator error, wide application range, and credible and reliable results

Inactive Publication Date: 2019-04-16
YANGZHOU PERFECT DAILY CHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The wet wipes on the market can be roughly divided into two categories: one is to be sterilized itself, but cannot sterilize other items, and contains skin care ingredients, which can only be used for skin moisturizing and maintenance
The other type is disinfectant wipes that are not only disinfected themselves, but can also disinfect other items. They can be used to disinfect or sterilize skin abrasions and scratches. Generally, disinfection or sterilization will be indicated on the packaging ingredients, but the usual antibacterial agents have certain damage to the skin, if used in excess, it will cause serious damage to the skin

Method used

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  • Test method of benzalkonium chloride content in wet wipes
  • Test method of benzalkonium chloride content in wet wipes
  • Test method of benzalkonium chloride content in wet wipes

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Experimental program
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specific Embodiment

[0057] 1. System suitability test

[0058] 1. Configuration of standard solution:

[0059] 1.1 Prepare a stock solution of benzalkonium chloride standard solution with a concentration of 3 mg / ml.

[0060] 1.2 Pipette 4.0ml of benzalkonium chloride standard solution stock solution, dilute to 10ml with purified water, and prepare a standard solution of about 1.2mg / ml.

[0061] 2. Chromatographic conditions:

[0062] Instrument: Waters E2695with 2998PDA

[0063] Chromatographic column: Waters CN 4.6×250mm, 5μm

[0064] Mobile phase: acetonitrile: 0.1N sodium acetate solution (adjust the pH value to 5.0 with acetic acid) = 45:55

[0065] Detection wavelength: 262nm

[0066] Flow rate: 2ml / min

[0067] Injection volume: 20μL

[0068] Chromatographic column temperature: 35°C

[0069] 3. System suitability:

[0070] Take the blank solution (purified water) and inject 2 needles. Take the standard solution, inject 6 needles, calculate the separation degree of C12 and C14, and...

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Abstract

The invention belongs to the chemical detection technology field and especially relates to the test method of a benzalkonium chloride content in wet wipes. The method comprises the following steps ofpreparing a standard solution; preparing a sample solution; and injecting the standard solution and the sample solution into a high performance liquid chromatograph to determine a chromatogram, detecting the suitability of the standard solution and calculating the benzalkonium chloride content of the sample solution. The method has the advantages that the high performance liquid chromatography isused for detect, a multi-component USP standard product is adopted, and an external standard method is used to calculate so that a result is trusted and reliable, which is good for controlling productquality; and operation is simple, personnel operation errors are less, detection cost is saved, the method can be used for the detection of a sample with low concentration, and a suitable range is wide.

Description

technical field [0001] The invention belongs to the technical field of chemical detection and relates to the detection of active ingredients in wet wipes and their feed liquids, in particular to a method for testing the content of benzalkonium chloride in wet wipes. Background technique [0002] As a new sanitary product in recent years, wet wipes have a wide range of uses and can be used in various occasions for personal consumption and commercial use, such as civil aviation, family, hotel, restaurant, travel, etc., and are gradually favored by people due to their convenience. With the development of people's hygiene habits and the improvement of the quality of life, wet wipes will gradually become a necessity in people's daily life. Wet wipes are a kind of paper towels made of pure water, non-woven fabrics and other ingredients for wiping your face, hands, or skin. [0003] Wet wipes on the market can be roughly divided into two categories: one is sterilized itself, but c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/06
CPCG01N30/02G01N30/06
Inventor 陈华
Owner YANGZHOU PERFECT DAILY CHEM